(4aR,6R)-6-Hydroxy-1,4a-dimethyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4aR,6R)-6-Hydroxy-1,4a-dimethyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one
• 英文别名: (4aR,6R)-6-hydroxy-1,4a-dimethyl-3,4,5,6,7,8-hexahydronaphthalen-2-one
• 化学式: C₁₂H₁₈O₂
• 分子量: 194.274
• InChiKey: VMCISHXOCUKLMZ-BXKDBHETSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4aR,6R)-6-Hydroxy-1,4a-dimethyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one 、 甲氧基-三氟甲基苯 生成 [(2R,8aR)-5,8a-dimethyl-6-oxo-1,2,3,4,7,8-hexahydronaphthalen-2-yl] (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
  参考文献：
  名称：

  SHIMIZU, NOBUKO;OHKURA, TAMIKO;AKITA, HIROYUKI;OISHI, TAKESHI;IITAKA, YOI+, CHEM. AND PHARM. BULL., 37,(1989) N, C. 1023-1027

  摘要：

  DOI：
• 作为产物：
  描述：

  5,8a-Dimethyl-1,3,4,7,8,8a-hexahydronaphthalene-2,6-dione 、 二异丁基氢化铝 生成 (4aR,6R)-6-Hydroxy-1,4a-dimethyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one
  参考文献：
  名称：

  SHIMIZU, NOBUKO;OHKURA, TAMIKO;AKITA, HIROYUKI;OISHI, TAKESHI;IITAKA, YOI+, CHEM. AND PHARM. BULL., 37,(1989) N, C. 1023-1027

  摘要：

  DOI：

文献信息

• Microbial hydroxylation and functionalization of synthetic polycyclic enones
  作者：Abderrahmane Hammoumi、Jean-Pierre Girault、Robert Azerad、Gilbert Revial、Jean d'Angelo

  DOI：10.1016/s0957-4166(00)80241-4

  日期：1993.6

  The regio- and stereoselective hydroxylation of variously substituted asymmetric 4a-methyl octalenones by selected fungal strains has been shown to afford, sometimes in high yields, several optically pure derivatives, generally hydroxylated in the B-ring. The potential of this method for the preparation of functionalized (hydroxylated) chiral synthons is evaluated and discussed.
• Total Synthesis of (−)-Artemisin
  作者：Masao Nakazaki、Koichiro Naemura

  DOI：10.1246/bcsj.42.3366

  日期：1969.11
• Shimizu, Nobuko; Ohkura, Tamiko; Akita, Hiroyuki, Chemical and pharmaceutical bulletin, 1989, vol. 37, # 4, p. 1023 - 1027
  作者：Shimizu, Nobuko、Ohkura, Tamiko、Akita, Hiroyuki、Oishi, Takeshi、Iitaka, Yoichi、Inayama, Seichi

  DOI：——

  日期：——
• Inayama, Seiichi; Shimizu, Nobuko; Ohkura, Tamiko, Chemical and pharmaceutical bulletin, 1987, vol. 35, # 1, p. 429 - 432
  作者：Inayama, Seiichi、Shimizu, Nobuko、Ohkura, Tamiko、Akita, Hiroyuki、Oishi, Takeshi、Iitaka, Yoichi

  DOI：——

  日期：——
• Shimizu, Nobuko; Ohkura, Tamiko; Akita, Hiroyuki, Chemical and pharmaceutical bulletin, <hi>1989</hi>, vol. 37, # 4, p. 1023 - 1027
  作者：Shimizu, Nobuko、Ohkura, Tamiko、Akita, Hiroyuki、Oishi, Takeshi、Iitaka, Yoichi、Inayama, Seichi

  DOI：——

  日期：——