3-oxo-3-[3-[2-methyl-5-(tetrahydro-pyran-2-yloxymethyl)-thiazol-4-yl]-phenyl]-propionic acid tert-butyl ester | 473548-69-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-oxo-3-[3-[2-methyl-5-(tetrahydro-pyran-2-yloxymethyl)-thiazol-4-yl]-phenyl]-propionic acid tert-butyl ester
• 英文别名: tert-butyl 3-[3-[2-methyl-5-(oxan-2-yloxymethyl)-1,3-thiazol-4-yl]phenyl]-3-oxopropanoate
• CAS: 473548-69-5
• 化学式: C₂₃H₂₉NO₅S
• 分子量: 431.553
• InChiKey: KRGHFSYYRLWBES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  103
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3-[2-methyl-5-(tetrahydro-pyran-2-yloxymethyl)-thiazol-4-yl]-benzoic acid methyl ester 、 Lithium Tert-butyl Acetate 以to give crude 3-oxo-3-[3-[2-methyl-5-(tetrahydro-pyran-2-yloxymethyl)-thiazol-4-yl]-phenyl]-propionic acid tert-butyl ester (5.45 g) as a pale-yellow oil的产率得到3-oxo-3-[3-[2-methyl-5-(tetrahydro-pyran-2-yloxymethyl)-thiazol-4-yl]-phenyl]-propionic acid tert-butyl ester
  参考文献：
  名称：

  Dihydro-benzo [b][1,4]diazepin-2-one derivatives

  摘要：

  这项发明涉及一种二氢苯并[b][1,4]二氮杂环-2-酮衍生物，其化学式中R1、R2、R3、X和Y如规范中所定义。该发明包括含有这些化合物的制药组合物，制备这些化合物的方法，以及向需要治疗急性和/或慢性神经系统疾病的患者施用有效量的这些化合物用于制备制药组合物及治疗或预防这些疾病的方法。

  公开号：

  US06544985B2

文献信息

• Dihydro-benzo [b] [1,4] diazepin-2-one derivatives
  申请人：——

  公开号：US20020193367A1

  公开（公告）日：2002-12-19

  This invention is a dihydro-benzo[b][1,4]diazepin-2-one derivative of the formula 1 wherein R 1 , R 2 , R 3 , X and Y are as defined in the specification. The invention includes pharmaceutical compositions containing these compounds, a process for their preparation, their use in preparation of pharmaceutical compositions and administration of an effective amount of the compounds for the treatment or prevention of acute and/or chronic neurological disorders to a patient in need of such treatment.

  这项发明涉及一种公式1中R1、R2、R3、X和Y如规范中所定义的二氢苯并[b][1,4]二氮杂环-2-酮衍生物。该发明包括含有这些化合物的药物组合物、制备它们的方法、它们在制备药物组合物时的使用以及给需要这种治疗的患者施用足够剂量的这些化合物以治疗或预防急性和/或慢性神经系统疾病。
• DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1379511A1

  公开（公告）日：2004-01-14
• US6544985B2
  申请人：——

  公开号：US6544985B2

  公开（公告）日：2003-04-08
• [EN] DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II<br/>[FR] DERIVES DIHYDRO-BENZO[B][1,4]DIAZEPIN-2-ONE UTILISES COMME ANTAGONISTES DE MGLUR2(II)
  申请人：HOFFMANN LA ROCHE

  公开号：WO2002083652A1

  公开（公告）日：2002-10-24

  This invention is concerned with dihydro-benzo [b] [1, 4] diazepin-2-one derivatives of the general formula wherein R1, R2, R3 , X and Y are as defined in the specification. The invention further relates to medicaments containing these compounds, a process for their preparation as well as their use for preparation of medicaments for the treatment or prevention of acute and/or chronic neurological disorders.
• Dihydro-benzo &lsqb;b&rsqb;&lsqb;1,4&rsqb;diazepin-2-one derivatives
  申请人：Hoffman-La Roche Inc.

  公开号：US06544985B2

  公开（公告）日：2003-04-08

  This invention is a dihydro-benzo[b][1,4]diazepin-2-one derivative of the formula wherein R1, R2, R3, X and Y are as defined in the specification. The invention includes pharmaceutical compositions containing these compounds, a process for their preparation, their use in preparation of pharmaceutical compositions and administration of an effective amount of the compounds for the treatment or prevention of acute and/or chronic neurological disorders to a patient in need of such treatment.

  这项发明是一种具有以下结构的二氢苯并[b][1,4]二氮杂环己酮衍生物的公式 其中R1、R2、R3、X和Y如规范中定义。该发明包括含有这些化合物的药物组合物，其制备方法，它们在制备药物组合物和向需要此类治疗的患者施用有效量的化合物以治疗或预防急性和/或慢性神经系统疾病的用途。