(Z)-2-(bromomethyl)-1-ethoxy-4,4,5,5,6,6,6-heptafluorohex-1-en-3-one | 1526933-14-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (Z)-2-(bromomethyl)-1-ethoxy-4,4,5,5,6,6,6-heptafluorohex-1-en-3-one
• CAS: 1526933-14-1
• 化学式: C₉H₈BrF₇O₂
• 分子量: 361.054
• InChiKey: LDQXHGBXUQNQTG-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  乙基丙烯醚 在 吡啶 、 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 作用下， 以 四氯化碳 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 (Z)-2-(bromomethyl)-1-ethoxy-4,4,5,5,6,6,6-heptafluorohex-1-en-3-one
  参考文献：
  名称：

  Synthesis and Properties of α-Bromomethyl-Substituted β-Ethoxyvinyl Polyfluoroalkyl Ketones

  摘要：

  An efficient and practical method for the synthesis of -bromomethyl-substituted -alkoxyvinyl polyfluoroalkyl ketones is reported. These highly functionalized -bromomethyl enones easily react with various nucleophiles and binucleophiles affording a wide variety of new functionalized enones and heterocyclic systems that are perspective starting materials for the synthesis of compounds with potentially high biological and pharmacological activity.

  DOI：

  10.1055/s-0033-1339668

文献信息

• Synthesis and Properties of α-Bromomethyl-Substituted β-Ethoxyvinyl Polyfluoroalkyl Ketones
  作者：Igor Gerus、Maksym Bugera、Karen Tarasenko、Valery Kukhar、Gerd-Volker Röschenthaler

  DOI：10.1055/s-0033-1339668

  日期：——

  An efficient and practical method for the synthesis of -bromomethyl-substituted -alkoxyvinyl polyfluoroalkyl ketones is reported. These highly functionalized -bromomethyl enones easily react with various nucleophiles and binucleophiles affording a wide variety of new functionalized enones and heterocyclic systems that are perspective starting materials for the synthesis of compounds with potentially high biological and pharmacological activity.