3-<2-Amino-ethyl>-6-hydroxy-5-methoxy-indol, 6-Hydroxy-5-methoxy-tryptamin | 2426-82-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-<2-Amino-ethyl>-6-hydroxy-5-methoxy-indol, 6-Hydroxy-5-methoxy-tryptamin
• 英文别名: 6-Hydroxy-5-methoxy-3-(2-amino-ethyl)-indol；3-(2-amino-ethyl)-5-methoxy-indol-6-ol；3-(2-Aminoethyl)-5-methoxy-1H-indol-6-ol
• CAS: 2426-82-6
• 化学式: C₁₁H₁₄N₂O₂
• 分子量: 206.244
• InChiKey: KNQXRUNVHVEFFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  71.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-<2-Amino-ethyl>-6-hydroxy-5-methoxy-indol, 6-Hydroxy-5-methoxy-tryptamin 、 乙醛酸 在 氢氧化钾 作用下， 以 水 为溶剂， 反应 0.5h， 生成 7-hydroxy-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid
  参考文献：
  名称：

  Novel tetrahydro-β-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)

  摘要：

  A structure-activity relationship study was conducted on a series of tetrahydro-beta-carboline-1-carboxylic acid analogs in order to identify the key functionality responsible for activity against the mitogen-activated protein kinase-activated protein kinase 2 enzyme (MK-2). The compounds were further evaluated for their ability to inhibit TNF alpha production in U937 cells and in vivo. These compounds represent a novel structural class of compounds capable of inhibiting MK-2 with remarkable selectivity. (c) 2007 Elsevier Ltd. All rialuts reserved.

  DOI：

  10.1016/j.bmcl.2007.05.070
• 作为产物：
  描述：

  苏达灭 在 一水合肼 作用下， 以 水 为溶剂， 反应 14.0h， 生成 3-<2-Amino-ethyl>-6-hydroxy-5-methoxy-indol, 6-Hydroxy-5-methoxy-tryptamin
  参考文献：
  名称：

  Novel tetrahydro-β-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)

  摘要：

  A structure-activity relationship study was conducted on a series of tetrahydro-beta-carboline-1-carboxylic acid analogs in order to identify the key functionality responsible for activity against the mitogen-activated protein kinase-activated protein kinase 2 enzyme (MK-2). The compounds were further evaluated for their ability to inhibit TNF alpha production in U937 cells and in vivo. These compounds represent a novel structural class of compounds capable of inhibiting MK-2 with remarkable selectivity. (c) 2007 Elsevier Ltd. All rialuts reserved.

  DOI：

  10.1016/j.bmcl.2007.05.070

文献信息

• HAIR DYEING PROCESS USING A COMPOSITION COMPRISING AT LEAST ONE INDOLE OR INDOLINE COMPOUND, A METAL SALT, HYDROGEN PEROXIDE AND A BASIFYING AGENT
  申请人：L'Oréal

  公开号：EP2582351B1

  公开（公告）日：2017-08-02
• HAIR DYEING PROCESS USING A COMPOSITION COMPRISING AT LEAST ONE INDOL(IN)E COMPOUND AND A POLYCYCLIC AROMATIC COMPOUND CONTAINING AT LEAST TEN CARBON ATOMS
  申请人：L'OREAL

  公开号：US20180092822A1

  公开（公告）日：2018-04-05

  The invention relates to a process for dyeing keratin fibres by treating said fibres with i) at least one aromatic compound comprising a hydrocarbon-based polycycle comprising at least 10 carbon atoms, at least one of the rings of which is aromatic, ii) at least one indol(in)e compound; optionally iii) at least one metal salt, iv) at least hydrogen peroxide or at least one hydrogen peroxide-generating system and v) at least one basifying agent; to a dye composition comprising ingredients i) and ii), and optionally iii) to v) as defined previously and to a kit comprising ingredients i) to v) as defined previously. This hair dyeing process makes it possible to obtain better colorings which are more uniform, chromatic and long-lasting and which do not impair the cosmetic properties of the keratin fibres, and prevents changing of the colour associated with the presence of indol(in)e derivatives.
• [EN] HAIR DYEING PROCESS USING A COMPOSITION COMPRISING AT LEAST ONE INDOLE OR INDOLINE COMPOUND, A METAL SALT, HYDROGEN PEROXIDE AND A BASIFYING AGENT<br/>[FR] PROCÉDÉ DE COLORATION CAPILLAIRE UTILISANT UNE COMPOSITION COMPRENANT AU MOINS UN INDOLE OU UN COMPOSÉ D'INDOLINE, UN SEL MÉTALLIQUE, UN PEROXYDE D'HYDROGÈNE ET UN AGENT ALCALINISANT
  申请人：OREAL

  公开号：WO2011157668A1

  公开（公告）日：2011-12-22

  The invention relates to a process for dyeing keratin fibers, in which said fibers are treated: ▪ with a composition (A) comprising i) one or more indole or indoline compounds; ii) one or more metal salts; iii) hydrogen peroxide or one or more systems that generate hydrogen peroxide; and then ▪ with a composition (B) comprising iv) one or more basifying agents. The invention also relates to a hair dyeing process for obtaining better colorations, which are more uniform, chromatic and remanent and which do not impair the cosmetic properties of keratin fibers.
• [EN] HAIR DYEING PROCESS USING A COMPOSITION COMPRISING AT LEAST ONE INDOL(IN)E COMPOUND AND A POLYCYCLIC AROMATIC COMPOUND CONTAINING AT LEAST TEN CARBON ATOMS<br/>[FR] PROCÉDÉ DE COLORATION CAPILLAIRE UTILISANT UNE COMPOSITION CONTENANT AU MOINS UN COMPOSÉ D'INDOL(IN)E ET UN COMPOSÉ AROMATIQUE POLYCYCLIQUE COMPORTANT AU MOINS DIX ATOMES DE CARBONE
  申请人：OREAL

  公开号：WO2015181244A1

  公开（公告）日：2015-12-03

  The invention relates to a process for dyeing keratin fibres by treating said fibres with i) at least one aromatic compound comprising a hydrocarbon-based polycycle comprising at least 10 carbon atoms, at least one of the rings of which is aromatic, ii) at least one indol(in)e compound; optionally iii) at least one metal salt, iv) at least hydrogen peroxide or at least one hydrogen peroxide-generating system and v) at least one basifying agent; to a dye composition comprising ingredients i)and ii), and optionally iii) to v) as defined previously and to a kit comprising ingredients i) to v) as defined previously. This hair dyeing process makes it possible to obtain better colourings which are more uniform, chromatic and long-lasting and which do not impair the cosmetic properties of the keratin fibres, and prevents changing of the colour associated with the presence of indol(in)e derivatives.
• Novel tetrahydro-β-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)
  作者：John I. Trujillo、Marvin J. Meyers、David R. Anderson、Shridhar Hegde、Matthew W. Mahoney、William F. Vernier、Ingrid P. Buchler、Kun K. Wu、Syaluan Yang、Susan J. Hartmann、David B. Reitz

  DOI：10.1016/j.bmcl.2007.05.070

  日期：2007.8

  A structure-activity relationship study was conducted on a series of tetrahydro-beta-carboline-1-carboxylic acid analogs in order to identify the key functionality responsible for activity against the mitogen-activated protein kinase-activated protein kinase 2 enzyme (MK-2). The compounds were further evaluated for their ability to inhibit TNF alpha production in U937 cells and in vivo. These compounds represent a novel structural class of compounds capable of inhibiting MK-2 with remarkable selectivity. (c) 2007 Elsevier Ltd. All rialuts reserved.