N-对甲苯磺酰甲基甲酰胺 | 36635-56-0

• 物质功能分类: 医药中间体 - 原料药中间体
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-对甲苯磺酰甲基甲酰胺
• 中文别名: 对甲苯磺酰甲基甲酰胺
• 英文名称: N-(tosylmethyl)formamide
• 英文别名: p-toluenesulfonylmethylformamide；N-(4-methylbenzenesulfonylmethyl)-formamide；N-(p-toluenesulfonylmethyl)formamide；N-(p-tolylsulfonylmethyl)formamide；N-[(4-methylphenyl)sulfonylmethyl]formamide
• CAS: 36635-56-0
• 化学式: C₉H₁₁NO₃S
• mdl: MFCD00015915
• 分子量: 213.257
• InChiKey: XEHIIYMZJQMMCF-UHFFFAOYSA-N

物化性质

• 熔点：
  109-111 °C
• 沸点：
  486.1±45.0 °C(Predicted)
• 密度：
  1.253±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿（少许）、DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  71.6
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2924299090
• 储存条件：
  存储条件：2-8°C，干燥

SDS

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SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifiers
Product name : N-(Toluene-4-Sulfonylmethyl)-Formamide
REACH No. : A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not
require a registration or the registration is envisaged for a later
registration deadline.
CAS-No. : 36635-56-0
Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances

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SECTION 2: Hazards identification
Classification of the substance or mixture
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Label elements
The product does not need to be labelled in accordance with EC directives or respective national laws.
Other hazards
This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

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SECTION 3: Composition/information on ingredients
Substances
Formula : C9H11NO3S
Molecular weight : 213,26 g/mol
CAS-No. : 36635-56-0
No components need to be disclosed according to the applicable regulations.

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SECTION 4: First aid measures
Description of first aid measures
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
In case of skin contact
Wash off with soap and plenty of water.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
Indication of any immediate medical attention and special treatment needed
No data available

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SECTION 5: Firefighting measures
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Nature of decomposition products not known.
Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
Further information
No data available

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SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing vapours, mist or gas.
For personal protection see section 8.
Environmental precautions
No special environmental precautions required.
Methods and materials for containment and cleaning up
Sweep up and shovel. Keep in suitable, closed containers for disposal.
Reference to other sections
For disposal see section 13.

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SECTION 7: Handling and storage
Precautions for safe handling
Provide appropriate exhaust ventilation at places where dust is formed.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Storage class (TRGS 510): Non Combustible Solids
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
General industrial hygiene practice.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards
such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Choose body protection in relation to its type, to the concentration and amount of dangerous
substances, and to the specific work-place., The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Respiratory protection is not required. Where protection from nuisance levels of dusts are desired,
use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and
approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
No special environmental precautions required.

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SECTION 9: Physical and chemical properties
Information on basic physical and chemical properties
a) Appearance Form: solid
b) Odour No data available
c) Odour Threshold No data available
d) pH No data available
e) Melting point/freezing No data available
point
f) Initial boiling point and No data available
boiling range
g) Flash point No data available
h) Evaporation rate No data available
i) Flammability (solid, gas) No data available
j) Upper/lower No data available
flammability or
explosive limits
k) Vapour pressure No data available
l) Vapour density No data available
m) Relative density No data available
n) Water solubility No data available
o) Partition coefficient: n- No data available
octanol/water
p) Auto-ignition No data available
temperature
q) Decomposition No data available
temperature
r) Viscosity No data available
s) Explosive properties No data available
t) Oxidizing properties No data available
Other safety information
No data available

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SECTION 10: Stability and reactivity
Reactivity
No data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
No data available
Conditions to avoid
No data available
Incompatible materials
No data available
Hazardous decomposition products
In the event of fire: see section 5

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SECTION 11: Toxicological information
Information on toxicological effects
Acute toxicity
No data available
Skin corrosion/irritation
No data available
Serious eye damage/eye irritation
No data available
Respiratory or skin sensitisation
No data available
Germ cell mutagenicity
No data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
Additional Information
RTECS: Not available

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SECTION 12: Ecological information
Toxicity
No data available
Persistence and degradability
No data available
Bioaccumulative potential
No data available
Mobility in soil
No data available
Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other adverse effects
No data available

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SECTION 13: Disposal considerations
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.

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SECTION 14: Transport information
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
Packaging group
ADR/RID: - IMDG: - IATA: -
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
No data available

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SECTION 15: Regulatory information
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
No data available
Chemical Safety Assessment
For this product a chemical safety assessment was not carried out

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SECTION 16: Other information
Further information
Copyright 2014 Co. LLC. License granted to make unlimited paper copies for internal use
only.
The above information is believed to be correct but does not purport to be all inclusive and shall be
used only as a guide. The information in this document is based on the present state of our knowledge
and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Corporation and its Affiliates shall not be held
liable for any damage resulting from handling or from contact with the above product. See
and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

制备方法与用途

N-对甲苯磺酰甲基甲酰胺用作研究中的化合物。

反应信息

• 作为反应物：
  描述：

  N-对甲苯磺酰甲基甲酰胺 在 三乙胺 、 三氯氧磷 作用下， 以 二氯甲烷 为溶剂， 生成 对甲基苯磺酰甲基异腈
  参考文献：
  名称：

  银催化的芳基am与苄基异氰化物的[3 + 2 + 1]环化

  摘要：

  开发了银催化的with与苄基异氰化物向[2,4-二芳基-1,3,5-三嗪]的[3 + 2 + 1]环化反应。以中等到良好的产率获得了各种对称和不对称的产物。这项工作还具有2,4-二取代的三嗪的无氧化剂方法。

  DOI：

  10.1016/j.tetlet.2017.10.032
• 作为产物：
  描述：

  对甲苯磺酰氯 在 碳酸氢钠 、 sodium sulfite 作用下， 以 水 为溶剂， 反应 3.0h， 生成 N-对甲苯磺酰甲基甲酰胺
  参考文献：
  名称：

  苯基吡咯类化合物及其杀菌活性的应用

  摘要：

  本发明提供了一类新的苯基吡咯类化合物，该苯基吡咯类化合物表现出了良好的杀菌性，能够用于制备具有广谱性植物杀菌剂。并且本发明中合成路线简单，操作方便，降低了合成成本，不会对土壤、地表水和地下水等造成生态环境的污染。

  公开号：

  CN111499554B
• 作为试剂：
  描述：

  2,3,4,5-四氢吡啶 、 对甲基苯磺酰甲基异腈 在 氘代甲醇 、 N-对甲苯磺酰甲基甲酰胺 、 叔丁胺 作用下， 反应 1.5h， 以21%的产率得到5,6,7,8-tetrahydro(1,3-²H₂)imidazo[1,5-a]pyridine
  参考文献：
  名称：

  从环状亚胺和 TosMIC 合成 1,5-环稠合咪唑 - 原位生成的 N-亚甲基甲酰胺作为 van Leusen 咪唑合成中的催化剂的鉴定

  摘要：

  与 1,5 位环系统稠合的咪唑是通过 van Leusen 咪唑合成法合成的，使用饱和脂肪族三环化合物，包括在碱催化的环加成反应中与对甲苯磺酰基甲基异氰化物 (TosMIC) 的亚胺官能团。因此，发现 TosMIC 的分解产物 N-（甲苯磺酰甲基）甲酰胺可作为该反应的促进剂，从而显着缩短反应时间并提高产率。机理研究表明，在应用的碱性条件下，N-（甲苯磺酰基甲基）甲酰胺转化为 N-亚甲基甲酰胺，作为该反应的催化剂。作为迈克尔受体，使用的亚胺添加到该化合物中，从而转化为亚胺离子。如此形成的中间体促进了 van Leusen 咪唑合成的第一步，这是将去质子化的 TosMIC 添加到亚基亚基。N-亚甲基甲酰胺在整个反应过程中最终被重整，因此可以被认为是所研究的环加成反应的有机催化剂。

  DOI：

  10.1002/ejoc.202000280

文献信息

• Synthesis of chiral sulfonylmethyl isocyanides, and comparison of their propensities in asymmetric induction reactions with acetophenones1
  作者：Frans J.A. Hundscheid、Vishnu K. Tandon、Pieten H.F.M. Rouwette、Albert M. van Leusen

  DOI：10.1016/s0040-4020(01)87684-5

  日期：1987.1

  Seven chiral analogues of tosylmethyl isocyanide (TosMIC) were synthesized in order to investigate and compare their ability to achieve asymmetric induction in base mediated reactions with acetophenone and trifluoroacetophenone. Acid hydrolysis of the intermediate 2-oxazolines (10 and 11) gave optically active α-hydroxy aldehydes (12 and 13).

  为了研究和比较它们在与苯乙酮和三氟苯乙酮的碱基介导的反应中实现不对称诱导的能力，合成了七个甲苯磺酰基甲基异氰化物的手性类似物（TosMIC）。中间体2-恶唑啉（10和11）的酸解产生了光学活性的α-羟基醛（12和13）。
• Catalytic, Enantioselective α-Additions of Isocyanides:  Lewis Base Catalyzed Passerini-Type Reactions
  作者：Scott E. Denmark、Yu Fan

  DOI：10.1021/jo050549m

  日期：2005.11.1

  (Passerini-type reactions). The catalytic system of silicon tetrachloride and a chiral bisphosphoramide (R,R)-1b provided high yields and good to excellent enantioselectivities for the addition of tert-butyl isocyanide to a wide range of aldehydes (aromatic, heteroaromatic, olefinic, acetylenic, aliphatic). Aqueous workup afforded the α-hydroxy tert-butyl amides whereas a low-temperature methanol quench followed

  已经证明了异氰酸酯催化醛的对映选择性α-加成反应的普遍性（Passerini型反应）。四氯化硅和手性双磷酰胺（R，R）-1b的催化体系为叔丁基异氰酸酯加成多种醛（芳族，杂芳族，烯属，炔属，脂族）提供了高收率和良好至优异的对映选择性。水处理得到α-羟基叔胺-丁基酰胺，而低温甲醇淬灭，然后进行碱性后处理，得到α-羟基甲基酯。该反应对于其他异氰酸酯也成功，尽管对映选择性降低。发现反应条件，特别是异氰酸酯的添加速率对于良好的产率和高的选择性至关重要。
• DUAL-ACTING THIOPHENE, PYRROLE, THIAZOLE AND FURAN ANTIHYPERTENSIVE AGENTS
  申请人：Fatheree Paul R.

  公开号：US20110178101A1

  公开（公告）日：2011-07-21

  In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R 3 , R 4 and R 5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT 1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

  在一个方面，该发明涉及具有以下结构式的化合物： 其中：Ar、Z、R3、R4和R5如规范中定义，或其药用可接受盐。这些化合物具有AT1受体拮抗活性和神经氨酸酶抑制活性。在另一个方面，该发明涉及包含这些化合物的药物组合物；使用这些化合物的方法；以及制备这些化合物的过程和中间体。
• [EN] SUBSTITUTED IMIDAZO[1,5-A]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS<br/>[FR] IMIDAZO[1,5-A]PYRIMIDINES SUBSTITUÉES ET LEUR UTILISATION DANS LE TRAITEMENT DE TROUBLES MÉDICAUX
  申请人：LYSOSOMAL THERAPEUTICS INC

  公开号：WO2016073889A1

  公开（公告）日：2016-05-12

  The invention provides substituted imidazo[1,5-a]pyrimidines and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted imidazo[1,5-a]pyrimidine compounds described herein include substituted 2,4-dimethyl-N-phenylimidazo[1,5-a]pyrimidine-8-carboxamide compounds and variants thereof.

  这项发明提供了取代的咪唑并[1,5-a]嘧啶和相关的有机化合物，包含这种化合物的组合物，医疗工具包，以及使用这种化合物和组合物治疗患者的医疗疾病的方法，例如高雪氏病、帕金森病、路易体病、痴呆症或多系统萎缩症。本文描述的示例取代的咪唑并[1,5-a]嘧啶化合物包括取代的2,4-二甲基-N-苯基咪唑并[1,5-a]嘧啶-8-羧酰胺化合物及其变体。
• Unexpected Role of <i>p</i>-Toluenesulfonylmethyl Isocyanide as a Sulfonylating Agent in Reactions with α-Bromocarbonyl Compounds
  作者：Jiajia Chen、Wei Guo、Zhenrong Wang、Lin Hu、Fan Chen、Yuanzhi Xia

  DOI：10.1021/acs.joc.6b00844

  日期：2016.7.1

  The reactions of p-toluenesulfonylmethyl isocyanide (TosMIC) with α-bromocarbonyl compounds leading efficiently to α-sulfonated ketones, esters, and amides were reported, in which an explicit new role of TosMIC as the sulfonylating agent was uncovered for the first time. Mechanistic study by control experiments and DFT calculations suggested that the reaction is initiated by Cu(OTf)2-catalyzed hydration

  的反应p -toluenesulfonylmethyl胩（TOSMIC）用α-溴代化合物有效地导致α-磺化酮，酯和酰胺的报道，其中TOSMIC作为磺酰化剂的显式的新角色被揭露首次。通过对照实验和DFT计算进行的机理研究表明，该反应是由Cu（OTf）2催化的TOSMIC水合引发的，形成了甲酰胺中间体，该中间体在Cs 2 CO 3添加剂的介导下易于进行C-S键裂解。