8-fluoro-3-methyl-5H-isoxazolo[5',4':5,6]pyrido[2,3-b]indole | 1412230-41-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 8-fluoro-3-methyl-5H-isoxazolo[5',4':5,6]pyrido[2,3-b]indole
• CAS: 1412230-41-1
• 化学式: C₁₃H₈FN₃O
• 分子量: 241.224
• InChiKey: OVFKKHQJOHEFJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18.0
• 可旋转键数：
  0.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  54.71
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  (3Z)-5-fluoro-3-(3-methyl-4-nitro-isoxazol-5-yl)methylene-1,3-dihydro-2H-indol-2-one 在 铁粉 、 溶剂黄146 作用下， 反应 24.0h， 以70%的产率得到8-fluoro-3-methyl-5H-isoxazolo[5',4':5,6]pyrido[2,3-b]indole
  参考文献：
  名称：

  Synthesis and in vitro and in vivo anticancer activity of novel 3-methyl-5H-isoxazolo[5′,4′:5,6]pyrido[2,3-b]indoles

  摘要：

  A series of novel isoxazolo[5',4':5,6]pyrido[2,3-b]indoles 7a-h were synthesized and tested for their in vitro and in vivo anticancer activities. The analogs 7d and 7g have shown potential anticancer activity as compared with the reference compound Cisplatin. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.08.098

文献信息

• Synthesis and in vitro and in vivo anticancer activity of novel 3-methyl-5H-isoxazolo[5′,4′:5,6]pyrido[2,3-b]indoles
  作者：E. Rajanarendar、K. Govardhan Reddy、S. Ramakrishna、M. Nagi Reddy、B. Shireesha、G. Durgaiah、Y.N. Reddy

  DOI：10.1016/j.bmcl.2012.08.098

  日期：2012.11

  A series of novel isoxazolo[5',4':5,6]pyrido[2,3-b]indoles 7a-h were synthesized and tested for their in vitro and in vivo anticancer activities. The analogs 7d and 7g have shown potential anticancer activity as compared with the reference compound Cisplatin. (C) 2012 Elsevier Ltd. All rights reserved.