2-OMe-β-D-xylopyranose | 29198-39-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-OMe-β-D-xylopyranose
• 英文别名: 2-O-Methyl-D-xylopyranose；O²-methyl-D-xylose；O²-methyl-ξ-D-xylopyranose；2-0-Methyl-D-xylose；(3R,4S,5R)-3-methoxyoxane-2,4,5-triol
• CAS: 29198-39-8
• 化学式: C₆H₁₂O₅
• 分子量: 164.158
• InChiKey: UAXFCDNRLADBDZ-IANNHFEVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  79.2
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1,2-O-dimethyl-3,5-O-dibenzyl-α-D-xylofuranoside 生成 2-OMe-β-D-xylopyranose
  参考文献：
  名称：

  Novel d-Xylose Derivatives Stimulate Muscle Glucose Uptake by Activating AMP-Activated Protein Kinase α

  摘要：

  Type 2 diabetes mellitus has reached epidemic proportions; therefore, the search for novel antihyperglycemic drugs is intense. We have discovered that D-Xylose increases the rate of glucose transport in a non-insulin-dependent manner in rat and human myotubes in vitro. Due to the unfavorable pharmacokinetic properties Of D-Xylose we aimed at synthesizing active derivatives with improved parameters. Quantitative structure-activity relationship analysis identified critical hydroxyl groups in D-xylose. These data were used to synthesize various hydrophobic derivatives Of D-Xylose of which compound 19 the was most potent compound in stimulating the rate of hexose transport by increasing the abundance of glucose transporter-4 in the plasma membrane of myotubes. This effect resulted from the activation of AMP-activated protein kinase without recruiting the insulin transduction mechanism. These results show that lipophilic D-Xylose derivatives may serve as prototype molecules for the development of novel anti hyperglycemic drugs for the treatment of diabetes.

  DOI：

  10.1021/jm8008713

文献信息

• Coating compositions for use with an overcoated photoresist
  申请人：Shipley Co. L.L.C.

  公开号：EP1298492A2

  公开（公告）日：2003-04-02

  In a first aspect, organic coating compositions are provided, particularly spin-on antireflective coating compositions, that contain a polyester resin component. In a further aspect, coating compositions are provided that contain a resin component obtained by polymerization of a multi-hydroxy compound. Coating compositions of the invention are particularly useful employed in combination with an overcoated photoresist layer to manufacture integrated circuits.

  第一方面，提供了含有聚酯树脂成分的有机涂层组合物，特别是旋涂型减反射涂层组合物。再一方面，本发明提供的涂层组合物含有通过聚合多羟基化合物获得的树脂成分。本发明的涂层组合物与覆膜光刻胶层结合使用，特别适用于制造集成电路。
• Conditioning of SO2-ethanol-water spent liquor for fermentation by clostridia
  申请人：Api Intellectual Property Holdings, LLC

  公开号：EP2837686A1

  公开（公告）日：2015-02-18

  The present invention relates to producing chemicals and biofuels from wood material, e.g. mixed forest biomass. Specifically, the invention concerns a process for conditioning spent liquor produced by SO2-ethanol-water (SEW) fractionation of wood chips for fermentation to butanol, ethanol and acetone/isopropanol (so called ABE process) by Clostridia bacteria.

  本发明涉及利用木质材料（如混合林生物质）生产化学品和生物燃料。具体地说，本发明涉及一种调节木屑经二氧化硫-乙醇-水（SEW）分馏产生的废液的工艺，以便梭状芽孢杆菌发酵生产丁醇、乙醇和丙酮/异丙醇（即所谓的 ABE 工艺）。
• A METHOD FOR OBTAINING A LIGNIN OIL COMPOSITION USING A COMPRESSED GAS AND ACID ASSISTED PROCESS
  申请人：Vertoro B.V.

  公开号：EP3798286A1

  公开（公告）日：2021-03-31

  The present invention relates to a process for the production of a liquid lignin composition, in particular to a method for obtaining a lignin composition using a compressed gas and acid assisted process, wherein a lignocellulosic biomass feedstock is treated with a polar organic solvent using an inorganic acid to assist in the release of lignin into the polar organic solvent and the use of compressed gas to keep the polar organic solvent in its liquid phase.

  本发明涉及一种生产液态木质素组合物的工艺，特别是涉及一种使用压缩气体和酸辅助工艺获得木质素组合物的方法，其中木质纤维素生物质原料用极性有机溶剂处理，使用无机酸帮助木质素释放到极性有机溶剂中，并使用压缩气体使极性有机溶剂保持液相。
• Pentose derivatives as anti-hyperglycemic drugs
  申请人：Sasson Shlomo

  公开号：US20050277599A1

  公开（公告）日：2005-12-15

  The present invention relates to pentose and pentose derivatives that are effective at increasing glucose transport in a non-insulin dependent manner, and to uses thereof for a) treating and/or preventing hyperglycemia; b) treating and/or preventing the complications of hyperglycemia; c) treating diabetes; d) increasing the rate of cellular glucose transport; e) increasing the rate of cellular glucose uptake; f) improving the ability of a subject to metabolize glucose; g) treating daily blood glucose fluctuations; h) reducing blood sugar levels; i) reducing the dosage of anti-diabetic medication needed for treatment of diabetes. The present invention further provides novel pentose derivatives having beneficial properties in terms of pharmacokinetics, to pharmaceutical compositions comprising these novel compounds and uses thereof.

  本发明涉及以非胰岛素依赖方式有效增加葡萄糖转运的戊糖和戊糖衍生物，并涉及其用于 a) 治疗和/或预防高血糖；b) 治疗和/或预防高血糖并发症；c) 治疗糖尿病；d) 增加细胞葡萄糖转运率； e) 增加细胞葡萄糖摄取率； f) 改善受试者代谢葡萄糖的能力； g) 治疗日常血糖波动； h) 降低血糖水平； i) 减少治疗糖尿病所需的抗糖尿病药物剂量。本发明进一步提供了在药代动力学方面具有有益特性的新型戊糖衍生物，以及包含这些新型化合物的药物组合物及其用途。
• ASPERGILLUS ARABINOFURANOSIDASE
  申请人：DANISCO A/S

  公开号：EP0871745A1

  公开（公告）日：1998-10-21