3-Butyl-4-pent-(Z)-ylidene-oxetan-2-one | 5659-17-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 3-Butyl-4-pent-(Z)-ylidene-oxetan-2-one
• 英文别名: (4Z)-3-butyl-4-pentylideneoxetan-2-one
• CAS: 5659-17-6
• 化学式: C₁₂H₂₀O₂
• 分子量: 196.29
• InChiKey: MJZLRAHODCHJCG-LUAWRHEFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-Butyl-4-pent-(Z)-ylidene-oxetan-2-one 在 硫酸 作用下， 以 苯 为溶剂， 生成 7-Bromo-3-butyl-4-pentyl-1H-quinolin-2-one
  参考文献：
  名称：

  Controlled molecular aggregation. 1. Cyclic trimerization via hydrogen bonding

  摘要：

  Vapor pressure osmometric and H-1 NMR dilution studies of quinolone 7, isoquinolone 8, and pyrido[4,3-g]quinolinedione 1, indicate that 1 forms an extremely robust cyclic trimer in solution.

  DOI：

  10.1021/jo00034a005

文献信息

• Novel method for the asymmetric synthesis of beta-lactone compounds
  申请人：Smith W. Jeffrey

  公开号：US20060258620A1

  公开（公告）日：2006-11-16

  The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis. The invention also features methods of synthesizing beta-lactones and features novel beta-lactone compounds.

  本发明涉及通过向患者施用有效量的β-内酰胺来治疗患者身上的癌症的方法。本发明还涉及通过向患者施用脂肪酸合成酶抑制剂的有效量来抑制患者身上的血管生成的方法。这些方法可以用于治疗各种癌症和其他疾病和病况。本发明还涉及识别β-内酰胺和其他化合物的方法，这些化合物可以用于本发明中用于治疗肿瘤、抑制血管生成以及治疗涉及病理性血管生成的疾病和病况的方法。本发明还涉及合成β-内酰胺的方法和新型β-内酰胺化合物的特点。
• NOVEL METHOD FOR THE ASYMMETRIC SYNTHESIS OF BETA-LACTONE COMPOUNDS
  申请人：Smith Jeffrey W.

  公开号：US20100173982A1

  公开（公告）日：2010-07-08

  The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis. The invention also features methods of synthesizing beta-lactones and features novel beta-lactone compounds.

  本发明涉及通过向受试者施用有效量的β-内酰胺来治疗癌症的方法。本发明还涉及通过向受试者施用脂肪酸合成酶抑制剂的有效量来抑制血管生成的方法。这些方法可用于治疗各种癌症和其他疾病和病况。本发明还涉及识别β-内酰胺和其他化合物的方法，这些化合物可用于本发明的治疗肿瘤、抑制血管生成以及涉及病理性血管生成的疾病和病况的方法。本发明还涉及β-内酰胺的合成方法和新型β-内酰胺化合物。
• Synthesis, Structure, and Reactivity of Unexpectedly Stable Spiroepoxy-β-Lactones Obtained by Epoxidation of 4-Alkylidene-2-Oxetanones
  作者：Richard J. Duffy、Kay A. Morris、Daniel Romo

  DOI：10.1021/ja053478h

  日期：2005.12.1

  We describe the first synthesis of spiroepoxy-beta-lactones obtained via epoxidation of ketene dimers. These compounds display unexpected stability that may be due to a double anomeric effect garnered from analysis of bond lengths by X-ray crystallography of one spirocycle in comparison to calculated bond lengths of related structures. These new strained intermediates display interesting reactivity leading to a butenolide, an alpha-hydroxyketone, a triol, an alpha-chloroketone, and an alpha-azidoketone.
• ZAVYALOV, S. I.;SITKAREVA, I. V., IZV. AN CCCP. CEP. XIM., 1985, N 5, 1071-1074
  作者：ZAVYALOV, S. I.、SITKAREVA, I. V.

  DOI：——

  日期：——
• WATER REPELLENT COMBINATIONS
  申请人：Janssen Pharmaceutica NV

  公开号：US20180334571A1

  公开（公告）日：2018-11-22

  The present invention concerns combinations of a water repellent alkyl ketene dimer as a component (I) and a water repellent metal alcoholate as a component (II) that are strongly synergistic in repelling water from water absorbing surfaces, resulting in a surprisingly long water droplet absorption time. The combinations of the invention can be applied to the surface of any material that has water absorbing properties such as, but not limited to, wood, woven and non-woven sheeting materials, paper, building materials, gypsum board, and leather.