2-N,6-O-disulfo-D-glucosamine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-N,6-O-disulfo-D-glucosamine
• 英文别名: [(2R,3R,4S,5R)-3,4,5-trihydroxy-1-oxo-6-sulfooxyhexan-2-yl]sulfamic acid
• 化学式: C₆H₁₃NO₁₁S₂
• 分子量: 339.3
• InChiKey: BQSMUQUKNCGJCT-SLPGGIOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.5
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  225
• 氢给体数：
  6
• 氢受体数：
  12

文献信息

• Oligosaccharide having affinity for fibroblast growth factor and process for producing same
  申请人：SEIKAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP0509517A2

  公开（公告）日：1992-10-21

  An oligosaccharide having an affinity for fibroblast growth factor, which is composed of 8 to 18 monosaccharide residues, wherein a principal disaccharide unit comprising L-iduronic acid 2-sulfate and N-sulfo-D-glucosamine and a process for producing the oligosaccharide comprising digesting heparan sulfate.

  一种对成纤维细胞生长因子具有亲和力的寡糖，它由 8 至 18 个单糖残基组成，其中一个主二糖单元由 L-iduronic acid 2-sulfate 和 N-sulfo-D-glucosamine 组成，生产该寡糖的工艺包括消化硫酸肝素。
• LOW-MOLECULAR HEPARIN MODIFICATION AND REMEDY FOR SKIN ULCER
  申请人：Yamashina, Ikuo

  公开号：EP1033375A1

  公开（公告）日：2000-09-06

  A heparin derivative having an excellent effect of remedying skin ulcer and a skin ulcer remedy containing the same. The heparin derivative refers to a heparin modification and/or a low-molecular heparin modification and serves as a skin ulcer remedy after being deprived to the anticoagulant activity while retaining the ability to bind to cell growth factors, cytokines or cell adhesion factors.

  一种具有极佳皮肤溃疡补救效果的肝素衍生物和一种含有该衍生物的皮肤溃疡补救剂。肝素衍生物是指一种肝素修饰物和/或一种低分子肝素修饰物，在失去抗凝活性后可作为皮肤溃疡治疗剂，同时保留与细胞生长因子、细胞因子或细胞粘附因子结合的能力。
• Sulfohydrolase I from Chondrus crispus seaweed, and uses thereof
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

  公开号：EP1428884A1

  公开（公告）日：2004-06-16

  The present invention relates to an isolated sulfohydrolase from Chondrus crispus seaweed, comprising an amino acid sequence of SEQ ID NO:22, and uses thereof for enzymatically modifying sulfated compounds.

  本发明涉及一种从 Chondrus crispus SEaweed 分离出来的硫醇水解酶，其氨基酸序列为 SEQ ID NO:22，以及利用其对硫酸盐化合物进行酶解修饰的用途。
• Use of glycosaminoglycans to reduce non-specific binding in immunoassays
  申请人：ORTHO-CLINICAL DIAGNOSTICS, INC.

  公开号：EP2031392A1

  公开（公告）日：2009-03-04

  An immunoassay reagent is provided which comprises an analyte binding agent in a diluent, and a glycosaminoglycan in an amount sufficient to reduce non-specific binding in an assay of a sample for the analyte. Provided is such an immunoassay reagent in which the analyte is troponin I, the analyte binding agent is a biotinylated anti-troponin I antibody, and the glycosaminoglycan is chondroitin sulfate. A sample composition is also provided which comprises a sample to be assayed for the presence of an analyte, an analyte binding agent, and a glycosaminoglycan other than heparin. Further provided is a method of detecting an analyte in a sample, in which non-specific binding is reduced in the method using a glycosaminoglycan.

  提供了一种免疫测定试剂，它包括稀释剂中的分析物结合剂和糖胺聚糖，其用量足以在分析样品时减少非特异性结合。提供了这样一种免疫测定试剂，其中分析物是肌钙蛋白 I，分析物结合剂是生物素化的抗肌钙蛋白 I 抗体，糖胺聚糖是硫酸软骨素。还提供了一种样品组合物，其中包括待检测的分析物、分析物结合剂和肝素以外的糖胺聚糖。还提供了一种检测样品中分析物的方法，在该方法中使用糖胺聚糖可减少非特异性结合。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。