Pneumosamine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Pneumosamine
• 英文别名: (2S,3R,4S,5R)-2-amino-3,4,5-trihydroxyhexanal
• 化学式: C₆H₁₃NO₄
• 分子量: 163.17
• InChiKey: NTBYIQWZAVDRHA-ARQDHWQXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Polysaccharide antigens from streptococcus pneumoniae
  申请人：MERCK & CO. INC.

  公开号：EP0497524A2

  公开（公告）日：1992-08-05

  Type-specific capsular polysaccharide preparations from Streptococcus pneumoniae, having on average less than about 1000 oligosaccharide repeat units per molecule, polydispersities between 1.0 and 1.4, intrinsic viscosities between 0.6 and 3.0 dL/g, and less than 3% contamination of type-specific polysaccharide by group-specific C-polysaccharide, are produced by a novel process. The novel type specific polysaccharide products are useful in the preparation of vaccines, especially covalent conjugates comprising the novel polysaccharide linked to a T-cell stimulatory carrier protein. Vaccines comprising the novel polysaccharides are useful in the prevention of infection and of diseases associated with infection by Streptococcus pneumoniae.

  肺炎链球菌的型特异性荚膜多糖制剂是通过一种新工艺生产的，平均每个分子中的寡糖重复单位少于约 1000 个，多分散度在 1.0 到 1.4 之间，固有粘度在 0.6 到 3.0 dL/g 之间，型特异性多糖被群体特异性 C 多糖污染的程度低于 3%。新型特异性多糖产品可用于制备疫苗，特别是由新型多糖与刺激 T 细胞的载体蛋白连接而成的共价结合物。由新型多糖组成的疫苗可用于预防肺炎链球菌感染以及与肺炎链球菌感染相关的疾病。
• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。
• Pneumococcal polysaccharide conjugate vaccine
  申请人：Merck & Co., Inc.

  公开号：EP0497525B1

  公开（公告）日：1998-08-19
• PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING
  申请人：ENEVOLV, INC.

  公开号：US20160186168A1

  公开（公告）日：2016-06-30

  The present disclosure provides compositions and methods for genomic engineering.
• US5541341A
  申请人：——

  公开号：US5541341A

  公开（公告）日：1996-07-30