抗生素类抗肿瘤药
这是一种具有杀灭肿瘤细胞作用的抗生素，属于细胞周期非特异性药物。根据其作用机理，可以分为两类：一是直接与DNA交叉结合，破坏DNA结构与功能，阻止DNA复制的抗生素，如丝裂霉素和博莱霉素；二是嵌入DNA中干扰模板功能，抑制RNA合成的抗生素，如放线菌素D、正定霉素和阿霉素。
| 中文名称 | 英文名称 | CAS号 | 化学式 |
|---|---|---|---|
| 阿霉素 | doxorubicin | 23214-92-8 | C27H29NO11 |
| 阿克拉霉素 | aclacinomycin A | 57576-44-0 | C42H53NO15 |
| 链黑霉素 | streptonigrin | 3930-19-6 | C25H22N4O8 |
| 道诺霉素 | DNR | 20830-81-3 | C27H29NO10 |
| 表阿霉素 | Epirubicin | 56420-45-2 | C27H29NO11 |
| 色霉素A3 | chromomycin A3 | 7059-24-7 | C57H82O26 |
| 硫酸博莱霉素 | Bleomycin hydrochloride | 9041-93-4 | C55H84N17O21S3+ |
| 盐酸阿柔比星 | hydron;methyl (1R,2R,4S)-4-[(2R,4S,5S,6S)-4-(dimethylamino)-5-[(2S,4S,5S,6S)-4-hydroxy-6-methyl-5-[(2R,6S)-6-methyl-5-oxooxan-2-yl]oxyoxan-2-yl]oxy-6-methyloxan-2-yl]oxy-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate;chloride | 75443-99-1 | C42H54ClNO15 |
| 盐酸表柔比星 | epirubicin Hydrochloride | 56390-09-1 | C27H29NO11*ClH |
| 盐酸平阳霉素 | Bleomycin A5 Hydrochloride(1:x) | 55658-47-4 | C57H90ClN19O21S2 |
| 盐酸多柔比星 | doxorubicin hydrochloride | 25316-40-9 | C27H30NO11*Cl |
| 盐酸依达比星 | idarubicin hydrochloride | 57852-57-0 | C26H27NO9*ClH |
| 派来霉素 | peplomycin | 68247-85-8 | C61H88N18O21S2 |
| 柔红霉素 盐酸盐 | daunomycin hydrochloride | 23541-50-6 | C27H29NO10*ClH |
| 柔红霉素 | Daunorubicinol | 28008-55-1 | C27H31NO10 |
| 更生霉素 | actinomycin D | 50-76-0 | C62H86N12O16 |
| 放线菌素C | 2-amino-1-N-[(3S,6S,7R,10S,16S)-3-[(2S)-butan-2-yl]-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-10-propan-2-yl-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]-4,6-dimethyl-3-oxo-9-N-[(3S,6S,7R,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide | 8052-16-2 | C63H88N12O16 |
| 抗生素MA144-A1 | Aclacinomycin A | 57576-44-0 | C42H53NO15 |
| 戊柔比星 | valrubicin | 56124-62-0 | C34H36F3NO13 |
| 含氮霉素 | (-)-azotomycin | 7644-67-9 | C17H23N7O8 |
| 吡柔比星 | Pirarubicin | 72496-41-4 | C32H37NO12 |
| 博来霉素 A5 | Bleomycin A5 | 11116-32-8 | C57H89N19O21S2 |
| 光辉霉素 | mithramycin | 18378-89-7 | C52H76O24 |
| 伊达比星 | idarubicin | 58957-92-9 | C26H27NO9 |
| 丝裂霉素 C | mitomycin C | 50-07-7 | C15H18N4O5 |
| —— | Aclarubicin | 64520-15-6 | C42H53NO15 |
| —— | [(3S,4S,5R,6R)-2-[(2R,3S,4S,5S,6S)-2-[(1R,2S)-2-[[6-amino-2-[(1S)-3-amino-1-[[(2S)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[(2R,3S,4R)-5-[[(3R)-1-[2-[4-[4-[3-(4-aminobutylamino)propylcarbamoyl]-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-4-methyl-5-oxopentan-2-yl]amino]-1-(1H-imidazol-5-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl] carbamate;hydrochloride | 55658-47-4 | C57H90ClN19O21S2 |
| —— | 13-dihydrodaunorubicin | 28008-55-1 | C27H31NO10 |
| —— | (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-2-yl)-alpha-L-arabino-hexopyranoside | 70287-21-7 | C32H37NO12 |
| —— | (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-2-yl)-alpha-L-arabino-hexopyranoside | 70287-21-7 | C32H37NO12 |
| —— | N-trifluoroacetyl doxorubicin-14-valerate | 56124-62-0 | C34H36F3NO13 |
| —— | 13-(R,S)-dihydrodaunorubicin | 28008-55-1 | C27H31NO10 |
| —— | 3-[[2-[2-[2-[[(2S,3R)-2-[[(2S,3S,4R)-4-[[(2S,3R)-2-[[6-amino-2-[(1S)-3-amino-1-[[(2S)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2R,3S,4S,5R,6R)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]ethyl]-1,3-thiazol-4-yl]-1,3-thiazole-4-carbonyl]amino]propyl-dimethylsulfanium;hydrochloride | 67763-87-5 | C55H85ClN17O21S3+ |
| —— | (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-6-methyl-5-[(2S)-oxan-2-yl]oxyoxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione | 72496-41-4 | C32H37NO12 |
| —— | (9S)-7-[(2R,4S,5S,6S)-4-amino-6-methyl-5-[(2R)-oxan-2-yl]oxyoxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione | 72496-41-4 | C32H37NO12 |
| —— | Mitramycin | 18378-89-7 | C52H76O24 |
| —— | Sodium azotomycin | 7644-67-9 | C17H25N7O8+2 |
| —— | (9S)-7-[4-amino-6-methyl-5-(oxan-2-yloxy)oxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione | 72496-41-4 | C32H37NO12 |
| —— | pirarubicin | 72496-41-4 | C32H37NO12 |
| —— | cinerulose | 57576-44-0 | C42H53NO15 |
| —— | methyl (1R,2R,4S)-4-[(2S,4S,5R,6R)-4-(dimethylamino)-5-[(2R,4S,5R,6R)-4-hydroxy-6-methyl-5-[(2S,6R)-6-methyl-5-oxooxan-2-yl]oxyoxan-2-yl]oxy-6-methyloxan-2-yl]oxy-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate | 57576-44-0 | C42H53NO15 |
| —— | acurarubicin | 57576-44-0 | C42H53NO15 |
| —— | Daunomycin; RP 13057; Rubidomycin | 23541-50-6 | C27H29NO10.HCl |
| —— | (9R)-7-[(2S,4R,5R,6R)-4-amino-6-methyl-5-[(2R)-oxan-2-yl]oxyoxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione | 72496-41-4 | C32H37NO12 |
| —— | Aclacin | 57576-44-0 | C42H53NO15 |
| —— | 3-[[2-[2-[2-[[(2R,3R)-2-[[(2R,3R,4S)-4-[[(2S)-2-[[6-amino-2-[(1S)-3-amino-1-[[(2R)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2S,3R,4R,5R,6R)-3-[(2R,3S,4S,5R,6R)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]ethyl]-1,3-thiazol-4-yl]-1,3-thiazole-4-carbonyl]amino]propyl-dimethylsulfanium | 9041-93-4 | C55H84N17O21S3+ |
| —— | 3-[[2-[2-[2-[[(2S,3R)-2-[[(2S,3S,4R)-4-[[(2S,3R)-2-[[6-amino-2-[(1S)-3-amino-1-[[(2S)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2R,3S,4S,5R,6R)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]ethyl]-1,3-thiazol-4-yl]-1,3-thiazole-4-carbonyl]amino]propyl-dimethylsulfanium;sulfuric acid | 9041-93-4 | C55H86N17O25S4+ |
| —— | 2-amino-4,6-dimethyl-3-oxo-1-N-[(3R,6S,7R,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]-9-N-[(3R,6S,7R,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide | 50-76-0 | C62H86N12O16 |
| —— | (7R,9R)-9-acetyl-7-[(2S,4R,5R,6R)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride | 23541-50-6 | C27H30ClNO10 |
| —— | Diazomycin B | 7644-67-9 | C17H23N7O8 |
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