中草药化学是运用现代化学理论和方法研究中草药中的化学成分的科学。这些成分复杂多样,包括糖类、氨基酸、蛋白质、油脂、蜡、酶、色素、维生素、有机酸、鞣质、无机盐、挥发油、生物碱和苷类等。每种中草药通常含有多种化学成分。
其中,具有明显生物活性并能发挥医疗作用的成分称为有效成分,如生物碱、苷类、挥发油及氨基酸等。因此,许多中草药之所以具备医疗效果,主要归因于它们的有效成分,例如黄连中的抗菌消炎小檗碱(黄连素)、麻黄中的平喘麻黄碱和萝芙木中的降压成分利血平等。
除此之外,还有一些在中草药里普遍存在但通常没有生物活性、不起医疗作用的成分,称为“无效成分”,如糖类、蛋白质、色素、树脂及无机盐等。不过,在有效与无效之间并没有绝对界限,有些原来被认为是无效的成分后来因发现其具有生物活性而成为有效成分。
近代科学的发展使得各种精密分离方法趋向快速定量,这使中草药化学成分的研究更加深入。尤其是气相层析和质谱法联用技术的应用,将分离、纯化和鉴定步骤合并,大大提高了结构测定的速度与准确性,并为中草药化学研究提供了广阔前景。
自20世纪50年代以来,由于从民间药材萝芙木中发现了降低血压的生物碱利血平,以及从长春花中发现了抗癌有效成分长春碱,国际科学界重新重视对民间植物药材的研究。尤其是各国竞相从植物药材中筛选出抗癌有效成分,国内如从青蒿中发现速效抗疟药青蒿素,从仙鹤草根芽中分离出具有良好驱绦虫作用的鹤草酚等都证明了中草药化学的进步。
未来,在重大疾病治疗药物研究方面,预计会从植物成分中获得新的突破。在这一基础上,植物组织培养作为一种新学科应运而生,旨在通过人工培养来定向产生大量有利于工业生产的有效成分。例如人参的组织培养粗皂苷含量高达21%。
此外,化学植物分类学的发展也促进了对植物代谢产物(化学成分)分布规律的研究,这将有助于从化学成分的角度研究植物亲缘关系,并为植物成分生物合成途径提供新的研究方法。
中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
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—— | (1S,4R,9R,11S)-9-tert-butyl-7,9-dihydroxy-3,5,12-trioxatetracyclo[6.6.0.01,11.04,8]tetradecane-2,6,13-trione | 33570-04-6 | C15H18O8 |
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—— | Silydianin | 29782-68-1 | C25H22O10 |
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—— | (4R)-2,6,6-trimethyl-4-[(2R,4S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycyclohexene-1-carbaldehyde | 138-55-6 | C16H26O7 |
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—— | theaflavin 3-gallate | 28543-07-9 | C36H28O16 |
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—— | (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS,13bR)-9-hydroxy-8-(hydroxymethyl)-5a,5b,8,11a-tetramethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid | 85999-40-2 | C30H48O4 |
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—— | bis[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl] (2E,4E,6E,8E,10Z,12E,14Z)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate | 42553-65-1 | C44H64O24 |
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—— | N-[(7S)-1,2,10-trimethoxy-9-oxo-3-[(3R,4S,5S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide | 477-29-2 | C27H33NO11 |
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—— | (1R,5S,8S,9R,13R,14S)-1-hydroxy-13-methyl-14-prop-1-en-2-yl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione | 17617-45-7 | C15H16O6 |
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—— | [(2R,3R,4R,5R,6S,7S,8R,13R,14R,16S,17S,18R)-8-acetyloxy-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-methyl-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate | 2752-64-9 | C33H45NO11 |
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—— | (2S,3R,4R,5R,6S)-2-[(3R,4S,5S)-4-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-[[(2R,5R,7S,10R,11R,14R,15S,16S,18R,20S)-16-hydroxy-2,6,6,10,16-pentamethyl-18-(2-methylprop-1-enyl)-19,21-dioxahexacyclo[18.2.1.01,14.02,11.05,10.015,20]tricosan-7-yl]oxy]oxan-3-yl]oxy-6-methyloxane-3,4,5-triol | 55466-04-1 | C58H94O26 |
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—— | D-Pinitol | 10284-63-6 | C7H14O6 |
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—— | [4-hydroxy-6-methyl-8-oxo-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-7-oxatricyclo[4.3.0.03,9]nonan-9-yl]methyl benzoate | 39011-90-0 | C23H28O11 |
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—— | 3-{2-[(4aS,5R,8aS)-5,8a-Dimethyl-2-methylene-5-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxymethyl)-decahydro-naphthalen-1-yl]-ethyl}-5H-furan-2-one | 27215-14-1 | C26H40O8 |
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—— | 2,3,11,14,20,22,25-Heptahydroxycholest-7-en-6-one | 137476-71-2 | C27H44O8 |
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—— | [(1R,2S,5R,6S,7S,8R,9S,10S,11R)-10-acetyloxy-6,7,9,18-tetrahydroxy-12,12-dimethyl-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-6-yl]methyl acetate | 102641-82-7 | C24H36O9 |
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—— | Lucigenin | 2315-97-1 | C28H22N4O6 |
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—— | Laurifolin | 7224-61-5 | C20H24NO4 |
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—— | (1R,5S,8S,13R,14R)-1-Hydroxy-13-methyl-14-prop-1-en-2-yl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione | 17617-45-7 | C15H16O6 |
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—— | Telocinobufagin | 472-26-4 | C24H34O5 |
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—— | α-Spinasterol | 481-18-5 | C29H48O |
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—— | (-)-scopolamine hydrochloride | 55-16-3 | C17H21NO4*ClH |
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—— | Alvonal MR | 508-77-0 | C30H44O9 |
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—— | (3R)-2-(3,4-dihydroxyphenyl)chromane-3,5,7-triol | 490-46-0 | C15H14O6 |
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—— | 3'-O-Methyl-evomonoside | 466-07-9 | C30H46O8 |
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—— | methyl (1S,4aS,6S,7R,7aS)-6-hydroxy-7-methyl-1-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate | 18524-94-2 | C17H26O10 |
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—— | Rhodotoxine | 4720-09-6 | C22H36O7 |
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—— | [(1'S,3'R,4'R,5'R,6'R,10'S,12'S,16'R,18'S,21'R)-2-hydroxy-1,4',6',12',17',17'-hexamethyl-18'-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyspiro[3,6-dioxabicyclo[3.1.0]hexane-4,8'-9-oxahexacyclo[11.9.0.01,21.04,12.05,10.016,21]docos-13-ene]-3'-yl] acetate | 66176-93-0 | C37H54O11 |
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—— | (3R)-2-aminooctadecane-1,3-diol | 3102-56-5 | C18H39NO2 |
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—— | (2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-5-hydroxy-2-(3-hydroxy-4-methoxy-phenyl)chroman-4-one | 13241-33-3 | C28H34O15 |
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—— | chasmanine | 5066-78-4 | C25H41NO6 |
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—— | juvenile hormone II | 34218-61-6 | C17H28O3 |
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—— | (1R,3R,5S,8S,9S,12R,13R,14R)-1-hydroxy-13-methyl-14-prop-1-en-2-yl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione | 17617-45-7 | C15H16O6 |
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—— | yunaconitine | 70578-24-4 | C35H49NO11 |
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—— | 1,3,4,6,6a,7,8,9,10,12,13,13a-Dodecahydro-2H-6,13-methanodipyrido[1,2-a:3',2'-e]azocine | 56293-29-9 | C15H24N2 |
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—— | (1R,3R,6R,7R,10R)-3-hydroxy-10-(4-hydroxy-3-methoxyphenyl)-8-[(2R)-3,5,7-trihydroxy-4-oxo-2,3-dihydrochromen-2-yl]-4-oxatricyclo[4.3.1.03,7]dec-8-en-2-one | 29782-68-1 | C25H22O10 |
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—— | Rhynchophyllin | 76-66-4 | C22H28N2O4 |
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—— | wuweizisu C | 61301-33-5 | C22H24O6 |
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—— | [(3'S,4'R,5'R,6'R,10'S,12'S,21'R)-2-hydroxy-1,4',6',12',17',17'-hexamethyl-18'-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyspiro[3,6-dioxabicyclo[3.1.0]hexane-4,8'-9-oxahexacyclo[11.9.0.01,21.04,12.05,10.016,21]docos-13-ene]-3'-yl] acetate | 66176-93-0 | C37H54O11 |
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—— | (2R,6S)-6-[(3S,5R,10S,12S,13R,14R,17R)-12-acetyloxy-3-hydroxy-4,4,10,13,14-pentamethyl-7,11,15-trioxo-1,2,3,5,6,12,16,17-octahydrocyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoic acid | 98665-19-1 | C32H44O9 |
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—— | (1R,3R,6R,7R,10S)-3-hydroxy-10-(4-hydroxy-3-methoxyphenyl)-8-[(2R,3R)-3,5,7-trihydroxy-4-oxo-2,3-dihydrochromen-2-yl]-4-oxatricyclo[4.3.1.03,7]dec-8-en-2-one | 29782-68-1 | C25H22O10 |
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—— | Rhaponticine | 155-58-8 | C21H24O9 |
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—— | Rhapontin; 3,5,3'-Trihydroxy-4'-methoxy-stilben-3-β-D-glucosid | 155-58-8 | C21H24O9 |
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—— | Rhapontizin | 155-58-8 | C21H24O9 |
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—— | rhaponticin | 155-58-8 | C21H24O9 |
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—— | Raphanin | 2404-46-8 | C6H9NOS2 |
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—— | Libanotin | 15591-75-0 | C21H22O7 |
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—— | Picrocrocin | 138-55-6 | C16H26O7 |
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—— | (9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl) (2S)-3-hydroxy-2-phenylpropanoate;hydrochloride | 55-16-3 | C17H22ClNO4 |
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—— | cucurbitacin E | 2612-95-5 | C32H44O8 |
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—— | Schisantherin B | 58546-55-7 | C28H34O9 |
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