(3S,6R,7S,10R)-3-Ethyl-7-isopropyl-5-(4-methoxy-phenyl)-10-methyl-1-oxa-5-aza-spiro[5.5]undecane-2,4-dione | 141514-68-3

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: (3S,6R,7S,10R)-3-Ethyl-7-isopropyl-5-(4-methoxy-phenyl)-10-methyl-1-oxa-5-aza-spiro[5.5]undecane-2,4-dione
• CAS: 141514-68-3
• 化学式: C₂₂H₃₁NO₄
• 分子量: 373.492
• InChiKey: NIHDRMKFHRFZFJ-JHGBEIFQSA-N

反应信息

• 作为反应物：
  描述：

  (3S,6R,7S,10R)-3-Ethyl-7-isopropyl-5-(4-methoxy-phenyl)-10-methyl-1-oxa-5-aza-spiro[5.5]undecane-2,4-dione 在 sodium hydride 、 1-氟-2,4,6-三甲基吡啶三氟甲烷磺酸盐 作用下， 生成 (3S,6R,7S,10R)-3-Ethyl-3-fluoro-7-isopropyl-5-(4-methoxy-phenyl)-10-methyl-1-oxa-5-aza-spiro[5.5]undecane-2,4-dione
  参考文献：
  名称：

  Use of 1,3-Dioxin-4-ones and Their Related Compounds in Synthesis. Part 35. Synthesis of Optically Pure Fluoromalonamic Acids by Means of Asymmetric Fluorination of Chiral 1,3-Oxazine-4,6-diones

  摘要：

  Fluorination of chiral 5-substituted 1,3-oxazine-4,6-dione derivatives proceeded stereoselectively to give the 5-fluorooxazinediones, which were readily transformed to optically pure fluoromalonamic acids.

  DOI：

  10.3987/com-91-s33