Acetic acid (1R,7R,12R)-7,12-dihydroxy-12-[(2R,5R)-5-((R)-1-hydroxy-tridecyl)-tetrahydro-furan-2-yl]-1-(6-methyl-3-oxo-2-phenyl-2,3-dihydro-pyridazin-4-ylmethyl)-dodecyl ester | 209053-03-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Acetic acid (1R,7R,12R)-7,12-dihydroxy-12-[(2R,5R)-5-((R)-1-hydroxy-tridecyl)-tetrahydro-furan-2-yl]-1-(6-methyl-3-oxo-2-phenyl-2,3-dihydro-pyridazin-4-ylmethyl)-dodecyl ester
• CAS: 209053-03-2
• 化学式: C₄₃H₇₀N₂O₇
• 分子量: 727.038
• InChiKey: ODFNHWORLTVFKB-GIEDQAFWSA-N

物化性质

• 沸点：
  811.086±75.00 °C(Press: 760.00 Torr)(predicted)
• 密度：
  1.119±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  (S)-(-)-α-甲氧基-α-(三氟甲基)苯乙酸 、 Acetic acid (1R,7R,12R)-7,12-dihydroxy-12-[(2R,5R)-5-((R)-1-hydroxy-tridecyl)-tetrahydro-furan-2-yl]-1-(6-methyl-3-oxo-2-phenyl-2,3-dihydro-pyridazin-4-ylmethyl)-dodecyl ester 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 生成
  参考文献：
  名称：

  Two Epimeric Pairs of C-4-Acetyl Annonaceous Acetogenins fromGoniothalamus donnaiensis

  摘要：

  Further studies on the roots of Goniothalamus donnaiensis Finet et Gagnap (Annonaceae) led to the isolation of two pairs of Annonaceous acetogenins, donnaienin C (1) and 34-epi-donnaienin C (1′), donnaienin D (2) and 34-epi-donnaienin D (2′), containing a rare γ-hydroxymethyl-γ-lactone moiety and a C-4-acetoxy group. Their structures were elucidated by spectral data and chemical derivatization. Preliminary pharmacological tests showed that the mixture of donnaienin C(1) and 34-epi-donnaienin C (1′) inhibited human hepatoma (Bel) cell lines in vitro (IC50, 7.1 µg/ml).

  DOI：

  10.1055/s-2006-957452
• 作为产物：
  描述：

  苯肼 、 Acetic acid (1R,7R,12R)-7,12-dihydroxy-1-(5-hydroxy-5-methyl-2-oxo-2,5-dihydro-furan-3-ylmethyl)-12-[(2R,5R)-5-((R)-1-hydroxy-tridecyl)-tetrahydro-furan-2-yl]-dodecyl ester 以 乙醇 为溶剂， 反应 2.0h， 生成 Acetic acid (1R,7R,12R)-7,12-dihydroxy-12-[(2R,5R)-5-((R)-1-hydroxy-tridecyl)-tetrahydro-furan-2-yl]-1-(6-methyl-3-oxo-2-phenyl-2,3-dihydro-pyridazin-4-ylmethyl)-dodecyl ester
  参考文献：
  名称：

  Two Epimeric Pairs of C-4-Acetyl Annonaceous Acetogenins fromGoniothalamus donnaiensis

  摘要：

  Further studies on the roots of Goniothalamus donnaiensis Finet et Gagnap (Annonaceae) led to the isolation of two pairs of Annonaceous acetogenins, donnaienin C (1) and 34-epi-donnaienin C (1′), donnaienin D (2) and 34-epi-donnaienin D (2′), containing a rare γ-hydroxymethyl-γ-lactone moiety and a C-4-acetoxy group. Their structures were elucidated by spectral data and chemical derivatization. Preliminary pharmacological tests showed that the mixture of donnaienin C(1) and 34-epi-donnaienin C (1′) inhibited human hepatoma (Bel) cell lines in vitro (IC50, 7.1 µg/ml).

  DOI：

  10.1055/s-2006-957452