4-[2-tert-Butoxycarbonyl-1-(6-hydroxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-benzoic acid methyl ester | 198011-12-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 4-[2-tert-Butoxycarbonyl-1-(6-hydroxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-benzoic acid methyl ester
• CAS: 198011-12-0
• 化学式: C₂₄H₂₇NO₆
• 分子量: 425.481
• InChiKey: QFIRVFHQFUVBSJ-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  4-[2-tert-Butoxycarbonyl-1-(6-hydroxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-benzoic acid methyl ester 在 potassium carbonate 作用下， 生成 4-{1-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-2-carboxy-ethyl}-benzoic acid methyl ester; compound with trifluoro-acetic acid
  参考文献：
  名称：

  Dihydroisoquinolone RGD mimics. Exploration of the aspartate isostere

  摘要：

  Disubstituted 3,4-dihydroisoquinolones that contain an ether-linked benzamidine at C-6 and a beta-substituted aspartate mimic at C-2 offer enhanced affinity for GPIIb-IIIa relative to the non-substituted isoquinolone propionate. Alkyl substituents afforded a 10-fold increase in intrinsic activity while aryl substituents yielded a 40-fold improvement. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)10014-2
• 作为产物：
  描述：

  4-[1-(6-Benzyloxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-2-tert-butoxycarbonyl-ethyl]-benzoic acid methyl ester 在 palladium on activated charcoal 氢气 作用下， 生成 4-[2-tert-Butoxycarbonyl-1-(6-hydroxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-benzoic acid methyl ester
  参考文献：
  名称：

  Dihydroisoquinolone RGD mimics. Exploration of the aspartate isostere

  摘要：

  Disubstituted 3,4-dihydroisoquinolones that contain an ether-linked benzamidine at C-6 and a beta-substituted aspartate mimic at C-2 offer enhanced affinity for GPIIb-IIIa relative to the non-substituted isoquinolone propionate. Alkyl substituents afforded a 10-fold increase in intrinsic activity while aryl substituents yielded a 40-fold improvement. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)10014-2