3-[(S)-2-(4-Methoxy-phenyl)-1-methylcarbamoyl-ethylsulfamoyl]-5-methyl-hexanoic acid tert-butyl ester | 750644-27-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[(S)-2-(4-Methoxy-phenyl)-1-methylcarbamoyl-ethylsulfamoyl]-5-methyl-hexanoic acid tert-butyl ester
• CAS: 750644-27-0
• 化学式: C₂₂H₃₆N₂O₆S
• 分子量: 456.604
• InChiKey: YWFSVZZTAZVHRU-GGYWPGCISA-N

反应信息

• 作为反应物：
  描述：

  3-[(S)-2-(4-Methoxy-phenyl)-1-methylcarbamoyl-ethylsulfamoyl]-5-methyl-hexanoic acid tert-butyl ester 在 三氟乙酸 作用下， 生成 3-[(S)-2-(4-Methoxy-phenyl)-1-methylcarbamoyl-ethylsulfamoyl]-5-methyl-hexanoic acid
  参考文献：
  名称：

  Amide surrogates of matrix metalloproteinase inhibitors: Urea and sulfonamide mimics

  摘要：

  A new method for the synthesis of succinyl sulfinyl chlorides was applied to the preparation of sulfonamide peptide mimics of MMP inhibitors. Sulfonamide mimics were determined to be active against MMPs and represent promising new leads for further optimization. Urea mimics were also prepared and found to be unstable and prone to hydantoin formation in protic media. (C) 1997 The DuPont Merck Pharmaceutical Company. Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00182-0
• 作为产物：
  描述：

  3-[(S)-2-(4-Methoxy-phenyl)-1-methylcarbamoyl-ethylsulfinamoyl]-5-methyl-hexanoic acid tert-butyl ester 在 ruthenium trichloride 、 sodium periodate 作用下， 以 四氯化碳 、 水 、 乙腈 为溶剂， 生成 3-[(S)-2-(4-Methoxy-phenyl)-1-methylcarbamoyl-ethylsulfamoyl]-5-methyl-hexanoic acid tert-butyl ester
  参考文献：
  名称：

  Amide surrogates of matrix metalloproteinase inhibitors: Urea and sulfonamide mimics

  摘要：

  A new method for the synthesis of succinyl sulfinyl chlorides was applied to the preparation of sulfonamide peptide mimics of MMP inhibitors. Sulfonamide mimics were determined to be active against MMPs and represent promising new leads for further optimization. Urea mimics were also prepared and found to be unstable and prone to hydantoin formation in protic media. (C) 1997 The DuPont Merck Pharmaceutical Company. Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00182-0