| 359417-39-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 359417-39-3
• 化学式: C₅₀H₇₂N₄O₈S₄
• 分子量: 985.408
• InChiKey: RPUSIMYZWKTVGK-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  、 alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydride 、 氢溴酸 、 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-Benzyl-N'-{3-[(3-benzylamino-propylamino)-methyl]-cyclohexylmethyl}-propane-1,3-diamine; compound with GENERIC INORGANIC NEUTRAL COMPONENT
  参考文献：
  名称：

  Novel Alkylpolyamine Analogues that Possess Both Antitrypanosomal and Antimicrosporidial Activity

  摘要：

  A novel series of alkyl- or aralkyl-substituted polyamine analogues was synthesized containing a 3-7-3 polyamine back bone. These analogues were evaluated in vitro, and in one case in vivo, for activity as antitrypanosomal agents, and for activity against opportunistic infection caused by Microsporidia. Compound 21 inhibits trypanosomal growth with an IC50 as low as 31 nM, while compound 24 shows promising activity in vitro against trypanosomes, and against Microsporidia in vitro and in vivo. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(01)00315-8
• 作为产物：
  描述：

  2,4,6-三甲基苯磺酰氯 、 N¹-{3-[(3-Amino-propylamino)-methyl]-cyclohexylmethyl}-propane-1,3-diamine 在 sodium hydroxide 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Novel Alkylpolyamine Analogues that Possess Both Antitrypanosomal and Antimicrosporidial Activity

  摘要：

  A novel series of alkyl- or aralkyl-substituted polyamine analogues was synthesized containing a 3-7-3 polyamine back bone. These analogues were evaluated in vitro, and in one case in vivo, for activity as antitrypanosomal agents, and for activity against opportunistic infection caused by Microsporidia. Compound 21 inhibits trypanosomal growth with an IC50 as low as 31 nM, while compound 24 shows promising activity in vitro against trypanosomes, and against Microsporidia in vitro and in vivo. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(01)00315-8