| 1228119-01-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 1228119-01-4
• 化学式: C₃₆H₆₂N₈O₉
• 分子量: 750.936
• InChiKey: WTQUOTFTKUFZAG-BTMUOSNYSA-N

反应信息

• 作为反应物：
  描述：

  在 水 、 三氟乙酸 作用下， 反应 20.0h， 以2.1 mg的产率得到
  参考文献：
  名称：

  Evaluation of retro-inverso modifications of HTLV-1 protease inhibitors containing a hydroxyethylamine isoster

  摘要：

  Effects of retro-inverso (RI) modifications of HTLV-1 protease inhibitors containing a hydroxyethylamine isoster backbone were clarified. Construction of the isoster backbone was achieved by a stereoselective aldol reaction. Four diastereomers with different configurations at the isoster hydroxyl site and the scissile site substituent were synthesized. Inhibitory activities of the new inhibitors suggest that partially modified RI inhibitors would interact with HTLV-1 protease in the same manner as the parent hydroxyethylamine inhibitor. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.02.019
• 作为产物：
  描述：

  (2R)-N-benzyl-2-[(2S,3S)-3-[[(2R,3R)-1-[[(2R)-1-[(2R)-2-[(2R)-2-carbamoylpyrrolidine-1-carbonyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]-2-hydroxy-5-methylhexyl]pyrrolidine-1-carboxamide 在 氢氟酸 、 苯甲醚 作用下， 反应 1.0h， 生成
  参考文献：
  名称：

  Evaluation of retro-inverso modifications of HTLV-1 protease inhibitors containing a hydroxyethylamine isoster

  摘要：

  Effects of retro-inverso (RI) modifications of HTLV-1 protease inhibitors containing a hydroxyethylamine isoster backbone were clarified. Construction of the isoster backbone was achieved by a stereoselective aldol reaction. Four diastereomers with different configurations at the isoster hydroxyl site and the scissile site substituent were synthesized. Inhibitory activities of the new inhibitors suggest that partially modified RI inhibitors would interact with HTLV-1 protease in the same manner as the parent hydroxyethylamine inhibitor. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.02.019