ethyl (2E)-2-(azidomethyl)-3-(2-chloro-5-methylpyridin-3-yl)prop-2-enoate | 1173104-86-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl (2E)-2-(azidomethyl)-3-(2-chloro-5-methylpyridin-3-yl)prop-2-enoate
• CAS: 1173104-86-3
• 化学式: C₁₂H₁₃ClN₄O₂
• 分子量: 280.714
• InChiKey: AMPVALNLLFITCV-BJMVGYQFSA-N

反应信息

• 作为反应物：
  描述：

  ethyl (2E)-2-(azidomethyl)-3-(2-chloro-5-methylpyridin-3-yl)prop-2-enoate 在 三苯基膦 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 15.0h， 生成 ethyl 6-methyl-1,8-naphthyridine-3-carboxylate
  参考文献：
  名称：

  由取代的2-氯烟碱醛的Baylis-Hillman加合物合成取代的1,8-萘啶-3-羧酸盐

  摘要：

  Abstractmagnified imageA series of substituted 1,8‐naphthyridine‐3‐carboxylates were synthesized for the first time from the Baylis–Hillman adducts obtained from 2‐chloronicotinaldehyde derivatives. Three methods were adopted to synthesize 1,8‐naphthyridine‐3‐carboxylates, of which the azide‐reduction route (Scheme 5) gave the best yields compared to the other attempted methods (Schemes 2 and 3).

  DOI：

  10.1002/hlca.200800352
• 作为产物：
  描述：

  2-[Acetoxy-(2-chloro-5-methyl-pyridin-3-yl)-methyl]-acrylic acid ethyl ester 在 三乙烯二胺 、 sodium azide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 0.08h， 以84%的产率得到ethyl (2E)-2-(azidomethyl)-3-(2-chloro-5-methylpyridin-3-yl)prop-2-enoate
  参考文献：
  名称：

  由取代的2-氯烟碱醛的Baylis-Hillman加合物合成取代的1,8-萘啶-3-羧酸盐

  摘要：

  Abstractmagnified imageA series of substituted 1,8‐naphthyridine‐3‐carboxylates were synthesized for the first time from the Baylis–Hillman adducts obtained from 2‐chloronicotinaldehyde derivatives. Three methods were adopted to synthesize 1,8‐naphthyridine‐3‐carboxylates, of which the azide‐reduction route (Scheme 5) gave the best yields compared to the other attempted methods (Schemes 2 and 3).

  DOI：

  10.1002/hlca.200800352