| 1416871-31-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• CAS: 1416871-31-2
• 化学式: C₁₅H₂₃ClN₂O₃SSi
• 分子量: 374.964
• InChiKey: GWBKOYQOKUTILA-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  phenylenediamine 在 三氯氧磷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2-[(2-Chloro-5-ethylsulfonylbenzimidazol-1-yl)methoxy]ethyl-trimethylsilane 、
  参考文献：
  名称：

  Identification of a novel benzimidazole derivative as a highly potent NPY Y5 receptor antagonist with an anti-obesity profile

  摘要：

  Optimization of HTS hit 1 for NPY Y5 receptor binding affinity, CYP450 inhibition, solubility and metabolic stability led to the identification of some orally available oxygen-linker derivatives for in vivo study. Among them, derivative 4i inhibited food intake induced by the NPY Y5 selective agonist, and chronic oral administration of 4i in DIO mice caused a dose-dependent reduction of body weight gain. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.11.005