aspartylglutamic acid trimethyl ester hydrochloride | 1443546-75-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: aspartylglutamic acid trimethyl ester hydrochloride
• CAS: 1443546-75-5
• 化学式: C₁₂H₂₀N₂O₇*ClH
• 分子量: 340.761
• InChiKey: LWECCGHQQBSVJX-WSZWBAFRSA-N

反应信息

• 作为反应物：
  描述：

  protoporphyrin IX 、 aspartylglutamic acid trimethyl ester hydrochloride 在 1-羟基苯并三唑 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 以87%的产率得到tetramethyl 2,2'-([2,7,12,18-tetramethyl-3,8-divinylporphyrin-13,17-diyl]bis{(1-oxopropane-3,1-diyl)imino[(2S)-4-methoxy-1,4-dioxobutane-2,1-diyl]imino})dipentanedioate
  参考文献：
  名称：

  A Practical Protocol for the Conjugation of Various Amino Acids to Protoporphyrin IX

  摘要：

  An effective and reliable method was developed for the synthesis of protoporphyrin IX-derived amides. The reaction of protoporphyrin IX with an amino acid [L-leucine, L-valine, L-lysine, L-aspartic acid (Asp), L-glutamic acid (Glu), glycine, or 6-aminohexanoic acid] or a short peptide (Asp-Glu) as an amine counterpart in the presence of O-(benzotriazol-1-yl)-N,N,N ',N '- etramethyluronium hexafluorophosphate and 1H-1,2,3-benzotriazol-1-ol gave the desired diamides in excellent yields.

  DOI：

  10.1055/s-0032-1318486