| 1419743-58-0

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• CAS: 1419743-58-0
• 化学式: C₆₆H₈₂N₁₅O₃₇P₅
• 分子量: 1832.32
• InChiKey: KVJKFRYTTQDWMU-VNPWRDKKSA-N

反应信息

• 作为产物：
  描述：

  在 谷胱甘肽 作用下， 以 aq. phosphate buffer 为溶剂， 反应 0.25h， 生成 、 、 、
  参考文献：
  名称：

  3′-Modified oligodeoxyribonucleotides for the study of 2-deoxyribose damage in DNA

  摘要：

  Well-defined substrates for the study of oxidative processes are important for the elucidation of the role of DNA damage in the etiology of diseases such as cancer. We have synthesized 3'-modified oligodeoxyribonucleotides (ODNs) using 5' -> 3' 'reverse' DNA synthesis for the study of 2-deoxyribose oxidative damage to DNA. The modified monomers designed for these studies all share a common feature, they lack the naturally occurring 3'-hydroxyl group found in 2-deoxyribonucleosides. Modified H-phosphonates containing 3'-phenyl selenides as well as saturated and unsaturated sugars were obtained and incorporated in ODNs. These ODNs were used to investigate the fate of C3'-dideoxyribonucleotide radicals in DNA. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.11.050