| 1284210-61-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• CAS: 1284210-61-2
• 化学式: C₁₇H₁₈N₂O₂S
• 分子量: 314.408
• InChiKey: YDFPKGRJGOOJSF-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 0.08h， 以68%的产率得到3-methyl-6-(thiophen-2-yl)imidazo[1,2-a]pyridine
  参考文献：
  名称：

  A Base Promoted Cyclization of N-Propargylaminopyridines. Synthesis of Imidazo[1,2-a]pyridine Derivatives

  摘要：

  A base promoted cyclization of the protected N-propargylaminopyridines was shown to be an efficient method for the preparation of imidazo[1,2-a] pyridine derivatives. The reactions were carried out with a small excess of base, at room temperature or slightly above producing the heterocyclic products in moderate to good yields. The stereoelectronic properties of substituents on the pyridine ring were shown to influence the cyclization process.

  DOI：

  10.1021/ol200508x