2-((1R,4S)-5,6,8-trimethoxy-4,7-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)ethanol | 1262943-85-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-((1R,4S)-5,6,8-trimethoxy-4,7-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)ethanol
• CAS: 1262943-85-0
• 化学式: C₁₇H₂₆O₄
• 分子量: 294.391
• InChiKey: QMEQKZOEGIZIAA-CMPLNLGQSA-N

反应信息

• 作为产物：
  描述：

  (1RS,4S)-5,6,8-trimethoxy-4,7-dimethyl-1-vinyl-1,2,3,4-tetrahydronaphthalene 在 硼烷四氢呋喃络合物 、 双氧水 、 sodium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 生成 2-((1S,4S)-5,6,8-trimethoxy-4,7-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)ethanol 、 2-((1R,4S)-5,6,8-trimethoxy-4,7-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)ethanol
  参考文献：
  名称：

  Toward the total synthesis of elisapterosin B: a Hg(OTf)2-promoted diastereoselective intramolecular Friedel–Crafts alkylation reaction

  摘要：

  As part of an approach to the synthesis of the antitubercular agent elisapterosin B, we prepared two different chiral, non-racemic olefinic substrates and examined their diastereoselective ring closure using mercury salts. The effort yielded potential precursors to elisapterosin B in good yield with good to excellent diastereocontrol. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.10.109