| 1415686-97-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• CAS: 1415686-97-3
• 化学式: C₂₅H₃₃NO₈
• 分子量: 475.539
• InChiKey: KRVCIEWOOGHMGB-WEBZPLDDSA-N

反应信息

• 作为反应物：
  描述：

  在 二氯二茂钛 、 偏二甲肼 、 锌 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 2.67h， 生成
  参考文献：
  名称：

  Synthesis of polycyclic ?-lactams. Evolution of tertiary radicals generated by Cp2TiCl from 1,5- and 1,6-epoxynitriles

  摘要：

  Radical cyclisation induced by Cp2TiCl of several 1,5- and 1,6-epoxynitriles derived from beta-lactams gave 3-oxo-4-methyl-4-hydroxymethylcarbapenams or 4-oxo-5-methylbenzocarbacephems. Apart from these polycyclic beta-lactams, the generated alkyl tertiary radicals also evolved to enamides through beta-fragmentation and reduction and the tertiary homobenzyl radicals gave a 3,4-trans-6-hydroxymonolactam by hydrogen transfer. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.11.015
• 作为产物：
  描述：

  (-)-1-[(1′,2′-dideoxy-3′,4′;5′,6′-di-O-isopropylene-1′-methoxycarbonylmethylene)-D-2′-glucosyl]-4β-[(1α,2α)-epoxy-1-methyl-2-phenylethyl]-3β-methoxy-2-azetidinone 在 臭氧 、 二甲基硫 作用下， 以 二氯甲烷 为溶剂， 反应 1.33h， 以94%的产率得到
  参考文献：
  名称：

  Synthesis of polycyclic ?-lactams. Evolution of tertiary radicals generated by Cp2TiCl from 1,5- and 1,6-epoxynitriles

  摘要：

  Radical cyclisation induced by Cp2TiCl of several 1,5- and 1,6-epoxynitriles derived from beta-lactams gave 3-oxo-4-methyl-4-hydroxymethylcarbapenams or 4-oxo-5-methylbenzocarbacephems. Apart from these polycyclic beta-lactams, the generated alkyl tertiary radicals also evolved to enamides through beta-fragmentation and reduction and the tertiary homobenzyl radicals gave a 3,4-trans-6-hydroxymonolactam by hydrogen transfer. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.11.015