9-oxa-3,7-diazabicyclo[3.3.1]nonane dihydrochloride | 90673-39-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 9-oxa-3,7-diazabicyclo[3.3.1]nonane dihydrochloride
• CAS: 90673-39-5
• 化学式: C₆H₁₂N₂O*2ClH
• 分子量: 201.096
• InChiKey: NMDCNEMWBGBDJC-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  9-oxa-3,7-diazabicyclo[3.3.1]nonane dihydrochloride 、 3-octylundecyl 8-bromooctanoate 在 N,N-二异丙基乙胺 、 potassium iodide 作用下， 以 乙腈 为溶剂， 以28.6 %的产率得到bis(3-octylundecyl) 8,8'-(9-oxa-3,7-diazabicyclo[3.3.1]nonane-3,7-diyl)dioctanoate
  参考文献：
  名称：

  [EN] NOVEL LIPIDS FOR DELIVERY OF NUCLEIC ACID SEGMENTS
  [FR] NOUVEAUX LIPIDES POUR L'ADMINISTRATION DE SEGMENTS D'ACIDE NUCLÉIQUE

  摘要：

  Disclosed herein are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein X1, Y1, X2, Y2, a, b, c, d, e and f are as defined herein. Also disclosed are lipid nanoparticles comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a plurality of lipid nanoparticles comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof and a nucleic acid segment; as well as methods for delivering a nucleic acid segment comprising administering a plurality of lipid nanoparticles comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and a nucleic acid segment.

  公开号：

  WO2023073534A1
• 作为产物：
  描述：

  9-氧杂-3,7-二氮杂双环[3.3.1]壬烷-3-羧酸叔丁酯盐酸盐 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 以97 %的产率得到9-oxa-3,7-diazabicyclo[3.3.1]nonane dihydrochloride
  参考文献：
  名称：

  [EN] NOVEL LIPIDS FOR DELIVERY OF NUCLEIC ACID SEGMENTS
  [FR] NOUVEAUX LIPIDES POUR L'ADMINISTRATION DE SEGMENTS D'ACIDE NUCLÉIQUE

  摘要：

  Disclosed herein are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein X1, Y1, X2, Y2, a, b, c, d, e and f are as defined herein. Also disclosed are lipid nanoparticles comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a plurality of lipid nanoparticles comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof and a nucleic acid segment; as well as methods for delivering a nucleic acid segment comprising administering a plurality of lipid nanoparticles comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and a nucleic acid segment.

  公开号：

  WO2023073534A1