| 644968-74-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 644968-74-1
• 化学式: C₁₉₀H₃₆₄N₁₄O₄₅
• 分子量: 3565.05
• InChiKey: QWHJKAXVDUDNPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  27.28
• 重原子数：
  249.0
• 可旋转键数：
  152.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  586.15
• 氢给体数：
  0.0
• 氢受体数：
  59.0

反应信息

• 作为反应物：
  描述：

  在 乙酰氯 作用下， 以 二氯甲烷 为溶剂， 生成 3-[3-[3-[3-[3-[3-[3-[Bis[3-[3-[bis[3-[3-[bis(2-carboxyethyl)amino]propoxy]propyl]amino]propoxy]propyl]amino]propoxy]propyl-[3-[3-[bis[3-[3-[bis(2-carboxyethyl)amino]propoxy]propyl]amino]propoxy]propyl]amino]propoxy]propyl-[3-[3-[bis(2-carboxyethyl)amino]propoxy]propyl]amino]propoxy]propyl-(2-carboxyethyl)amino]propanoic acid
  参考文献：
  名称：

  Poly propyl ether imine (PETIM) dendrimer: A novel non-toxic dendrimer for sustained drug delivery

  摘要：

  In the present study, an attempt was made to study the acute and sub-acute toxicity profile of G3-COOH Poly (propyl ether imine) [PETIM] dendrimer and its use as a carrier for sustained delivery of model drug ketoprofen. Drug-dendrimer complex was prepared and characterized by FTIR, solubility and in vitro drug release study. PETIM dendrimer was found to have significantly less toxicity in A541 cells compared to Poly amido amine (PAMAM) dendrimer. Further, acute and 28 days sub-acute toxicity measurement in mice showed no mortality, hematological, biochemical or histopathological changes up to 80 mg/kg dose of PETIM dendrimer. The results of study demonstrated that G3-COOH PETIM dendrimer can be used as a safe and efficient vehicle for sustained drug delivery. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.08.006
• 作为产物：
  描述：

  丙烯酸叔丁酯 、 Bis-[3-(3-{bis-[3-(3-amino-propoxy)-propyl]-amino}-propoxy)-propyl]-[3-(3-{bis-[3-(3-{bis-[3-(3-amino-propoxy)-propyl]-amino}-propoxy)-propyl]-amino}-propoxy)-propyl]-amine 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Poly propyl ether imine (PETIM) dendrimer: A novel non-toxic dendrimer for sustained drug delivery

  摘要：

  In the present study, an attempt was made to study the acute and sub-acute toxicity profile of G3-COOH Poly (propyl ether imine) [PETIM] dendrimer and its use as a carrier for sustained delivery of model drug ketoprofen. Drug-dendrimer complex was prepared and characterized by FTIR, solubility and in vitro drug release study. PETIM dendrimer was found to have significantly less toxicity in A541 cells compared to Poly amido amine (PAMAM) dendrimer. Further, acute and 28 days sub-acute toxicity measurement in mice showed no mortality, hematological, biochemical or histopathological changes up to 80 mg/kg dose of PETIM dendrimer. The results of study demonstrated that G3-COOH PETIM dendrimer can be used as a safe and efficient vehicle for sustained drug delivery. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.08.006