| 1203458-34-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• CAS: 1203458-34-7
• 化学式: C₂₄H₄₃N₃O₄Si₂
• 分子量: 493.794
• InChiKey: MWPOEJDOYAWMPJ-MISYRCLQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.15
• 重原子数：
  33.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  88.6
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  在 triethylamine tris(hydrogen fluoride) 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以71%的产率得到4-amino-1-<(1R,2R,3R)-2,3-dihydroxy-4-hydroxymethyl-4-cyclopenten-1-yl>-2(1H)-pyrimidinone
  参考文献：
  名称：

  A Convergent Approach for the Synthesis of Ara-Neplanocin a Analogues Under Subzero Microwave Assisted Conditions

  摘要：

  A convergent strategy for the synthesis of ara-neplanocin A analogues has been developed. Microwave assisted Mitsunobu reaction proved to be an essential tool both for the 2'-beta-hydroxy inversion and for the coupling reaction with the heterocyclic bases. The exploitation of the present approach allowed generating a family of ara-neplanocins which biological potential is still unexplored.

  DOI：

  10.1080/15257770903044143
• 作为产物：
  描述：

  在 ammonium hydroxide 作用下， 以 乙腈 为溶剂， 反应 5.0h， 以182 g的产率得到
  参考文献：
  名称：

  A Convergent Approach for the Synthesis of Ara-Neplanocin a Analogues Under Subzero Microwave Assisted Conditions

  摘要：

  A convergent strategy for the synthesis of ara-neplanocin A analogues has been developed. Microwave assisted Mitsunobu reaction proved to be an essential tool both for the 2'-beta-hydroxy inversion and for the coupling reaction with the heterocyclic bases. The exploitation of the present approach allowed generating a family of ara-neplanocins which biological potential is still unexplored.

  DOI：

  10.1080/15257770903044143