| 1219600-16-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1219600-16-4
• 化学式: C₂₄H₃₁BO₇
• 分子量: 442.317
• InChiKey: VJRPRNZMDKPZBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.73
• 重原子数：
  32.0
• 可旋转键数：
  8.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  94.45
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  在 盐酸 、 4-二甲氨基吡啶 、 sodium periodate 、 甲酸 、 三乙胺 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 2-[[2-[(4-Boronophenyl)methoxy]-3-[[carboxymethyl(methyl)carbamoyl]oxymethyl]-5-ethoxycarbonylphenyl]methoxycarbonyl-methylamino]acetic acid
  参考文献：
  名称：

  Chemically Reactive Supramolecular Hydrogel Coupled with a Signal Amplification System for Enhanced Analyte Sensitivity

  摘要：

  Multicomponent supramolecular hydrogels are constructed for sensitive, naked-eye detection of small-molecule biomarkers. A dendritic self-immolative molecule and the corresponding enzyme as a signal amplification system were stably embedded in a hydrogen peroxide (H2O2)-responsive supramolecular hydrogel (BPmoc-F-3), together with other enzymes. The nanostructure and mechanical strength of the hybrid BPmoc-F-3 gel were not substantially diminished by incorporation of these multiple components in the absence of target biomarkers, but could be destroyed by addition of the biomarker through the multiple enzymatic and chemical cascade reactions operating in combination within the gel matrix. The sensitivity to biomarkers such as H2O2, glucose, and uric acid, detected by gel-sol transition, was significantly enhanced by the signal amplification system. An array chip consisting of these multicomponent hydrogels enabled the detection of the level of hyperuricemia disease in human plasma samples.

  DOI：

  10.1021/ja5131534
• 作为产物：
  描述：

  在 p-TsOH 作用下， 以 methanol 为溶剂， 以82%的产率得到
  参考文献：
  名称：

  双组分树枝状链反应：实验和理论

  摘要：

  基于信号放大机制的新分析诊断技术可以显着提高检测各种分析物的灵敏度。我们开发了一种新方法，通过双组分树突链反应实现诊断信号的指数放大。链式反应产生了感兴趣的分析物，从而启动了额外的诊断循环。该系统专为检测过氧化氢而设计，产生的诊断信号强度明显高于经典探针。此外，还开发了一种模拟单组分和双组分反应的分解动力学的数学模型，并证明其与观察到的实验数据具有良好的相关性。

  DOI：

  10.1021/ja910839n

文献信息

• Exponential diagnostic signal amplification via dendritic chain reaction: the dendritic effect of a self-immolative amplifier component
  作者：Naama Karton-Lifshin、Doron Shabat

  DOI：10.1039/c1nj20486f

  日期：——

  Signal amplification techniques are commonly used to boost diagnostic signals. We have recently developed a new approach for exponential signal amplification obtained through a distinctive dendritic chain reaction. Here we report evaluation of the effect of the self-immolative dendritic amplifier component on the signal amplification. Four dendrons with various numbers of end-units were evaluated for the ability to produce exponential signal amplification through self-immolative disassembly pathways. The dendron composed of a first-generation platform with three end-units exhibited the best characteristics with rapid disassembly rate and good stability under aqueous conditions. This study demonstrates the efficiency of molecules based on dendritic structures.

  信号放大技术通常用于增强诊断信号。我们最近开发了一种通过独特的树枝状链反应获得的指数信号放大的新方法。在此，我们报告了自去活性树枝状放大器组件对信号放大影响的评估。我们评估了四种不同末端单元数目的树枝状结构在自去活性解体路径中产生指数信号放大的能力。由第一代平台和三个末端单元组成的树枝状结构表现出了最佳特性，具有快速解体速率和良好的水相稳定性。本研究展示了基于树枝状结构的分子的效率。