Boc-Ser(Ac)-Pro-OH | 7801-83-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Ser(Ac)-Pro-OH
• CAS: 7801-83-4
• 化学式: C₁₅H₂₄N₂O₇
• 分子量: 344.365
• InChiKey: QYJJJHYJJFKODD-QWRGUYRKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.52
• 重原子数：
  24.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  122.24
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  Boc-Ser(Ac)-Pro-OH 、 在 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以88%的产率得到[(2S)-3-[(2S)-2-[[(3S,4S)-1-cyano-4-methyl-2-oxo-1-(triphenyl-lambda5-phosphanylidene)hexan-3-yl]carbamoyl]pyrrolidin-1-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-oxopropyl] acetate
  参考文献：
  名称：

  Preparation and biological evaluation of key fragments and open analogs of scleritodermin A

  摘要：

  The synthesis of key fragments of scleritodermin A. their assembly, and their biological evaluation as cytotoxic and anthelmintic were performed. Highlights of the synthetic route include formation of the alpha-ketoamide linkage and use of stereocontrolled reactions. Open analogs of this natural product were obtained using a convergent strategy. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.05.040
• 作为产物：
  描述：

  Boc-Ser(Ac)-Pro-OBn 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 以100%的产率得到Boc-Ser(Ac)-Pro-OH
  参考文献：
  名称：

  Preparation and biological evaluation of key fragments and open analogs of scleritodermin A

  摘要：

  The synthesis of key fragments of scleritodermin A. their assembly, and their biological evaluation as cytotoxic and anthelmintic were performed. Highlights of the synthetic route include formation of the alpha-ketoamide linkage and use of stereocontrolled reactions. Open analogs of this natural product were obtained using a convergent strategy. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.05.040