[(1S,2R,1'R,2'R,1''R,2''R,1'''R,2'''R,1''''R,2''''R,1'''''R,2'''''R,1''''''S,2''''''R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2';1',2'';1'',1''';2''',1'''';2'''',1''''';2''''',1'''''']septicyclopropan-2''''''-yl]-methanol | 335248-31-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: [(1S,2R,1'R,2'R,1''R,2''R,1'''R,2'''R,1''''R,2''''R,1'''''R,2'''''R,1''''''S,2''''''R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2';1',2'';1'',1''';2''',1'''';2'''',1''''';2''''',1'''''']septicyclopropan-2''''''-yl]-methanol
• CAS: 335248-31-2
• 化学式: C₂₉H₄₈O₂Si
• 分子量: 456.784
• InChiKey: SFVCPFGIUHVSHK-OGQTYVFXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.45
• 重原子数：
  32.0
• 可旋转键数：
  10.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.46
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  [(1S,2R,1'R,2'R,1''R,2''R,1'''R,2'''R,1''''R,2''''R,1'''''R,2'''''R,1''''''S,2''''''R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2';1',2'';1'',1''';2''',1'''';2'''',1''''';2''''',1'''''']septicyclopropan-2''''''-yl]-methanol 在 4-二甲氨基吡啶 、 四丁基氟化铵 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 1.0h， 生成 Phthalic acid mono-((1S,2R,1'R,2'R,1''R,2''R,1'''R,2'''R,1''''R,2''''R,1'''''R,2'''''R,1''''''S,2''''''R)-2''''''-hydroxymethyl-[1,2';1',2'';1'',1''';2''',1'''';2'''',1''''';2''''',1'''''']septicyclopropan-2-ylmethyl) ester
  参考文献：
  名称：

  Multiple Asymmetric Cyclopropanation: Synthesis and X-Ray Crystallographic Studies of a Prototype Coronane and all anti-trans-1,15-Quinquecyclopropanedimethanol

  摘要：

  DOI：

  10.1055/s-1998-5930
• 作为产物：
  描述：

  叔丁基二甲基氯硅烷 、 all syn-trans-1,15-quinquecyclopropanedimethanol 在 咪唑 作用下， 以 二氯甲烷 为溶剂， 以52%的产率得到[(1S,2R,1'R,2'R,1''R,2''R,1'''R,2'''R,1''''R,2''''R,1'''''R,2'''''R,1''''''S,2''''''R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2';1',2'';1'',1''';2''',1'''';2'''',1''''';2''''',1'''''']septicyclopropan-2''''''-yl]-methanol
  参考文献：
  名称：

  Synthesis and Characterization of Coronanes:  Multicyclopropane-Fused Macrocyclic Arrays

  摘要：

  Stepwise macrocyclization of the all syn-trans-1,15-quinquecyclopropanedimethanol (4) with iso- and terephthaloyl chlorides and 4,4'-methanediyl-dibenzoic acid (28) gave the corresponding coronanes 22, 23, and 32. The same protocol was used with all syn-trans-1,21-septecyclopropanedimethanol (5) and 2,3-naphthalenedicarboxylic acid to obtain the macrolide 27. Direct macrocyclization of diol 4 and 1,10-phenanthroline-2,9-dicarbonyl chloride (33) and 2,2'-bipyridine-4,4'-dicarbonyl chloride (35) gave the coronanes 34 and 36, respectively. Ring closing metathesis (RCM) of the diene 42 using Cl-2(Cy3P)(2)Ru=CHPh (48) (Grubbs's catalyst) gave the macrocyclic lactone 45. The structures of coronanes 22, 23, 32, 34, 36, and 45 were confirmed by X-ray crystallographic studies which showed the cyclopropyl chain to adopt very differing conformations throughout the series. Several of the macrocycles have significant free pathways through their ring centers, and in the case of compound 34 there is a water molecule hydrogen bonded within the ring. This latter compound has the potential to act as a chiral ligand to metal centers.

  DOI：

  10.1021/jo001167d