16-mercaptohexadecanamide | 124536-79-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 16-mercaptohexadecanamide
• 英文别名: 16-sulfanylhexadecanamide
• CAS: 124536-79-4
• 化学式: C₁₆H₃₃NOS
• 分子量: 287.51
• InChiKey: PIJCUJXBPYCINA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  19
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  44.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  16-Mercapto-hexadecanoyl chloride 在 ammonium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 生成 16-mercaptohexadecanamide
  参考文献：
  名称：

  有机表面微观润湿的基础研究。1. 自洽系列多功能有机单层的形成和结构表征

  摘要：

  一系列末端取代的烷基硫醇 X(CH 2 ) 15 SH（X=CH 3 、CH 2 OH、CO 2 H、CO 2 CH 3 和 CONH 2 ）的单层已经通过从溶液吸附到蒸发的金基板。该结构已通过红外 (IR) 光谱、X 射线光电子能谱 (XPS)、椭偏仪和程序升温脱附 (TPD) 进行表征。IR 数据显示单层薄膜是密集堆积的晶体状结构，具有全反式构象的烷基链，链轴的平均倾斜角与表面法线成 28-40° 的范围，并且大约有 55° 的扭曲。链轴远离 CCC 平面垂直于表面平面的配置

  DOI：

  10.1021/ja00158a012

文献信息

• [EN] HETEROCYCLIC-DITHIOL CLICK CHEMISTRY<br/>[FR] CHIMIE CLICK DE DITHIOL HÉTÉROCYCLIQUE
  申请人：UNIV NORTHEASTERN

  公开号：WO2019014311A1

  公开（公告）日：2019-01-17

  Disclosed are polymers, methods of making polymers, and compositions, focused on cross-linking heterocycles comprising a moiety of Formula I with thiols and thiolates.

  本发明涉及含有公式I中的基团的杂环交联聚合物、制备杂环交联聚合物的方法以及组合物，其中所述杂环通过与硫醇和硫醇酸盐进行交联。
• Templated monolayer polymerization and replication
  申请人：——

  公开号：US20040076757A1

  公开（公告）日：2004-04-22

  A self-replicating monolayer system employing polymerization of monomers or nanoparticle ensembles on a defined template provides a method for synthesis of two-dimensional single molecule polymers. Systems of self-replicating monolayers may be used as templates for the growth of inorganic colloids. A preferred embodiment is a SAM-based replication, wherein an initial monolayer is patterned and used as a template for self-assembly of a second monolayer by molecular recognition. Once the second monolayer has formed, it is polymerized in place and the two monolayers are separated to form a replicate. Both monolayers may then function as templates for monolayer assemblies. A generic self-replicating monomer unit suitable for use in one embodiment comprises a polymerizable moiety attached by methylene repeats to a recognition element and an ending unit that will not interfere with the chosen recognition chemistry. The recognition element is self-complementary, unless a set of two replicating monomers with compatible cross-linking chemistry is employed. In a two-component replication system utilizing two different kinds of recognition chemistries, the initial template undergoes replication cycles, while maintaining the two-dimensional segregation of the two types of monomers. During subsequent replications, the component domains experience little or no mixing, allowing the two-component, patterned assembly to be exponentially replicated. After replication, selective mineralization and/or electroless plating may produce a two-dimensional inorganic sheet having patterned domains within it.

  一种利用单体或纳米颗粒集合物在定义的模板上聚合的自复制单分子层系统，提供了一种合成二维单分子聚合物的方法。自复制单分子层系统可用作无机胶体生长的模板。首选实施方式是基于SAM的复制，其中初始单分子层被图案化并用作通过分子识别自组装第二个单分子层的模板。一旦第二个单分子层形成，它就在原位聚合，然后将两个单分子层分离以形成复制品。两个单分子层都可以作为单分子层组装的模板。适用于一种实施方式的通用自复制单体单元包括通过亚甲基重复连接到识别元素的可聚合基团和不会干扰所选择的识别化学反应的终端单元。识别元素是自互补的，除非采用具有兼容交联化学的两个复制单体的集合。在利用两种不同类型的识别化学反应的两组分复制系统中，初始模板经历复制周期，同时维持两种单体的二维分离。在随后的复制过程中，组分域经历很少或没有混合，允许指数级复制两个组分的图案组装。复制后，选择性矿化和/或电无镀可产生具有其中图案域的二维无机片。
• Templated Monolayer Polymerization and Replication
  申请人：Jacobson Joseph M.

  公开号：US20090326269A1

  公开（公告）日：2009-12-31

  A self-replicating monolayer system employing polymerization of monomers or nanoparticle ensembles on a defined template provides a method for synthesis of two-dimensional single molecule polymers. Systems of self-replicating monolayers are used as templates for growth of inorganic colloids. A preferred embodiment employs SAM-based replication, wherein an initial monolayer is patterned and used as a template for self-assembly of a second monolayer by molecular recognition. The second monolayer is polymerized in place and the monolayers are separated to form a replicate. Both may then function as templates for monolayer assemblies. A generic self-replicating monomer unit comprises a polymerizable moiety attached by methylene repeats to a recognition element and an ending unit that will not interfere with the chosen recognition chemistry. The recognition element is self-complementary, unless a set of two replicating monomers with compatible cross-linking chemistry is employed. In a two-component replication system utilizing two different kinds of recognition chemistries, the initial template undergoes replication cycles, while maintaining two-dimensional segregation of the two types of monomers. During subsequent replications, the component domains experience little or no mixing, allowing the two-component, patterned assembly to be exponentially replicated. After replication, selective mineralization and/or electroless plating may produce a two-dimensional inorganic sheet having patterned domains within it.

  一种利用单分子聚合物化或纳米颗粒集合在定义的模板上的自复制单分子层系统，提供了一种合成二维单分子聚合物的方法。自复制单分子层系统被用作无机胶体的生长模板。首选实施方式采用基于SAM的复制，其中初始单分子层被图案化并用作分子识别的模板，以自组装第二单分子层。第二单分子层在原位聚合，单分子层被分离以形成复制品。两者都可以作为单分子层组装的模板。一般的自复制单体单元包括一个可聚合的基团，通过亚甲基重复连接到一个识别元素和一个不会干扰所选择的识别化学反应的终端单元。识别元素是自补的，除非使用具有兼容交联化学的两个复制单体的集合。在利用两种不同的识别化学反应的两组分复制系统中，初始模板经历复制周期，同时保持两种单体的二维分离。在随后的复制过程中，组分区域经历很少或没有混合，允许两组分图案组装呈指数复制。复制后，选择性矿化和/或电化学镀层可产生具有图案域的二维无机片。
• SYNTHESIS OF FUNCTIONALIZABLE OR FUNCTIONALIZED POLY(3,4-ETHYLENEDIOXYTHIPHENE)-BASED POLYMERS AND MONOMERS THEREFOR
  申请人：University of Pittsburgh - Of the Commonwealth System of Higher Education

  公开号：US20200181163A1

  公开（公告）日：2020-06-11

  A method of forming a compound having the formula (I′): (I′) includes the reaction: (II′) in the presence of a base, wherein X is a halo atom selected from the group consisting of Cl, Br and I.

  一种制备化合物(I')的方法：(I')的化合物包括反应：(II')在碱的存在下进行，其中X是从群组选择的卤原子，所述群组包括Cl、Br和I。
• Covalent treatment with thiols of keratin-containing materials
  申请人：Living Proof, Inc.

  公开号：US10993903B2

  公开（公告）日：2021-05-04

  Disclosed are methods of preparing thiol keratin-containing materials, comprising applying a mixture comprising one or more thiol compounds and a catalyst. Methods of preparing cross-linked keratin-containing materials by applying a mixture comprising one or more thiol compounds and an oxidizing agent are also disclosed. Methods of grafting monomeric and polymeric materials on keratin-containing materials to provide a covalent coating on keratin-containing materials are disclosed. A mixture comprising one or more thiol compounds is applied to the keratin-containing material sample. The keratin-containing material sample then comprises a plurality of free thiol groups. A monomer is optionally applied to the keratin-containing material sample to form a plurality of covalent bonds between the free thiol groups and the monomers. The disclosed grafting methods can be carried out with or without catalyst.

  本发明公开了制备含硫醇角蛋白材料的方法，包括使用由一种或多种硫醇化合物和催化剂组成的混合物。还公开了通过使用由一种或多种硫醇化合物和氧化剂组成的混合物制备交联含角蛋白材料的方法。公开了在含角蛋白材料上接枝单体和聚合物材料以在含角蛋白材料上提供共价涂层的方法。将包含一种或多种硫醇化合物的混合物涂抹在含角蛋白材料样品上。这样，含角蛋白材料样品就含有多个游离硫醇基团。可选择将单体应用于含角蛋白材料样品，以在游离硫醇基团和单体之间形成多个共价键。所公开的接枝方法可在使用或不使用催化剂的情况下进行。