oxiran-2-ylmethyl N-butylcarbamate | 1234357-95-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: oxiran-2-ylmethyl N-butylcarbamate
• CAS: 1234357-95-9
• 化学式: C₈H₁₅NO₃
• mdl: MFCD24388518
• 分子量: 173.212
• InChiKey: BHVFOAHTKFQKBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  50.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  oxiran-2-ylmethyl N-butylcarbamate 在 sodium azide 、 氯化铵 作用下， 以 甲醇 、 水 为溶剂， 反应 24.0h， 以81%的产率得到
  参考文献：
  名称：

  Library of 1,4-Disubstituted 1,2,3-Triazole Analogs of Oxazolidinone RNA-Binding Agents

  摘要：

  The design and synthesis of small molecules that target RNA is immensely important in antibacterial therapy. We had previously reported on the RNA binding of a series of 4,5-disubstituted 2-oxazolidinones that bind to a highly conserved bulge region of bacterial RNA. This biological target T box antitermination system, which is found mainly in Gram-positive bacteria, regulates the expression of several amino acid related genes. In an effort to amplify our library, we have prepared a library of I,4-disubstituted 1,2,3-triazole analogs that entails an isosteric replacement of the oxazolidinone nucleus. The synthesis of the new analogs was enhanced via copper(I) catalysis of an azide and alkyne cycloaddition reaction. A total of 108 1,4-disubstituted 1,2,3-triazole compounds have been prepared. All compounds were evaluated as RNA binding agents.

  DOI：

  10.1021/cc100029y
• 作为产物：
  描述：

  N-Butyl-carbamidsaeure-allylester 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成 oxiran-2-ylmethyl N-butylcarbamate
  参考文献：
  名称：

  Library of 1,4-Disubstituted 1,2,3-Triazole Analogs of Oxazolidinone RNA-Binding Agents

  摘要：

  The design and synthesis of small molecules that target RNA is immensely important in antibacterial therapy. We had previously reported on the RNA binding of a series of 4,5-disubstituted 2-oxazolidinones that bind to a highly conserved bulge region of bacterial RNA. This biological target T box antitermination system, which is found mainly in Gram-positive bacteria, regulates the expression of several amino acid related genes. In an effort to amplify our library, we have prepared a library of I,4-disubstituted 1,2,3-triazole analogs that entails an isosteric replacement of the oxazolidinone nucleus. The synthesis of the new analogs was enhanced via copper(I) catalysis of an azide and alkyne cycloaddition reaction. A total of 108 1,4-disubstituted 1,2,3-triazole compounds have been prepared. All compounds were evaluated as RNA binding agents.

  DOI：

  10.1021/cc100029y

文献信息

• HARDCOAT FILM AND ARTICLE AND IMAGE DISPLAY DEVICE HAVING HARDCOAT FILM
  申请人：FUJIFILM Corporation

  公开号：US20220056228A1

  公开（公告）日：2022-02-24

  A hardcoat film includes: a substrate; and a hardcoat layer, in which the hardcoat film satisfies the following Formulas (i) and (ii), (i) E′ (0.4)HC ×d HC ≥8,000 MPa·μm, (ii) E′ (4)HC ×d HC ≤4,000 MPa·μm, E′ (0.4)HC is an elastic modulus of the hardcoat layer obtained in a case where an elongation rate is 0.4%, E′ (4)HC is an elastic modulus of the hardcoat layer obtained in a case where an elongation rate is 4%, and d HC is a film thickness of the hardcoat layer.
• Library of 1,4-Disubstituted 1,2,3-Triazole Analogs of Oxazolidinone RNA-Binding Agents
  作者：George Acquaah-Harrison、Shu Zhou、Jennifer V. Hines、Stephen C. Bergmeier

  DOI：10.1021/cc100029y

  日期：2010.7.12

  The design and synthesis of small molecules that target RNA is immensely important in antibacterial therapy. We had previously reported on the RNA binding of a series of 4,5-disubstituted 2-oxazolidinones that bind to a highly conserved bulge region of bacterial RNA. This biological target T box antitermination system, which is found mainly in Gram-positive bacteria, regulates the expression of several amino acid related genes. In an effort to amplify our library, we have prepared a library of I,4-disubstituted 1,2,3-triazole analogs that entails an isosteric replacement of the oxazolidinone nucleus. The synthesis of the new analogs was enhanced via copper(I) catalysis of an azide and alkyne cycloaddition reaction. A total of 108 1,4-disubstituted 1,2,3-triazole compounds have been prepared. All compounds were evaluated as RNA binding agents.