(2-{2-[2-(2-t-butoxycarbonylaminoethoxy)ethoxycarbonylamino]ethoxy}ethoxycarbonylamino)acetic acid ethyl ester | 1174636-24-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2-{2-[2-(2-t-butoxycarbonylaminoethoxy)ethoxycarbonylamino]ethoxy}ethoxycarbonylamino)acetic acid ethyl ester
• 英文别名: (2-{2-[2-(2-t-Butoxycarbonylaminoethoxy)ethoxycarbonylamino]ethoxy}ethoxycarbonylamino)-acetic acid ethyl ester；ethyl 2-[2-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxycarbonylamino]ethoxy]ethoxycarbonylamino]acetate
• CAS: 1174636-24-8
• 化学式: C₁₉H₃₅N₃O₁₀
• 分子量: 465.501
• InChiKey: XSJVHAIMMWOITL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  32
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  160
• 氢给体数：
  3
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  (2-{2-[2-(2-t-butoxycarbonylaminoethoxy)ethoxycarbonylamino]ethoxy}ethoxycarbonylamino)acetic acid ethyl ester 在 盐酸 、 lithium hydroxide 作用下， 以 四氢呋喃 为溶剂， 生成 (2-{2-[2-(2-t-butoxycarbonylaminoethoxy)ethoxycarbonylamino]ethoxy}ethoxycarbonylamino)acetic acid
  参考文献：
  名称：

  US2011/14715

  摘要：

  公开号：

文献信息

• Synthesis of peptide nucleic acids conjugated with amino acids and their application
  申请人：Lee Hyunil

  公开号：US08450469B2

  公开（公告）日：2013-05-28

  This invention relates to a peptide nucleic acid (PNA) oligomer which is conjugated with one or more linear-type amino acid containing a plurality of alkyleneglycols and to a synthesis method thereof. In addition, this invention related to a linear amino acid spacer in a device for detection for detecting a target gene using the PNA oligomers which is fixed on a surface of a functionalized solid support. The linear amino acid spacer contains a plurality of alkyleneglycols and maintains enough space between the solid support and PNA oligomer in the device in order to prevent the interference of the interaction between the PNA oligomer and a target gene. Furthermore, this invention relates to a PNA array, a PNA chip and a gene diagnosis kit whereof sensitivity and specificity are improved by being manufactured with the PNA conjugated with the amino acid spacer.

  本发明涉及一种与一种或多种含有多个烷基二醇的线性氨基酸共轭的肽核酸（PNA）寡聚体及其合成方法。此外，本发明涉及一种线性氨基酸间隔物，其用于检测装置中，用于检测靶基因的PNA寡聚体固定在功能化固体支持物的表面上。线性氨基酸间隔物包含多个烷基二醇，并在装置中保持固体支持物和PNA寡聚体之间足够的间隔，以防止PNA寡聚体与靶基因之间的相互作用干扰。此外，本发明涉及一种PNA阵列、PNA芯片和基因诊断试剂盒，其灵敏度和特异性得到提高，因为它们是用与氨基酸间隔物共轭的PNA制造的。
• Synthesis of Peptide Nucleic Acids Conjugated with Amino Acids and Their Application
  申请人：Lee Hyunil

  公开号：US20110014715A1

  公开（公告）日：2011-01-20

  This invention relates to a peptide nucleic acid (PNA) oligomer which is conjugated with one or more linear-type amino acid containing a plurality of alkyleneglycols and to a synthesis method thereof. In addition, this invention related to a linear amino acid spacer in a device for detection for detecting a target gene using the PNA oligomers which is fixed on a surface of a functionalized solid support. The linear amino acid spacer contains a plurality of alkyleneglycols and maintains enough space between the solid support and PNA oligomer in the device in order to prevent the interference of the interaction between the PNA oligomer and a target gene. Furthermore, this invention relates to a PNA array, a PNA chip and a gene diagnosis kit whereof sensitivity and specificity are improved by being manufactured with the PNA conjugated with the amino acid spacer.

  本发明涉及一种肽核酸（PNA）寡聚物，其与一种或多种含有多个烷基乙二醇的线性型氨基酸偶联，并涉及其合成方法。此外，本发明涉及一种线性氨基酸间隔物，在用固定在功能化固体支撑物表面的PNA寡聚物检测目标基因的装置中使用。该线性氨基酸间隔物包含多个烷基乙二醇，并保持固体支撑物与PNA寡聚物之间的足够间隔，以防止PNA寡聚物与目标基因之间的相互作用干扰。此外，本发明涉及一种PNA阵列、PNA芯片和基因诊断试剂盒，其灵敏度和特异性通过使用与氨基酸间隔物偶联的PNA制备而得到提高。
• US8450469B2
  申请人：——

  公开号：US8450469B2

  公开（公告）日：2013-05-28
• [EN] SYNTHESIS OF PEPTIDE NUCLEIC ACIDS CONJUGATED WITH AMINO ACIDS AND THEIR APPLICATION<br/>[FR] SYSTHÈSE D'ACIDES NUCLÉIQUES PEPTIDIQUES CONJUGUÉS À DES ACIDES AMINÉS ET LEUR APPLICATION
  申请人：——

  公开号：WO2009093821A2

  公开（公告）日：2009-07-30

  본 발명은 다수의 알킬렌글리콜(alkyleneglycol)을 갖는 긴 선형 사슬의 아미노산이 하나 이상 결합된 펩티드 핵산(peptide nucleic acid, 이하 'PNA'라 함) 올리고머와 이의 합성법에 대한 것이다. 또한, 본 발명은 기능화된 고형지지체의 표면에 고정된 PNA 올리고머을 이용하여 타겟 유전자를 검출하는 장치에서 고형지지체와 PNA 올리고머 사이의 충분한 거리를 유지하여 PNA 올리고머와 타겟 유전자와의 상호 작용이 방해받지 않도록 공간을 확보할 수 있게 하는 다수의 알킬렌글리콜을 갖는 긴 선형 사슬의 아미노산 스페이서에 대한 것이다. 또한, 본 발명은 상기 아미노산 스페이서가 결합된 PNA를 이용하여 제작된 민감도와 특이성이 개선된 PNA 어레이, PNA 칩 및 유전자 진단용 키트에 관한 것이다.