1-bromo-N-[(1-formyl)propyl]-cyclopropane-1-carboxamide | 198759-44-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-bromo-N-[(1-formyl)propyl]-cyclopropane-1-carboxamide
• 英文别名: 1-bromo-N-(1-oxobutan-2-yl)cyclopropane-1-carboxamide
• CAS: 198759-44-3
• 化学式: C₈H₁₂BrNO₂
• 分子量: 234.093
• InChiKey: NYXQOWQKFQQAJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(1-Bromocyclopropyl)-4-ethyloxazole 、 1-bromo-N-[(1-formyl)ethyl]cyclopropyl-1-carboxamide 生成 1-bromo-N-[(1-formyl)propyl]-cyclopropane-1-carboxamide
  参考文献：
  名称：

  NEW VITAMIN D DERIVATIVES WITH CARBO-OR HETEROCYCLIC SUBSTITUENTS AT C-25, A PROCESS FOR THEIR PRODUCTION, INTERMEDIATE PRODUCTS AND THEIR USE FOR PRODUCING MEDICAMENTS

  摘要：

  该发明涉及一般式（I）的新维生素D衍生物，以及它们的生产方法、用于生产药物的用途，以及用于该过程中的中间产物。

  公开号：

  US20020049344A1

文献信息

• New vitamin D derivatives with carbo-or heterocyclic substituents at C-25, a process for their production, intermediate products and their use for producing medicaments
  申请人：Steinmeyer Andreas

  公开号：US20050080058A1

  公开（公告）日：2005-04-14

  Compounds of Formula I, wherein Y 1 , Y 2 , R 1 -R 6 , Q and Z are as defined herein, are vitamin D derivatives. These compounds are useful for, e.g., the treatment hyperprolifierative diseases of the skin, tumor diseases and precancerous stages, auto-immune diseases, rejection reactions in the case of autologous, allogenic or xenogenic transplants, AIDS, atopic skin conditions, secondary hyperparathyroidism, renal osteodystrophia, senile and postmenopausal osteoporosis, diabetes mellitus type II, degenerative diseases of the peripheral and central nervous system, hypercalcemias, granulomatous diseases, paraneoplastic hypercalcemias, hypercalcemias in hyperparathyroidism, hirsutism, ateriosclerosis, and/or inflammatory diseases.

  式I的化合物，其中Y1，Y2，R1-R6，Q和Z如本文所定义，是维生素D衍生物。这些化合物可用于治疗皮肤增生性疾病、肿瘤疾病和癌前期、自身免疫疾病、自体、同种异体或异种移植的排斥反应、艾滋病、特应性皮肤病、继发性甲状旁腺功能亢进症、肾性骨营养不良、老年和绝经后骨质疏松症、2型糖尿病、周围和中枢神经系统退行性疾病、高钙血症、肉芽肿性疾病、副肿瘤性高钙血症、甲状旁腺功能亢进症的高钙血症、多毛症、动脉硬化和/或炎症性疾病的治疗。
• Vitamin D derivatives with carbo- or heterocyclic substituents at C-25, a process for their production, intermediate products and their use for producing medicaments
  申请人：Schering Aktiengellschaft

  公开号：US06600058B1

  公开（公告）日：2003-07-29

  The invention concerns new vitamin D derivatives of general formula (I) a process for their production, their use for production of medicaments, and intermediate products used in the process.

  本发明涉及一种新的维生素D衍生物，其一般式为（I），以及其制备方法，用于制备药物的用途，以及用于该过程中使用的中间产物。
• Vitamin D derivatives with carbo- or heterocyclic substituents at C-25, process for their production, intermediate products and use for the production of pharmaceutical agents
  申请人：Schering Aktiengesellschaft

  公开号：US06613920B1

  公开（公告）日：2003-09-02

  The invention relates to vitamin D derivatives of formula (I), processes for the production thereof and uses thereof: wherein Y1, Y2, R1—R6, Q and Z are as defined herein.

  该发明涉及公式（I）的维生素D衍生物，其生产过程和用途：其中Y1，Y2，R1-R6，Q和Z的定义如本文所述。
• Vitamin D derivatives with carbo-or heterocyclic substituents at C-25, a process for their production, intermediate products and their use for producing medicaments
  申请人：Schering Aktiengesellschaft

  公开号：US07211680B2

  公开（公告）日：2007-05-01

  Compounds of Formula I, wherein Y1, Y2, R1–R6, Q and Z are as defined herein, are vitamin D derivatives. These compounds are useful for, e.g., the treatment hyperprolifierative diseases of the skin, tumor diseases and precancerous stages, auto-immune diseases, rejection reactions in the case of autologous, allogenic or xenogenic transplants, AIDS, atopic skin conditions, secondary hyperparathyroidism, renal osteodystrophia, senile and postmenopausal osteoporosis, diabetes mellitus type II, degenerative diseases of the peripheral and central nervous system, hypercalcemias, granulomatous diseases, paraneoplastic hypercalcemias, hypercalcemias in hyperparathyroidism, hirsutism, ateriosclerosis, and/or inflammatory diseases.

  化合物I的公式中，其中Y1、Y2、R1-R6、Q和Z的定义如本文所述，是维生素D衍生物。这些化合物可用于治疗皮肤的增生性疾病、肿瘤疾病和癌前期、自身免疫性疾病、自体、同种异体或异种移植的排斥反应、艾滋病、特应性皮肤病、继发性甲状旁腺功能亢进症、肾性骨营养不良、老年性和绝经后骨质疏松症、2型糖尿病、周围和中枢神经系统的退行性疾病、高钙血症、肉芽肿性疾病、原发性恶性肿瘤引起的高钙血症、甲状旁腺功能亢进症引起的高钙血症、多毛症、动脉硬化和/或炎症性疾病的治疗。
• NEUE VITAMIN-D-DERIVATE MIT CARBO- ODER HETEROCYCLISCHEN SUBSTITUENTEN AN C-25, VERFAHREN ZU IHRER HERSTELLUNG, ZWISCHENPRODUKTE UND DIE VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN
  申请人：Schering Aktiengesellschaft

  公开号：EP0900198B1

  公开（公告）日：2003-03-12