Bisindolylmaleimide III hydrochloride | 683775-59-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: Bisindolylmaleimide III hydrochloride
• 英文别名: 3-[1-(3-aminopropyl)indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione;hydrochloride
• CAS: 683775-59-9
• 化学式: C₂₃H₂₀N₄O₂*ClH
• 分子量: 420.898
• InChiKey: NXIKRXJEVAWDAX-UHFFFAOYSA-N

物化性质

• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  3.46
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  92.9
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  tert-butyl N-[3-[3-[4-(1H-indol-3-yl)-2,5-dioxopyrrol-3-yl]indol-1-yl]propyl]carbamate 在 盐酸 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 生成 Bisindolylmaleimide III hydrochloride
  参考文献：
  名称：

  Aryl–indolyl maleimides as inhibitors of CaMKIIδ. Part 1: SAR of the aryl region

  摘要：

  A family of aryl-substituted maleimides was prepared and studied for their activity against calmodulin dependant kinase. Inhibitory activities against the enzyme ranged from 34 nM to > 20 mu M and were dependant upon both the nature of the aryl group and the hydrogen bond donating potential of the maleimide ring. Key interactions with the kinase ATP site and hinge region were found to be consistent with homology modeling predictions. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.02.059

文献信息

• COMBINATION THERAPIES FOR MALARIA
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20160151379A1

  公开（公告）日：2016-06-02

  The present disclosure provides methods for treating or preventing malaria by administration of a protein kinase inhibitor and optionally one or both of a further protein kinase inhibitor and an antimalarial drug to a mammalian subject infected with or at risk of exposure to Plasmodium sp. In some aspects, the therapeutic and prophylactic regimens of the present disclosure are effective in reducing parasite development in mosquitoes feeding on recipients of the regimens. Additionally, the present disclosure provides methods for screening candidate antimalarial agents.
• METHODS AND COMPOSITIONS FOR IMPROVING HOMING OF CELLS INCLUDING MESENCHYMAL STEM CELLS
  申请人：SANOFI

  公开号：US20170216360A1

  公开（公告）日：2017-08-03

  The disclosure relates to methods and compositions for improving homing of cells including mesenchymal stem cells (MSCs). Compositions include compounds described herein as capable of inducing expression by MSCs of cell surface homing ligand molecules such as CD1 la, promoting increased firm adhesion by MSCs in an in vitro shear flow assay, increasing binding to an adhesion molecule such as E-selectin or ICAM-1, and/or demonstrating anti-inflammatory activity upon in vivo systemic administration in cell therapy using human MSCs. Also described are screening methods to identify small molecule compounds for improving a homing function of MSCs.
• [EN] COMBINATION THERAPIES FOR MALARIA<br/>[FR] POLYTHÉRAPIES CONTRE LA MALARIA
  申请人：UNIV CALIFORNIA

  公开号：WO2015006752A1

  公开（公告）日：2015-01-15

  The present disclosure provides methods for treating or preventing malaria by administration of a protein kinase inhibitor and optionally one or both of a further protein kinase inhibitor and an antimalarial drug to a mammalian subject infected with or at risk of exposure to Plasmodium sp. In some aspects, the therapeutic and prophylactic regimens of the present disclosure are effective in reducing parasite development in mosquitos feeding on recipients of the regimens. Additionally, the present disclosure provides methods for screening candidate antimalarial agents.
• [EN] THERAPIES FOR DISEASES CAUSED BY ARTHROPOD-BORNE PARASITES<br/>[FR] THÉRAPIES POUR DES MALADIES CAUSÉES PAR DES PARASITES PORTÉS PAR DES ARTHROPODES
  申请人：UNIV CALIFORNIA

  公开号：WO2015006753A2

  公开（公告）日：2015-01-15

  The present disclosure provides methods for treating or preventing diseases caused by arthropod-borne parasites by administration of a protein kinase inhibitor to a mammalian subject infected with or at risk of exposure to an arthropod-borne parasite. In some aspects, the therapeutic and prophylactic regimens of the present disclosure are effective in reducing parasite development in arthropods feeding on recipients of the regimens. Additionally, the present disclosure provides methods for screening candidate anti-parasitic agents.
• [EN] METHODS AND COMPOSITIONS FOR IMPROVING HOMING OF CELLS INCLUDING MESENCHYMAL STEM CELLS<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR AMÉLIORER LE GUIDAGE DE CELLULES SOUCHES MÉSENCHYMATEUSES
  申请人：SANOFI SA

  公开号：WO2015112602A1

  公开（公告）日：2015-07-30

  The disclosure relates to methods and compositions for improving homing of cells including mesenchymal stem cells (MSCs). Compositions include compounds described herein as capable of inducing expression by MSCs of cell surface homing ligand molecules such as CD1 la, promoting increased firm adhesion by MSCs in an in vitro shear flow assay, increasing binding to an adhesion molecule such as E-selectin or ICAM-1, and/or demonstrating anti-inflammatory activity upon in vivo systemic administration in cell therapy using human MSCs. Also described are screening methods to identify small molecule compounds for improving a homing function of MSCs.