2-[[(4R,5S)-5-[(3aR,4R,6R,7aR)-2,2-dimethyl-6-[(2R)-oxiran-2-yl]-4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-4-yl]-2,2-dimethyl-1,3-dioxolan-4-yl]methoxymethoxy]ethyl-trimethylsilane | 927887-86-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧吡喃
• 英文名称: 2-[[(4R,5S)-5-[(3aR,4R,6R,7aR)-2,2-dimethyl-6-[(2R)-oxiran-2-yl]-4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-4-yl]-2,2-dimethyl-1,3-dioxolan-4-yl]methoxymethoxy]ethyl-trimethylsilane
• CAS: 927887-86-3
• 化学式: C₂₂H₄₀O₈Si
• 分子量: 460.64
• InChiKey: MPHLYKVVHHRXBW-AIFSHUDHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.91
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  77.1
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2-[[(4R,5S)-5-[(3aR,4R,6R,7aR)-2,2-dimethyl-6-[(2R)-oxiran-2-yl]-4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-4-yl]-2,2-dimethyl-1,3-dioxolan-4-yl]methoxymethoxy]ethyl-trimethylsilane 、 三甲基碘化锍 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以87%的产率得到
  参考文献：
  名称：

  Development of an Access Route to the C31−C52 Central Core of Amphidinol 3

  摘要：

  An asymmetric synthesis of the heavily oxygenated inner sector of amphidinol 3 constituted of C31-C52 is described. The successful pathway highlights construction of the pair of identical tetrahydropyran subunits from a common intermediate.

  DOI：

  10.1021/ol062875+
• 作为产物：
  描述：

  、 2,2-二甲氧基丙烷 在 4-甲基苯磺酸吡啶 作用下， 以89%的产率得到2-[[(4R,5S)-5-[(3aR,4R,6R,7aR)-2,2-dimethyl-6-[(2R)-oxiran-2-yl]-4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-4-yl]-2,2-dimethyl-1,3-dioxolan-4-yl]methoxymethoxy]ethyl-trimethylsilane
  参考文献：
  名称：

  Development of an Access Route to the C31−C52 Central Core of Amphidinol 3

  摘要：

  An asymmetric synthesis of the heavily oxygenated inner sector of amphidinol 3 constituted of C31-C52 is described. The successful pathway highlights construction of the pair of identical tetrahydropyran subunits from a common intermediate.

  DOI：

  10.1021/ol062875+

文献信息

• Development of an Access Route to the C31−C52 Central Core of Amphidinol 3
  作者：Matthew W. Bedore、Shuh-Kuen Chang、Leo A. Paquette

  DOI：10.1021/ol062875+

  日期：2007.2.1

  An asymmetric synthesis of the heavily oxygenated inner sector of amphidinol 3 constituted of C31-C52 is described. The successful pathway highlights construction of the pair of identical tetrahydropyran subunits from a common intermediate.