N,N'-bis<(tert-butyloxy)carbonyl>-3-(aminooxy)-2-(mesyloxy)propanamine | 139526-87-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: N,N'-bis<(tert-butyloxy)carbonyl>-3-(aminooxy)-2-(mesyloxy)propanamine
• 英文别名: [1-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-[(2-methylpropan-2-yl)oxycarbonylamino]oxypropan-2-yl] methanesulfonate
• CAS: 139526-87-7
• 化学式: C₁₄H₂₈N₂O₈S
• 分子量: 384.451
• InChiKey: JAUDCGZWONJWKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  25
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  138
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  N,N'-bis<(tert-butyloxy)carbonyl>-3-(aminooxy)-2-(mesyloxy)propanamine 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以79.2%的产率得到Methanesulfonic acid 1-aminomethyl-2-aminooxy-ethyl ester; hydrochloride
  参考文献：
  名称：

  2-Substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity

  摘要：

  1-Amino-3-(aminooxy)-2-propanol (6a) has been synthesized and found to inhibit rat liver ornithine decarboxylase (ODC) with an IC50 in the nanomolar range. Compound 6a served as a basis for the design of new enzyme inhibitors, which led to the identification of 3-(aminooxy)-2-fluoropropanamine (15) as a new powerful enzyme blocker. Compound 15 inhibited ODC at 3 times lower concentrations than 6a and 3-(aminooxy)propanamine (APA), and it was superior to APA as an antiproliferative agent in inhibiting the growth of human T24 bladder carcinoma cells in vitro.

  DOI：

  10.1021/jm00086a003
• 作为产物：
  描述：

  甲基磺酰氯 、 N,N'-bis<(tert-butyloxy)carbonyl>-1-amino-3-(aminooxy)-2-propanol 在 吡啶 作用下， 反应 16.0h， 以98%的产率得到N,N'-bis<(tert-butyloxy)carbonyl>-3-(aminooxy)-2-(mesyloxy)propanamine
  参考文献：
  名称：

  2-Substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity

  摘要：

  1-Amino-3-(aminooxy)-2-propanol (6a) has been synthesized and found to inhibit rat liver ornithine decarboxylase (ODC) with an IC50 in the nanomolar range. Compound 6a served as a basis for the design of new enzyme inhibitors, which led to the identification of 3-(aminooxy)-2-fluoropropanamine (15) as a new powerful enzyme blocker. Compound 15 inhibited ODC at 3 times lower concentrations than 6a and 3-(aminooxy)propanamine (APA), and it was superior to APA as an antiproliferative agent in inhibiting the growth of human T24 bladder carcinoma cells in vitro.

  DOI：

  10.1021/jm00086a003

文献信息

• Method for utilizing triethylaluminum to prepare an alumoxane support for an active metallocene catalyst
  申请人：EXXON CHEMICAL PATENTS INC.

  公开号：EP0368644A1

  公开（公告）日：1990-05-16

  This invention relates to a process for preparing a supported metallocene alumoxane catalyst for use in the polymerization of olefins. The invention particularly relates to the use of silica gel containing from about 6 to about 20 per cent by weight adsorbed water as the catalyst support material. It has been found that such silica gel may be safely added to a solution, of trialkylaluminum to form by direct reaction with the adsorbed water content of the silica gel catalyst support material the majority of the alumoxane component requirement of the catalyst system. An alkylalumoxane coated silica gel is formed to which a trimethylaluminum treated metallocene may be added and the resulting material dried to free-flowing powder. The dry free flowing powder may then be used as a supported metallocene alumoxane catalyst complex for gas phase or liquid phase polymerization of olefins. The supported catalyst produced by such procedure has an activity at least comparable to a catalyst of similar composition which is produced exclusively with trimethylaluminum as the alumoxane forming aluminum alkyl.

  本发明涉及一种用于烯烃聚合的支撑茂金属铝氧烷催化剂的制备工艺。本发明特别涉及使用硅胶作为催化剂载体材料，硅胶吸附水的重量百分比为 6%至 20%。研究发现，这种硅胶可以安全地加入到三烷基铝溶液中，通过与硅胶催化剂载体材料中的吸附水直接反应，形成催化剂体系所需的大部分铝氧烷组分。烷基铝氧烷涂层硅胶形成后，可向其中添加经三甲基铝处理的茂金属，并将所得材料干燥成自由流动的粉末。干燥后的自由流动粉末可用作支撑茂金属铝氧烷催化剂复合物，用于烯烃的气相或液相聚合。通过这种方法制得的支撑催化剂的活性至少可与完全以三甲基铝作为铝氧烷形成铝烷基的类似成分的催化剂相媲美。
• Substituierte Oxadiaminobutane
  申请人：CIBA-GEIGY AG

  公开号：EP0369944A1

  公开（公告）日：1990-05-23

  Verbindungen der Formel I worin R₁, R₂, R₃ und X die in der Beschreibung angegebenen Bedeutungen haben, weisen wertvolle pharmazeutische Eigenschaften auf und sind insbesondere gegen Tumoren wirksam. Sie werden in an sich bekannter Weise hergestellt.

  式 I 的化合物 其中 R₁、R₂、R₃ 和 X 的含义在描述中给出。它们以已知的方式生产。
• 2-Substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity
  作者：Jaroslav Stanek、Joerg Frei、Helmut Mett、Peter Schneider、Urs Regenass

  DOI：10.1021/jm00086a003

  日期：1992.4

  1-Amino-3-(aminooxy)-2-propanol (6a) has been synthesized and found to inhibit rat liver ornithine decarboxylase (ODC) with an IC50 in the nanomolar range. Compound 6a served as a basis for the design of new enzyme inhibitors, which led to the identification of 3-(aminooxy)-2-fluoropropanamine (15) as a new powerful enzyme blocker. Compound 15 inhibited ODC at 3 times lower concentrations than 6a and 3-(aminooxy)propanamine (APA), and it was superior to APA as an antiproliferative agent in inhibiting the growth of human T24 bladder carcinoma cells in vitro.