6-ethyl-3-hydroxy-2-methyl-4-pyrone | 131524-06-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 6-ethyl-3-hydroxy-2-methyl-4-pyrone
• 英文别名: ethylmaltol；6-ethyl-3-hydroxy-2-methylpyran-4-one
• CAS: 131524-06-6
• 化学式: C₈H₁₀O₃
• 分子量: 154.166
• InChiKey: MOVXRZYRDPFMQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-aminomorphine 、 6-ethyl-3-hydroxy-2-methyl-4-pyrone 以 甲醇 、 水 为溶剂， 生成 N-(1-Morphinyl)-2-Ethyl-3-Hydroxy-4-Pyridinone
  参考文献：
  名称：

  N-substituted 3-hydroxy-4-pyridinones and pharmaceuticals containing thereof

  摘要：

  N-取代的3-羟基-4-吡啶酮和金属螯合物，制备N-取代的3-羟基-4-吡啶酮和金属螯合物的方法，以及含有新的N-取代的3-羟基-4-吡啶酮和/或其金属螯合物的制药组合物。使用N-取代的3-羟基-4-吡啶酮及其金属螯合物作为治疗疾病的药物，如寄生虫和病毒感染、与炎症和感染有关的疾病、以及由细胞增殖或胶原形成介导的疾病。

  公开号：

  US20030170174A1
• 作为产物：
  描述：

  1-(5-ethyl-2-furyl)ethanol 在 氢溴酸 、 溴 、 sodium acetate 作用下， 生成 6-ethyl-3-hydroxy-2-methyl-4-pyrone
  参考文献：
  名称：

  Arnarp, Jan; Bielawski, Jacek; Dahlin, Britt-Marie, Acta Chemica Scandinavica, 1990, vol. 44, # 7, p. 916 - 926

  摘要：

  DOI：

文献信息

• [EN] SUBSTITUTED BUTANOL DERIVATIVES AND THEIR USE AS FRAGRANCE AND FLAVOR MATERIALS<br/>[FR] DÉRIVÉS SUBSTITUÉS DU BUTANOL, ET LEUR UTILISATION EN TANT QUE PARFUMS ET ARÔMES
  申请人：TAKASAGO PERFUMERY CO LTD

  公开号：WO2010002386A1

  公开（公告）日：2010-01-07

  The present invention is related to substituted butanol derivatives of the formula; wherein R is an unsubstituted or substituted C1-6 straight chain alkyl, an unsubstituted or substituted C3-6 branched chain alkyl an uosubstituted or substituted C3-6 straight chain alkenyl, an unsubstituted or substituted Cu= branched chain alkenyl, an unsubstituted or substituted C3-6 cycioalkyl, an unsubstituted or substituted C1-6 alkoxy, nitiile, halo, amino, an unsubstituted or substituted C1-6 alkyiamino, w. unsubstituted or substituted C1-6 dialkyfaraino, carboxy-C1-6 alkyiamino, carboxy-C1-6 di alkyl amino, an unsubstituted or substituted acetoxy, carboxy, an unsubstituted or substituted carboxyethyi, an unsubstituted or substituted C1-6 aikylcarbonyi, an unsubstituted or substituted C1-6 aikylcarboxy, ao unsubsiituted or substituted C1-6 alkylthio, an unsubstituted or substituted C1-6 alkyloxy. carboxamido, an unsubstituted or substituted C1-6 alkylcarboxarøido or an unsubstituted or substituted C1-6 dia'lkylcarboxamido. Such compounds are useful in flavor or flavor compositions.

  本发明涉及以下结构的取代丁醇衍生物；其中R是未取代或取代的C1-6直链烷基，未取代或取代的C3-6支链烷基，未取代或取代的C3-6直链烯基，未取代或取代的C3-6支链烯基，未取代或取代的C3-6环烷基，未取代或取代的C1-6烷氧基，硝基，卤素，氨基，未取代或取代的C1-6烷基氨基，未取代或取代的C1-6二烷基氨基，羧基-C1-6烷基氨基，羧基-C1-6二烷基氨基，未取代或取代的乙酰氧基，羧基，未取代或取代的羧乙基，未取代或取代的C1-6烷基羰基，未取代或取代的C1-6烷基羧基，未取代或取代的C1-6烷基硫基，未取代或取代的C1-6烷氧基，羧胺基，未取代或取代的C1-6烷基羧酰胺或未取代或取代的C1-6二烷基羧酰胺。这些化合物在香料或香料组合物中有用。
• [EN] HEMI-AMINAL ETHERS AND THIOETHERS OF N-ALKENYL CYCLIC COMPOUNDS<br/>[FR] ÉTHERS ET THIOÉTHERS HÉMIAMINAUX DE COMPOSÉS CYCLIQUES N-ALCÉNYLIQUES
  申请人：ISP INVESTMENTS INC

  公开号：WO2014116560A1

  公开（公告）日：2014-07-31

  Described herein are hemi-aminal ethers and thioethers of N-alkenyl cyclic compounds that may be produced through a reaction comprising: (A) at least one first reactant represented by a structure (I), wherein X is a functionalized or unfunctionalized C1-C5 alkylene group optionally having one or more heteroatoms, and each R1, R2, and R3 is independently selected from the group consisting of hydrogen and functionalized and unfunctionalized alkyl groups optionally having one or more heteroatoms, and (B) at least one second reactant having at least one hydroxyl moiety or thiol moiety. The hemi-aminal ethers and thioethers of N-alkenyl cyclic compounds may comprise a polymerizable moiety, in which case they may be left as-is or used to create homopolymers or non-homopolymers, or they may not comprise a polymerizable moiety. A wide variety of formulations may be created using the hemi-aminal ethers and thioethers of N-alkenyl cyclic compounds, including personal care, oilfield, and construction formulations.

  本文描述了可以通过反应制备的N-烯基环状化合物的半胺醚和硫醚，所述反应包括：（A）至少一个由结构（I）表示的第一反应物，其中X是一个官能化或非官能化的C1-C5烷基烯烃基团，可选地具有一个或多个杂原子，每个R1、R2和R3分别独立地选自氢和官能化和非官能化的烷基基团，可选地具有一个或多个杂原子；和（B）至少一个具有至少一个羟基基团或硫醇基团的第二反应物。N-烯基环状化合物的半胺醚和硫醚可能包括一个可聚合的基团，此时它们可以保持原样或用于制备同聚物或非同聚物，或者它们可能不包括可聚合的基团。可以使用N-烯基环状化合物的半胺醚和硫醚制备各种配方，包括个人护理、油田和建筑配方。
• [EN] AMINO ACID DERIVATIVES AND THEIR USE AS FLAVOR MODIFIERS<br/>[FR] DÉRIVÉS D'ACIDES AMINÉS ET LEUR UTILISATION EN TANT QUE MODIFICATEURS DE GOÛT
  申请人：FIRMENICH & CIE

  公开号：WO2021209345A1

  公开（公告）日：2021-10-21

  The present invention provides derivatives of glutamine of formula (I) and derivatives of arginine of formula (II), and the use of such compounds as flavor modifiers. The invention further provides the use of such derivatives of glutamine and arginine to enhance the salty and umami taste of ingestible compositions as ingestible compositions that include such derivatives of glutamine and arginine and bulking agents.

  本发明提供了公式(I)的谷氨酰衍生物和公式(II)的精氮酸衍生物，以及将这些化合物用作风味调节剂的用途。该发明进一步提供了利用这些谷氨酰和精氮酸衍生物增强可摄入组合物的咸味和鲜味的用途，作为包含这些谷氨酰和精氮酸衍生物以及增稠剂的可摄入组合物。
• Anilino-pyrimidine phenyl and benzothiophene analogs
  申请人：Hu Yongbo

  公开号：US20070244140A1

  公开（公告）日：2007-10-18

  The present invention relates to compounds of formula III: wherein R 2 , R 3 , R 5 and R 6 are as defined herein.

  本发明涉及以下式III的化合物： 其中R2、R3、R5和R6如本文所定义。
• Methods for the production of peptide derivatives
  申请人：Tovi Avi

  公开号：US20060276626A1

  公开（公告）日：2006-12-07

  The invention relates to methods for the preparation of peptides which are a C-terminal amide derivatives by a combination of solid-phase synthesis and post assembly solution phase synthesis. The peptides which are a C-terminal amide derivatives are further converted to peptide acetates. The invention also relates to pure peptide acetates and to protected peptide precursors.

  这项发明涉及一种通过固相合成和后组装溶液相合成相结合的方法制备C-末端酰胺衍生物的肽。这些C-末端酰胺衍生物的肽进一步转化为肽醋酸酯。该发明还涉及纯肽醋酸酯和受保护的肽前体。