cryptoporic acid A | 113592-87-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cryptoporic acid A
• 英文别名: (3S,4R)-4-[[(1S,4aS,8aS)-5,5,8a-trimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]methoxy]-5-methoxy-3-methoxycarbonyl-5-oxopentanoic acid
• CAS: 113592-87-3
• 化学式: C₂₃H₃₆O₇
• 分子量: 424.535
• InChiKey: OCKYURAITHEIMQ-UGECPWBJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  30
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  99.1
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  cryptoporic acid A 在 臭氧 、 溶剂黄146 、 锌 作用下， 以 乙醚 为溶剂， 反应 2.5h， 生成 (2R,3S)-3-Methoxycarbonyl-2-((1S,4aS,8aS)-5,5,8a-trimethyl-2-oxo-decahydro-naphthalen-1-ylmethoxy)-pentanedioic acid dimethyl ester
  参考文献：
  名称：

  Cryptoporic Acids AG，​​来自真菌 Cryptoporus volvatus 的异柠檬酸的 drimane 型倍半萜醚

  摘要：

  摘要 从真菌 Cryptoporous volvatus 中分离出了 7 种具有异柠檬酸基团的新型苦味 drimane 型倍半萜类化合物，称为隐孔酸 (CA) AG，并通过化学转化、NMR 光谱数据和 X 射线晶体学分析相结合建立了它们的绝对立体结构。隐孔酸强烈抑制豚鼠腹腔巨噬细胞和兔多形核白细胞释放超氧阴离子自由基。CA-E 显示抗肿瘤促进活性，而 CA-D 略微增强肿瘤促进和蛋白激酶 C 活性。CA 还在 200 ppm 时抑制第二胚芽鞘的伸长和稻壳中水稻的发芽。

  DOI：

  10.1016/0031-9422(92)90042-o

文献信息

• FERMENTATION PRODUCT OF CYPTOPORUS VOLVATUS AND ITS PREPARATION METHOD AND USE
  申请人：Hangzhou Tsbio Science & Technology Co., Ltd.

  公开号：EP1422292A1

  公开（公告）日：2004-05-26

  This invention provides a preparation method of fermentation product of Cryptoporus volvatus (Peck) Schear and its clinical use, the said Cryptoporus volvatus (Peck) Schear is cultured on culture medium for fluid fermentation or solid fermentation to obtain mycelium of Cryptoporus volvatus (Peck) Schear, culture supernatant fluid and various metabolins, the culture medium of which contains glucose, maltose, yeast powder, peptone, inorganic salts and vitamins.The said fermentation product can be made into kinds of drug forms to prevent and treat irritability diseases, for example, bronchus asthma, allergic rhinitis, allergic gastroenteritis or ophthalmopathy which is caused by pollen, acarid, mildew or dust. Moreover, it can be used for preventing and treating cough.

  本发明提供了一种隐翅虫发酵产物的制备方法及其临床用途，将所述隐翅虫在培养基上进行流体发酵或固体发酵，得到隐翅虫菌丝体、培养上清液和各种代谢产物，所述培养基中含有葡萄糖、麦芽糖、酵母粉、蛋白胨、无机盐和维生素。上述发酵产物可制成各种药剂，用于预防和治疗由花粉、螨虫、霉菌或灰尘引起的过敏性疾病，如支气管哮喘、过敏性鼻炎、过敏性胃肠炎或眼病。此外，它还可用于预防和治疗咳嗽。
• Fermentation product of cyptoporous volvatus and its preparation method and use
  申请人：——

  公开号：US20040241184A1

  公开（公告）日：2004-12-02

  This invention provides a preparation method of fermentation product of Cryptoporus volvatus (Peck) Schear and its clinical use, the said Cryptoporus volvatus (Peck) Schear is cultured on culture medium for fluid fermentation or solid fermentation to obtain mycelium of Cryptoporus volvatus (Peck) Schear, culture supernatant fluid and various metabolins, the culture medium of which contains glucose, maltose, yeast powder, peptone, inorganic salts and vitamins. The said fermentation product can be made into kinds of drug forms to prevent and treat irritability diseases, for example, bronchus asthma, allergic rhinitis, allergic gastroenteritis or ophthalmopathy which is caused by pollen, acarid, mildew or dust. Moreover, it can be used for preventing and treating cough.

  本发明提供了一种发酵产品的制备方法。 隐翅虫 (Peck) Schear 的发酵产物的制备方法及其临床应用。 隐翅虫 (Peck)Schear在培养基上进行流体发酵或固体发酵，以获得隐翅虫的菌丝体。 隐翅虫 (Peck) Schear）的菌丝体、培养上清液和各种代谢物，其中培养基含有葡萄糖、麦芽糖、酵母粉、蛋白胨、无机盐和维生素。上述发酵产物可制成各种药剂，用于预防和治疗由花粉、螨虫、霉菌或灰尘引起的过敏性疾病，如支气管哮喘、过敏性鼻炎、过敏性胃肠炎或眼病。此外，它还可用于预防和治疗咳嗽。
• Biologically Active Substances of Japanese Inedible Mushrooms
  作者：Yoshinori Asakawa、Toshihiro Hashimoto

  DOI：10.3987/rev-97-sr(n)6

  日期：——
• HASHIMOTO, TOSHIHIRO;TORI, MOTOO;MIZUNO, YASUO;ASAKAWA, YOSHINORI, TETRAHEDRON LETT., 28,(1987) N 50, 6303-6304
  作者：HASHIMOTO, TOSHIHIRO、TORI, MOTOO、MIZUNO, YASUO、ASAKAWA, YOSHINORI

  DOI：——

  日期：——
• SESQUITERPENE COMPOUNDS
  申请人：TOAGOSEI CO., LTD.

  公开号：EP0810198B1

  公开（公告）日：2000-08-30