2,6-Dihydroxy-4-(1,1,2,2-tetrafluoro-2-methoxycarbonyl-ethoxy)-benzoic acid methyl ester | 131043-22-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,6-Dihydroxy-4-(1,1,2,2-tetrafluoro-2-methoxycarbonyl-ethoxy)-benzoic acid methyl ester
• 英文别名: methyl 2,6-dihydroxy-4-(1,1,2,2-tetrafluoro-3-methoxy-3-oxopropoxy)benzoate
• CAS: 131043-22-6
• 化学式: C₁₂H₁₀F₄O₇
• 分子量: 342.201
• InChiKey: MSKSMLNPILLHIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  四氟乙烯 、 Trisodium;benzene-1,3,5-triolate 、 硫酸二甲酯 、 二氧化碳 生成 2,6-Dihydroxy-4-(1,1,2,2-tetrafluoro-2-methoxycarbonyl-ethoxy)-benzoic acid methyl ester
  参考文献：
  名称：

  ARNOLD-STANTON, REGINA;LEMAL, DAVID M., J. ORG. CHEM., 56,(1991) N, C. 151-157

  摘要：

  DOI：

文献信息

• Tandem nucleophilic additions of aryloxides
  作者：Regina Arnold-Stanton、David M. Lemal

  DOI：10.1021/jo00001a031

  日期：1991.1

  Hydroquinone disodium salt added sequentially to tetrafluoroethylene and carbon dioxide to yield a symmetrical dicarboxylic acid, which was transformed into the corresponding dimethyl ester, diol, diamide, and diamine. Chlorotrifluoroethylene in analogous reactions gave the corresponding diester and diol in excellent yield. When this kind of transformation was attempted on phloroglucinol, the Kolbe-Schmitt carboxylation reaction intervened. Despite serious competition from addition/elimination processes under typical reaction conditions, the tandem addition of phenoxide ion to hexafluoropropene and carbon dioxide was carried out successfully at lower temperatures and higher carbon dioxide pressures.