3-hydroxyhex-5-enoic acid | 120676-00-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 3-hydroxyhex-5-enoic acid
• 英文别名: 3-Hydroxy-5-hexenoic acid
• CAS: 120676-00-8
• 化学式: C₆H₁₀O₃
• mdl: MFCD19229647
• 分子量: 130.144
• InChiKey: XGWGWKJFMLNRSQ-UHFFFAOYSA-N

物化性质

• 沸点：
  280.2±28.0 °C(Predicted)
• 密度：
  1.129±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-hydroxyhex-5-enoic acid 在 碘 作用下， 以 乙腈 为溶剂， 反应 3.0h， 生成 4-Hydroxy-6-iodomethyl-tetrahydro-pyran-2-one
  参考文献：
  名称：

  酰基辅酶A：胆固醇O-酰基转移酶（ACAT）抑制剂。1. 2-（烷硫基）-4,5-二苯基-1H-咪唑类作为ACAT的有效抑制剂。

  摘要：

  生物有效的有效ACAT抑制剂可通过（i）减少饮食中胆固醇的吸收，（ii）减少极低密度脂蛋白从肝脏向血浆的分泌以及（iii）防止转化而对动脉粥样硬化产生有益作用巨噬细胞进入泡沫细胞。我们已经发现，含有4,5-二苯基-1H-咪唑-2-基部分的甲羟戊酸酯衍生物2在体外抑制大鼠肝微粒体ACAT，并在胆固醇喂养的大鼠中产生明显的降胆固醇作用。2的类似物的结构活性关系表明，4,5-二苯基-1H-咪唑部分是抑制大鼠微粒体ACAT的药效基团。

  DOI：

  10.1021/jm00101a016

文献信息

• PREPARATION METHOD FOR (R)-3-HYDROXYL-5-HEXENOATE
  申请人：FUDAN UNIVERSITY

  公开号：US20180340196A1

  公开（公告）日：2018-11-29

  The present disclosure relates to the technical field of biochemical engineering and particularly discloses a preparation method for (R)-3-hydroxyl-5-hexenoate. In the method of the present disclosure, the (R)-3-hydroxyl-5-hexenoate is prepared by catalytic reduction of 3-carbonyl-5-hexenoate by ketoreductase with 3-carbonyl-5-hexenoate as the substrate. The amino acid sequence of ketoreductase is shown in SEQ ID NO.1. In the present disclosure, the (R)-3-hydroxyl-5-hexenoate having a very high chiral purity is obtained by asymmetric reduction by ketoreductase as the biocatalyst. The present disclosure has the advantages of easy operation, mild reaction conditions, high reaction yield and good practical industrial application value.

  本公开涉及生物化学工程技术领域，特别涉及一种(R)-3-羟基-5-己烯酸的制备方法。在本公开的方法中，通过以3-羰基-5-己烯酸为底物，利用酮还酶催化还原3-羰基-5-己烯酸来制备(R)-3-羟基-5-己烯酸。酮还酶的氨基酸序列如SEQ ID NO.1所示。本公开通过以酮还酶为生物催化剂进行不对称还原，获得了具有非常高手性纯度的(R)-3-羟基-5-己烯酸。本公开具有操作简单、反应条件温和、反应产率高和实际工业应用价值好等优点。
• Multi-Arm Polymeric Alkanoate Conjugates
  申请人：Kozlowski Antoni

  公开号：US20110200550A1

  公开（公告）日：2011-08-18

  Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.

  本文提供了多臂聚合物共轭物，包括一种醇酸酯连接剂，以及包含这种共轭物的配方和相关的制备和给药方法。还提供了使用这种共轭物进行治疗的方法和相关用途。这些共轭物具有高药物负载效率。
• Granular fertilizer with a decomposable coating and process for producing the same
  申请人：Chisso Corporation

  公开号：EP0255752A2

  公开（公告）日：1988-02-10

  A granular fertilizer with a coating which is decomposable by soil microorganisms, preferably a coating which is decomposed and degraded both on the surface layer of the soil and in the soil, and a process for producing the granular fertilizer , which coating contains a poly 3-hydroxy-3-alkylpropionic acid as an indispensable ingredient, and if necessary, a resin or a low-molecular resin and further, if necessary, an inorganic or organic powder, and which process comprises adding an organic solvent solution of the poly 3-hydroxy-3-alkylpropionic acid, and if necessary, the resin, and if necessary the powder (dispersed in the solution) to a granular fertilizer in fluided state in the form of spray, and when added, blowing a high speed hot air stream onto the fertilizer to thereby instantaneously remove the solvent and also dry the resulting fertilizer.

  一种具有可被土壤微生物分解的涂层的颗粒肥料，最好是一种在土壤表层和土壤中均可被分解和降解的涂层，以及一种生产该颗粒肥料的工艺，该涂层含有一种聚3-羟基-3-烷基丙酸作为不可缺少的成分，必要时还含有一种树脂或低分子树脂，必要时还含有一种无机或有机粉末，该工艺包括加入聚3-羟基-3-烷基丙酸的有机溶剂溶液，必要时加入树脂，必要时加入粉末（分散在土壤中）、无机或有机粉末，该工艺包括将聚 3-羟基-3-烷基丙酸的有机溶剂溶液，必要时树脂，必要时粉末（分散在溶液中），以喷雾形式加入到流化状态的粒状肥料中，加入后，向肥料吹入高速热气流，从而瞬间除去溶剂，同时干燥得到的肥料。
• Production method of polyester containing epoxy group in side chain and production method of crosslinked polymer
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP1188836A2

  公开（公告）日：2002-03-20

  A method is provided which biosynthesizes a PHA having an epoxy group in a side chain terminal with improved physicochemical properties. Specifically, a method of producing a polyester containing an epoxy group in a side chain thereof using 1-alkene as a raw material is provided which comprises the steps of bringing 1-alkene into contact with a microorganism having an ability to uptake 1-alkene and convert it to a polyester and allowing the microorganism to convert the 1-alkene into a polyester containing an epoxy group in a side chain thereof. Further, a method of producing a crosslinked polymer is provided which comprises reacting the polyester obtained by the above mentioned method with a diamine compound.

  本发明提供了一种生物合成 PHA 的方法，该 PHA 的侧链末端含有环氧基团，具有更好的物理化学特性。具体地说，提供了一种以 1-烯为原料生产侧链中含有环氧基的聚酯的方法，该方法包括以下步骤：将 1-烯与具有吸收 1-烯并将其转化为聚酯能力的微生物接触，并使微生物将 1-烯转化为侧链中含有环氧基的聚酯。此外，还提供了一种生产交联聚合物的方法，该方法包括将通过上述方法获得的聚酯与二胺化合物反应。
• METHOD FOR PREPARING POLYLACTATE AND COPOLYMER THEREOF USING A MUTANT MICROORGANISM WITH ENHANCED POLYLACTATE, AND THE COPOLYMER PRODUCING CAPABILITY THEREOF
  申请人：LG Chem, Ltd.

  公开号：EP2314638A2

  公开（公告）日：2011-04-27

  Provided is a method of preparing polylactate (PLA) or a copolymer thereof using a mutant microorganism in which a gene participating in a coenzyme A (CoA) donor- and lactate-producing pathway is genetically manipulated to increase the productivity of a CoA donor and lactate. Amounts of the CoA donor and the lactate are simultaneously increased in a microbial metabolic pathway to enable effective biosynthesis of PLA and a hydroxyalkanoate-lactate copolymer having a high content of lactate, which is industrially useful.

  本发明提供了一种利用突变微生物制备聚乳酸（PLA）或其共聚物的方法，在这种突变微生物中，参与辅酶A（CoA）供体和乳酸盐产生途径的基因受到遗传操作，以提高CoA供体和乳酸盐的产量。在微生物代谢途径中，CoA 供体和乳酸盐的数量同时增加，从而能够有效地生物合成聚乳酸和具有高乳酸盐含量的羟基烷酸-乳酸盐共聚物，这在工业上是有用的。