4-[2-(乙硫基)乙氧基]苯胺 | 790617-44-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 4-[2-(乙硫基)乙氧基]苯胺
• 英文名称: 4-[2-(Ethylsulfanyl)ethoxy]aniline
• 英文别名: 4-(2-ethylsulfanylethoxy)aniline
• CAS: 790617-44-6
• 化学式: C₁₀H₁₅NOS
• 分子量: 197.3
• InChiKey: IOVZRGZIYDNDPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  60.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-(2-bromoethoxy)phenylamine 、 乙硫醇 生成 4-[2-(乙硫基)乙氧基]苯胺
  参考文献：
  名称：

  LYSENKO, V. P.;KARABANOV, YU. V.;PETRENKO, V. S.;GOLOLOBOV, YU. G.;BORISE+

  摘要：

  DOI：

文献信息

• HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS
  申请人：An Haoyun

  公开号：US20090048271A1

  公开（公告）日：2009-02-19

  Novel compounds having a fused bicyclic heteroaromatic ring system substituted with a heteroaryl five-membered ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo, and to reduce the size of tumors in vivo. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.

  本发明揭示了具有融合的双环杂芳环系统，其中含有一个杂环五元环的杂环取代的新化合物。这些化合物可以抑制多种类型的癌细胞的生长，因此可用于治疗癌症。这些化合物的疗效是通过一种监测细胞生长/迁移的系统来证明的，该系统显示它们是癌细胞生长和/或迁移的有效抑制剂。此外，本发明的化合物已被证明能够停止体内肿瘤的生长，并减小体内肿瘤的大小。本发明还揭示了包含这些化合物的组合物以及使用这些化合物和组合物治疗癌症的方法。
• LYSENKO, V. P.;KARABANOV, YU. V.;PETRENKO, V. S.;GOLOLOBOV, YU. G.;BORISE+
  作者：LYSENKO, V. P.、KARABANOV, YU. V.、PETRENKO, V. S.、GOLOLOBOV, YU. G.、BORISE+

  DOI：——

  日期：——
• US8252822B2
  申请人：——

  公开号：US8252822B2

  公开（公告）日：2012-08-28
• [EN] HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES ET UTILISATIONS COMME AGENTS ANTICANCÉREUX
  申请人：ACEA BIOSCIENCES INC

  公开号：WO2009023402A2

  公开（公告）日：2009-02-19

  Novel compounds having a fused bicyclic hetero aromatic ring system substituted with a heteroaryl five-membered ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo, and to reduce the size of tumors in vivo. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.