2-(5-methyl-3-phenyl-4-isoxazolyl)-indole | 80565-57-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(5-methyl-3-phenyl-4-isoxazolyl)-indole
• 英文别名: 2-(5-Methyl-3-phenyl-1,2-oxazol-4-yl)-1H-indole；4-(1H-indol-2-yl)-5-methyl-3-phenyl-1,2-oxazole
• CAS: 80565-57-7
• 化学式: C₁₈H₁₄N₂O
• 分子量: 274.322
• InChiKey: FFABMLBQMXLELN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  41.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(5-methyl-3-phenyl-4-isoxazolyl)-indole 、 草酰氯 生成 2-[2-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-1H-indol-3-yl]-2-oxoacetyl chloride
  参考文献：
  名称：

  BRAND, L. J.;NADELSON, J.

  摘要：

  DOI：
• 作为产物：
  描述：

  N-[(E)-1-(5-methyl-3-phenyl-1,2-oxazol-4-yl)ethylideneamino]aniline 生成 2-(5-methyl-3-phenyl-4-isoxazolyl)-indole
  参考文献：
  名称：

  BRAND, L. J.;NADELSON, J.

  摘要：

  DOI：

文献信息

• Isoxazolyl indolamines
  申请人：Sandoz, Inc.

  公开号：US04336378A1

  公开（公告）日：1982-06-22

  This disclosure describes compounds of the formula ##STR1## wherein R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms, or lower alkoxy having 1 to 4 carbon atoms, and R.sub.2 represents lower alkyl or ##STR2## where R.sub.5 represents hydrogen, fluoro, chloro, lower alkyl or lower alkoxy, and R.sub.3 and R.sub.4 each independently represent lower alkyl as defined above, and R.sub.3 and R.sub.4 together with N represent ##STR3## or pharmaceutically acceptable acid addition salts thereof, which are useful as anti-diabetic agents.

  本公开涉及以下式的化合物##STR1##其中R.sub.1代表氢、氟、氯、具有1到4个碳原子的低烷基，或具有1到4个碳原子的低烷氧基，而R.sub.2代表低烷基或##STR2##其中R.sub.5代表氢、氟、氯、低烷基或低烷氧基，而R.sub.3和R.sub.4各自独立地代表上述定义的低烷基，且R.sub.3和R.sub.4与N一起代表##STR3##或其药学上可接受的酸盐，这些化合物可用作抗糖尿病药物。
• Isoxazolyl indolamines for treating diabetes
  申请人：Sandoz, Inc.

  公开号：US04415568A1

  公开（公告）日：1983-11-15

  This disclosure describes compounds of the formula ##STR1## wherein R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms, or lower alkoxy having 1 to 4 carbon atoms, and R.sub.2 represents lower alkyl or ##STR2## where R.sub.5 represents hydrogen, fluoro, chloro, lower alkyl or lower alkoxy, and R.sub.3 and R.sub.4 each independently represent lower alkyl as defined above, and R.sub.3 and R.sub.4 together with N represent ##STR3## or pharmaceutically acceptable acid addition salts thereof, which are useful as anti-diabetic agents.

  本公开说明了以下式子的化合物：##STR1## 其中R.sub.1代表氢、氟、氯、1到4个碳原子的低碳基或1到4个碳原子的低碳氧基，R.sub.2代表低碳基或##STR2## 其中R.sub.5代表氢、氟、氯、低碳基或低碳氧基，R.sub.3和R.sub.4各自独立地代表如上定义的低碳基，而R.sub.3和R.sub.4与N一起代表##STR3## 或其药学上可接受的酸加盐，其作为抗糖尿病药物具有用途。
• Isoxazolyl indolamines as intermediates
  申请人：Sandoz, Inc.

  公开号：US04453001A1

  公开（公告）日：1984-06-05

  This disclosure describes compounds of the formula ##STR1## wherein R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms, or lower alkoxy having 1 to 4 carbon atoms, and R.sub.2 represents lower alkyl or ##STR2## where R.sub.5 represents hydrogen, fluoro, chloro, lower alkyl or lower alkoxy, and R.sub.3 and R.sub.4 each independently represent lower alkyl as defined above, and R.sub.3 and R.sub.4 together with N represent ##STR3## or pharmaceutically acceptable acid addition salts thereof, which are useful as anti-diabetic agents.

  本公开说明了化合物的公式 ##STR1## 其中R.sub.1代表氢，氟，氯，1至4个碳原子的低烷基或1至4个碳原子的低烷氧基，R.sub.2代表低烷基或 ##STR2## 其中R.sub.5代表氢，氟，氯，低烷基或低烷氧基，R.sub.3和R.sub.4各自独立地代表上述定义的低烷基，而R.sub.3和R.sub.4与N一起代表 ##STR3## 或其药学上可接受的酸加盐，其用作抗糖尿病剂。
• Isoxazolyl indolamines having anti-diabetic activity
  申请人：Sandoz, Inc.

  公开号：US04536499A1

  公开（公告）日：1985-08-20

  This disclosure describes novel compounds of the formula ##STR1## where m is 2, 3 or 4 X is hydrogen or hydroxy R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, and R.sub.2 and R.sub.3 each independently represent lower alkyl as defined above, or R.sub.2 and R.sub.3 together with N represent ##STR2## wherein n is 1, 2 or 3, and R.sub.4 represents hydrogen or lower alkyl as defined above, and R.sub.5 represents hydrogen, lower alkyl, phenyl or phenyl substituted with fluoro, chloro, lower alkyl having 1 to 4 carbon atoms, or lower alkoxy having 1 to 4 carbon atoms, with the proviso that when X is hydroxy, m is 3 or 4, or a pharmaceutically acceptable acid addition salt thereof, which are useful in the treatment of diabetes by inhibiting or impeding post-prandial hyperglycemia.

  本公开说明了一种新型化合物的公式，其中m为2、3或4，X为氢或羟基，R.sub.1代表氢、氟、氯、具有1至4个碳原子的较低烷基或具有1至4个碳原子的较低烷氧基，R.sub.2和R.sub.3各自独立地代表如上所定义的较低烷基，或者R.sub.2和R.sub.3与N一起代表##STR2##其中n为1、2或3，R.sub.4代表氢或如上所定义的较低烷基，R.sub.5代表氢、较低烷基、苯或用氟、氯、具有1至4个碳原子的较低烷基或具有1至4个碳原子的较低烷氧基取代的苯，但是当X为羟基时，m为3或4，或其药学上可接受的酸盐，用于通过抑制或阻碍餐后高血糖症治疗糖尿病。
• BRAND, L. J.;NADELSON, J.
  作者：BRAND, L. J.、NADELSON, J.

  DOI：——

  日期：——