S-(-)-2-n-propylsuccinic acid | 688-05-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: S-(-)-2-n-propylsuccinic acid
• 英文别名: (S)-2-propylsuccinic acid；S-(-)-α-Propylbernsteinsaeure；(S)-propyl-succinic acid；(S)-Propyl-bernsteinsaeure；(2S)-2-propylbutanedioic acid
• CAS: 688-05-1
• 化学式: C₇H₁₂O₄
• 分子量: 160.17
• InChiKey: QLTZBYGZXPKHLF-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  S-(-)-2-n-propylsuccinic acid 在 ammonium hydroxide 作用下， 以 乙醇 为溶剂， 以6.5 g的产率得到S-(+)-2-n-propylsuccinimide
  参考文献：
  名称：

  Bettoni, Giancarlo; Cellucci, Carla; Berardi, Francesco, Journal of Heterocyclic Chemistry, 1980, vol. 17, p. 603 - 605

  摘要：

  DOI：
• 作为产物：
  描述：

  丙琥珀酸 生成 S-(-)-2-n-propylsuccinic acid
  参考文献：
  名称：

  BETTONI G.; CELLUCCI C.; BERARDI F., J. HETEROCYCL. CHEM., 1980, 17, NO 3, 603-605

  摘要：

  DOI：

文献信息

• Retroviral protease inhibiting compounds
  申请人：ABBOTT LABORATORIES

  公开号：EP0402646A1

  公开（公告）日：1990-12-19

  A retroviral protease inhibiting compound of the formula or a pharmaceutical acceptable salt, prodrug or ester thereof, wherein X is a linking group; A is (1) substituted amino, (2) substituted carbonyl, (3) functionalized imino, (4) functionalized alkyl, (5) functionalized acyl, (6) functionalized heterocyclic or (7) functionalized (heterocyclic)alkyl; and B is (1) substituted carbonyl independently defined as herein, (2) substituted amino independently defined as herein, (3) functionalized imino independently defined as herein, (4) functionalized alkyl independently defined as herein, (5) functionalized acyl independently defined as herein, (6) functionalized heterocyclic independently defined as herein or (7) functionalized (heterocyclic)alkyl independently defined as herein.

  式中的逆转录病毒蛋白酶抑制化合物 或其药物可接受的盐、原药或酯，其中 X 是连接基团； A 是 (1) 取代的氨基 (2) 取代的羰基 (3) 官能化亚氨基 (4) 官能化烷基 (5) 官能化酰基 (6) 官能化杂环或 (7) 官能化（杂环）烷基；且 B 是 (1) 如本文所独立定义的取代的羰基、 (2) 如本文所独立定义的取代氨基 (3) 如本文所独立定义的官能化亚氨基 (4) 如本文所独立定义的官能化烷基、 (5) 如本文所独立定义的官能化酰基、 (6) 如本文所独立定义的官能化杂环，或 (7) 本文独立定义的官能化（杂环）烷基。
• Intermediates for preparating non-peptide retroviral protease inhibitors
  申请人：ABBOTT LABORATORIES

  公开号：EP0839798A2

  公开（公告）日：1998-05-06

  Intermediates, for preparing non-peptide retroviral protease inhibitors, said intermediates having the formula: or an acid addition salt thereof or an N-protected derivative thereof wherein at each occurrence the N-protecting group is independently selected from the group consisting of formyl, acetyl, pivaloyl, t-butylacetyl, t-butyloxycarbonyl, benzyloxycarbonyl, benzyl and isopropylaminocarbonyl; or said intermediates being selected from: (2S,3R,4S,5S)-2,5-di-(N-(Cbz-valinyl)amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S,3S,4S,5S)-2,5-di-(N-(Cbz-valinyl)amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S,3R,4R,5S)-2,5-di-(N-(Cbz-valinyl)amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S,3S,4S,5S)-2,5-di-(N-(valinyl)amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S,3R,4S,5S)-2,5-di-(N-(valinyl)amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S,3R,4R,5S)-2,5-di-(N-(valinyl)amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S,3S,4R,5S)-2-(N-(t-butyloxy)carbonyl)amino)-5-(N-(Cbz-valinyl)amino)-3,4-dihydroxy-1,6-diphenylhexane; 2-(N-benzyl-N-(benzyloxycarbonyl)amino)-5-(t-butyloxycarbonylamino)-1,6-diphenyl-3-hexene-3,4-oxide; 2-amino-5-(t-butyloxycarbonylamino)-1,6-diphenyl-3-hexene-3,4-oxide; and 2,5-di-(t-butyloxycarbonylamino)-1,6-diphenyl-3-hexene-3,4-oxide; or an acid addition salt thereof.

  用于制备非肽类逆转录病毒蛋白酶抑制剂的中间体，所述中间体具有以下式子： 或其酸加成盐或其 N-保护衍生物，其中每次出现时，N-保护基独立选自甲酰、乙酰、特戊酰、叔丁基乙酰、叔丁氧羰基、苄氧羰基、苄基和异丙氨基羰基组成的组；或所述中间体选自以下物质 (2S,3R,4S,5S)-2,5-二(N-(Cbz-缬氨酰)氨基)-3,4-二羟基-1,6-二苯基己烷； (2S,3S,4S,5S)-2,5-二(N-苄氧羰基缬氨酰氨基)-3,4-二羟基-1,6-二苯基己烷； (2S,3R,4R,5S)-2,5-二(N-苄氧羰基缬氨酰氨基)-3,4-二羟基-1,6-二苯基己烷； (2S,3S,4S,5S)-2,5-二(N-(缬氨酰)氨基)-3,4-二羟基-1,6-二苯基己烷； (2S,3R,4S,5S)-2,5-二(N-(缬氨酰)氨基)-3,4-二羟基-1,6-二苯基己烷； (2S,3R,4R,5S)-2,5-二(N-(缬氨酰)氨基)-3,4-二羟基-1,6-二苯基己烷； (2S,3S,4R,5S)-2-(N-(叔丁氧基)羰基)氨基)-5-(N-(Cbz-缬氨酰)氨基)-3,4-二羟基-1,6-二苯基己烷； 2-(N-苄基-N-(苄氧羰基)氨基)-5-(叔丁氧羰基氨基)-1,6-二苯基-3-己烯-3,4-氧化物； 2-氨基-5-(叔丁氧羰基氨基)-1,6-二苯基-3-己烯-3,4-氧化物；以及 2,5-二（叔丁氧羰基氨基）-1,6-二苯基-3-己烯-3,4-氧化物； 或其酸加成盐。
• Chemoenzymatic Synthesis of Glutamic Acid Analogues:  Substrate Specificity and Synthetic Applications of Branched Chain Aminotransferase from <i>Escherichia coli</i>
  作者：Mo Xian、Sébastien Alaux、Emmanuelle Sagot、Thierry Gefflaut

  DOI：10.1021/jo070805q

  日期：2007.9.1

  [GRAPHICS]A new route to alpha-keto acids is described, based on the ozonolysis of enol acetates obtained from alpha-substituted beta-keto esters. Escherichia coli branched chain aminotransferase (BCAT) activity toward a variety of substituted 2-oxoglutaric acids was demonstrated analytically. BCAT was shown to have a broad substrate spectrum, complementary to that of aspartate aminotransferase, and to offer access to a variety of glutamic acid analogues. The usefulness of BCAT was demonstrated through the synthesis of several 3- and 4-substituted derivatives.
• Bettoni, Giancarlo; Cellucci, Carla; Berardi, Francesco, Journal of Heterocyclic Chemistry, 1980, vol. 17, p. 603 - 605
  作者：Bettoni, Giancarlo、Cellucci, Carla、Berardi, Francesco

  DOI：——

  日期：——
• Prostaglandin analogues, processes for their preparation and pharmaceutical compositions containing them
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP0196380B1

  公开（公告）日：1991-09-18