3-morpholinobutan-2-one | 6050-57-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 3-morpholinobutan-2-one
• 英文别名: 3-Morpholino-butanon-(2)；3-morpholin-4-yl-butan-2-one；3-morpholinylbutan-2-one；3-Morpholin-4-ylbutan-2-one
• CAS: 6050-57-3
• 化学式: C₈H₁₅NO₂
• mdl: MFCD12146899
• 分子量: 157.213
• InChiKey: OFRJPOFIMSGUJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-morpholinobutan-2-one 在 钾硼氢 、 sodium carbonate 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成 (E)-1-Benzo[1,3]dioxol-5-yl-4-morpholin-4-yl-pent-1-en-3-ol
  参考文献：
  名称：

  Astoin; Lepage; Poisson, European Journal of Medicinal Chemistry, 1985, vol. 20, # 6, p. 495 - 500

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3-dimethyl-2-nitro-oxirane 、 吗啉 以39%的产率得到
  参考文献：
  名称：

  SOKOLOV N. A.; TISHCHENKO I. G.; KOVGANKO N. V., ZH. ORGAN. XIMII, 1978, 14, HO 3, 517-519

  摘要：

  DOI：

文献信息

• Methods for synthesis of acyloxyalkyl compounds
  申请人：Bhat Laxminarayan

  公开号：US20050070715A1

  公开（公告）日：2005-03-31

  Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in high yield, do not require the use of activated intermediates and/or toxic compounds and are readily amenable to scale-up.

  本文公开了一种通过在无水反应条件下氧化药物的1-酰基-烷基衍生物来合成药物的1-(酰氧基)-烷基前药衍生物的方法。该方法通常具有立体选择性，产率高，不需要使用活性中间体和/或有毒化合物，并且容易扩大规模。
• Dynamic kinetic asymmetric arylation and alkenylation of ketones
  作者：Lin-Xin Ruan、Bo Sun、Jia-Ming Liu、Shi-Liang Shi

  DOI：10.1126/science.ade0760

  日期：2023.2.17

  Despite the importance of enantioenriched alcohols in medicinal chemistry, total synthesis, and materials science, the efficient and selective construction of enantioenriched tertiary alcohols bearing two contiguous stereocenters has remained a substantial challenge. We report a platform for their preparation through the enantioconvergent, nickel-catalyzed addition of organoboronates to racemic, nonactivated

  尽管富含对映体的醇在药物化学、全合成和材料科学中具有重要意义，但有效和选择性地构建具有两个相邻立构中心的富含对映体的叔醇仍然是一个巨大的挑战。我们报告了一个通过对映收敛、镍催化的有机硼酸盐加成外消旋非活化酮来制备它们的平台。我们通过芳基和烯基亲核试剂的动态动力学不对称加成，一步制备了几类重要的 α,β-手性叔醇，具有高水平的非对映选择性和对映选择性。我们应用此协议来修改几种洛芬药物并快速合成生物学相关分子。我们期望这种镍催化的，
• Metal chemical mechanical planarization (CMP) composition and methods therefore
  申请人：Versum Materials US, LLC

  公开号：US10465096B2

  公开（公告）日：2019-11-05

  Provided are Chemical Mechanical Planarization (CMP) formulations that offer high and tunable Cu removal rates and low copper dishing for the broad or advanced node copper or Through Silica Via (TSV). The CMP compositions provide high selectivity of Cu film vs. other barrier layers, such as Ta, TaN, Ti, and TiN, and dielectric films, such as TEOS, low-k, and ultra low-k films. The CMP polishing formulations comprise water; abrasive; single chelator, dual chelators or tris chelators; morpholino family compounds as Cu dishing reducing agents. Additionally, organic quaternary ammonium salt, corrosion inhibitor, oxidizer, pH adjustor and biocide can be used in the formulations.

  所提供的化学机械平坦化（CMP）配方可为宽节点或先进节点铜或硅通孔（TSV）提供高且可调的铜去除率和低铜偏移。与其他阻挡层（如钽、钽镍、钛和钛镍）和介电薄膜（如 TEOS、低 K 和超低 K 薄膜）相比，CMP 组合物具有较高的铜膜选择性。CMP 抛光配方包括水；研磨剂；单螯合剂、双螯合剂或三螯合剂；作为铜排减剂的吗啉族化合物。此外，配方中还可使用有机季铵盐、缓蚀剂、氧化剂、pH 值调节剂和杀菌剂。
• Simple Catalytic Mechanism for the Direct Coupling of α-Carbonyls with Functionalized Amines: A One-Step Synthesis of Plavix
  作者：Ryan W. Evans、Jason R. Zbieg、Shaolin Zhu、Wei Li、David W. C. MacMillan

  DOI：10.1021/ja4096472

  日期：2013.10.30

  The direct alpha-amination of ketones, esters, and aldehydes has been accomplished via copper catalysis. In the presence of catalytic copper(II) bromide, a diverse range of carbonyl and amine substrates undergo fragment coupling to produce synthetically useful alpha-amino-substituted motifs. The transformation is proposed to proceed via a catalytically generated alpha-bromo carbonyl species; nucleophilic displacement of the bromide by the amine then delivers the alpha-amino carbonyl adduct while the catalyst is reconstituted. The practical value of this transformation is highlighted through one-step syntheses of two high-profile pharmaceutical agents, Plavix and amfepramone.
• IMIDAZOL DERIVATIVES AS RAF KINASE INHIBITORS
  申请人：SmithKline Beecham plc

  公开号：EP1263753A1

  公开（公告）日：2002-12-11