申请人:American Hoechst Corporation
公开号:US03997539A1
公开(公告)日:1976-12-14
New 3-(4-acylaminopiperazin-1-ylalkyl)indole compounds, and their immediate precursors possessing antihypertensive and tranquilizing properties, their physiologically acceptable salts and a process for the preparation thereof are described; said compounds are of the general formula: ##STR1## wherein X represents hydrogen or hydroxy, n can vary from 0-1, R.sub.1 and R.sub.2 each represents hydrogen or alkoxy of 1-2 carbon atoms; R.sub.3 represents hydrogen or alkyl of 1-3 carbon atoms and Z represents hydrogen or ##STR2## and R.sub.4 is selected from a member of the group consisting of alkyl of 1-4 carbon atoms, benzhydryl, cycloalkyl of 6-10 carbon atoms; bridged cycloalkyl of 6-10 carbon atoms, phenyl, mono, di or tri substituted phenyl, and heterocyclic moieties such as pyridyl, furyl, pyrrolyl, thienyl, pyrazinyl.
本文描述了一种新型3-(4-酰胺基哌嗪-1-基烷基)吲哚化合物及其即时前体,具有降压和镇静作用,其生理上可接受的盐和制备方法;所述化合物的一般公式为:##STR1## 其中X代表氢或羟基,n可在0-1之间变化,R.sub.1和R.sub.2分别代表1-2碳原子的氢或烷氧基;R.sub.3代表1-3碳原子的氢或烷基,Z代表氢或##STR2## 而R.sub.4选自以下成员组成的群:1-4碳原子的烷基,苯甲基,6-10碳原子的环烷基;6-10碳原子的桥接环烷基,苯基,单取代苯基、二取代苯基或三取代苯基,以及如吡啶基、呋喃基、吡咯基、噻吩基、吡嗪基等杂环基团。