(R)-2-(2-ethoxy-phenoxymethyl)-morpholine | 52730-45-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (R)-2-(2-ethoxy-phenoxymethyl)-morpholine
• 英文别名: (R)-Viloxazine；(2R)-2-[(2-ethoxyphenoxy)methyl]morpholine
• CAS: 52730-45-7
• 化学式: C₁₃H₁₉NO₃
• mdl: MFCD00865384
• 分子量: 237.299
• InChiKey: YWPHCCPCQOJSGZ-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  39.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (R)-2-(2-ethoxy-phenoxymethyl)-4-isopropyl-morpholine 生成 (R)-2-(2-ethoxy-phenoxymethyl)-morpholine
  参考文献：
  名称：

  Optical isomers of 2-(2-ethoxyphenoxymethyl)tetrahydro-1,4-oxazine (viloxazine) and related compounds

  摘要：

  The optical isomers of 2-(2-ethoxyphenoxymethyl)tetrahydro-1,4-oxazine (viloxazine) and 2-(3-methoxyphenoxymethyl)tetrahydro-1,4-oxazine have been prepared and absolute configurations have been assigned. In their action on the central nervous system the S isomers are at least ten times more potent than the R isomers. The intermediate 4-benzyl-2-(p-toluensulfonyloxymethyl)tetrahydro-1,4-oxazine has been resolved. Its isomers provide a convenient starting point for the preparation of optical isomers of viloxazine analogues of known configuration.

  DOI：

  10.1021/jm00230a021

文献信息

• METHODS FOR PRODUCING VILOXAZINE SALTS AND NOVEL POLYMORPHS THEREOF
  申请人：Liang Likan

  公开号：US20110251198A1

  公开（公告）日：2011-10-13

  Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HCl while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.

  这里提供了制备维洛西嗪及其各种盐的方法，以及维洛西嗪相关化合物，如新型中间反应产物和其多晶形式。具体而言，这些方法提供了维洛西嗪盐酸盐的基本纯净API，同时避免了不良杂质。这些方法进一步提供了分离、鉴定和表征维洛西嗪新型多晶形式的方法。此外，还提供了维洛西嗪新中间体的合成、鉴定和表征方法，以及一些重要代谢产物和代谢产物前体的合成方法。
• Methods for producing viloxazine salts and novel polymorphs thereof
  申请人：Supernus Pharmaceuticals, Inc.

  公开号：US10005743B2

  公开（公告）日：2018-06-26

  Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HCl while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.

  这里提供的是维洛沙嗪及其各种盐类以及维洛沙嗪相关化合物（如新型中间反应产物及其多晶型）的制造方法。特别是，这些方法提供了基本纯净的盐酸维洛沙嗪原料药，同时避免了不需要的杂质。这些方法还提供了分离、鉴定和表征新型多晶型维洛沙嗪的方法。此外，还提供了合成、鉴定和表征维洛沙嗪新型中间体以及维洛沙嗪的一些重要代谢物和代谢物前体的方法。
• HOWE R.; LEIGH T.; RAO B. S.; TODD A. H., J. MED. CHEM. <JMCM-AR>, 1976, 19, NO 8, 1074-1076
  作者：HOWE R.、 LEIGH T.、 RAO B. S.、 TODD A. H.

  DOI：——

  日期：——
• DERIVATIVES OF SUBSTITUTED MORPHOLINES AND USES THEREOF
  申请人：Supernus Pharmaceuticals, Inc.

  公开号：US20220306618A1

  公开（公告）日：2022-09-29

  A compound of Formula I includes a stereoisomer thereof and/or a salt thereof; wherein R 1 is a substituted alkane group, a heterocylic group, or a pyridine group; X is hydrogen, a halogen, an amino acid residue, a substituted amino acid residue, an alkyl group, or an ester. Such compounds may be used in pharmaceutical compositions and for the treatment of central nervous system (CNS) disorders:
• US4124709A
  申请人：——

  公开号：US4124709A

  公开（公告）日：1978-11-07