1-Methoxy-4-((Z)-(R)-2-methoxymethoxy-hept-4-enyloxymethyl)-benzene | 155626-55-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Methoxy-4-((Z)-(R)-2-methoxymethoxy-hept-4-enyloxymethyl)-benzene
• 英文别名: 1-methoxy-4-[[(Z,2R)-2-(methoxymethoxy)hept-4-enoxy]methyl]benzene
• CAS: 155626-55-4
• 化学式: C₁₇H₂₆O₄
• 分子量: 294.391
• InChiKey: HZXIRWOWNKIQDU-KEGWNNHHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-Methoxy-4-((Z)-(R)-2-methoxymethoxy-hept-4-enyloxymethyl)-benzene 在 草酰氯 、 二甲基亚砜 、 三乙胺 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 0.5h， 生成 (Z)-(R)-2-Methoxymethoxy-hept-4-enal
  参考文献：
  名称：

  Synthesis of (Z)-homoallylic alcohols and homoprop-2-ynylic alcohols via palladium-catalysed hydrogenolysis of prop-2-ynylic cyclic carbonates

  摘要：

  The decarboxylation-hydrogenolysis of prop-2-ynylic cyclic carbonates which have an internal acetylenic bond with ammonium formate in the presence of a catalytic amount of [Pd(acac)(2)l and Bu(3)(n)P afforded (Z)-homoallylic alcohols or homoprop-2-ynylic alcohols depending on the reaction conditions, however, hydrogenolysis of terminal prop-2-ynylic cyclic carbonates gave homoallylic alcohols; using (Z)-homoallylic alcohol 2b ass chiral synthon, the male sex pheromone of the pyralid moth Aphomia gularis has been synthesized.

  DOI：

  10.1039/p19940000237
• 作为产物：
  描述：

  (R)-1-(4-Methoxy-benzyloxy)-hept-4-yn-2-ol 在 bis(acetylacetonato)palladium(II) 三丁基膦 、 甲酸铵 、 N,N-二异丙基乙胺 作用下， 以 苯 为溶剂， 反应 5.0h， 生成 1-Methoxy-4-((Z)-(R)-2-methoxymethoxy-hept-4-enyloxymethyl)-benzene
  参考文献：
  名称：

  Synthesis of (Z)-homoallylic alcohols and homoprop-2-ynylic alcohols via palladium-catalysed hydrogenolysis of prop-2-ynylic cyclic carbonates

  摘要：

  The decarboxylation-hydrogenolysis of prop-2-ynylic cyclic carbonates which have an internal acetylenic bond with ammonium formate in the presence of a catalytic amount of [Pd(acac)(2)l and Bu(3)(n)P afforded (Z)-homoallylic alcohols or homoprop-2-ynylic alcohols depending on the reaction conditions, however, hydrogenolysis of terminal prop-2-ynylic cyclic carbonates gave homoallylic alcohols; using (Z)-homoallylic alcohol 2b ass chiral synthon, the male sex pheromone of the pyralid moth Aphomia gularis has been synthesized.

  DOI：

  10.1039/p19940000237

文献信息

• Synthesis of (Z)-homoallylic alcohols and homoprop-2-ynylic alcohols via palladium-catalysed hydrogenolysis of prop-2-ynylic cyclic carbonates
  作者：Suk-Ku Kang、Dong-Chul Park、Dong-Gyu Cho、Jea-Uk Chung、Kyung-Yun Jung

  DOI：10.1039/p19940000237

  日期：——

  The decarboxylation-hydrogenolysis of prop-2-ynylic cyclic carbonates which have an internal acetylenic bond with ammonium formate in the presence of a catalytic amount of [Pd(acac)(2)l and Bu(3)(n)P afforded (Z)-homoallylic alcohols or homoprop-2-ynylic alcohols depending on the reaction conditions, however, hydrogenolysis of terminal prop-2-ynylic cyclic carbonates gave homoallylic alcohols; using (Z)-homoallylic alcohol 2b ass chiral synthon, the male sex pheromone of the pyralid moth Aphomia gularis has been synthesized.