4-ethoxy-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-ol | 649736-25-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并三嗪类
• 英文名称: 4-ethoxy-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-ol
• 英文别名: Pyrrolo[2,1-f][1,2,4]triazin-6-ol, 4-ethoxy-5-methyl-
• CAS: 649736-25-4
• 化学式: C₉H₁₁N₃O₂
• 分子量: 193.205
• InChiKey: NEAOGJFZYQUSRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  59.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-ethoxy-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-ol 、 溴甲苯 在 potassium carbonate 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 12.0h， 生成 6-benzyloxy-4-ethoxy-5-methylpyrrolo[2,1-f][1,2,4]triazine
  参考文献：
  名称：

  [EN] PROCESS FOR PREPARING CERTAIN PYRROLOTRIAZINE COMPOUNDS
  [FR] PROCEDE DE PREPARATION DE CERTAINS COMPOSES DE PYRROLOTRIAZINE

  摘要：

  公开号：

  WO2004009542A3
• 作为产物：
  描述：

  2-(4-ethoxy-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)-propan-2-ol 在 三氟化硼乙醚 、 双氧水 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以76%的产率得到4-ethoxy-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-ol
  参考文献：
  名称：

  [EN] PROCESS FOR PREPARING CERTAIN PYRROLOTRIAZINE COMPOUNDS
  [FR] PROCEDE DE PREPARATION DE CERTAINS COMPOSES DE PYRROLOTRIAZINE

  摘要：

  公开号：

  WO2004009542A3

文献信息

• Modified amino acids
  申请人：Technische Universität Wien

  公开号：EP1826199A1

  公开（公告）日：2007-08-29

  The present invention provides a compound of the general formula 1, wherein X is the connection between the CO-hydrazine and the NR1-oxalic acid or ester group, and uses and synthesis methods. These compounds represent amino acid derivatives, wherein the amine group is turned into an acidic group by the oxalic acid group and the carboxylic acid is turned into an amine functionality by the hydrazine group; as well as peptidomimetics comprising the compound and methods for their synthesis.

  本发明提供了一种一般式1的化合物， 其中X是CO-肼和NR1-草酸或酯基之间的连接，并提供了使用和合成方法。这些化合物代表氨基酸衍生物，其中氨基团通过草酸基转化为酸性基团，羧酸通过肼基转化为氨基功能团；以及包括该化合物的肽类似物和其合成方法。
• [EN] NOVEL INHIBITORS OF KINASES<br/>[FR] NOUVEAUX INHIBITEURS DE KINASES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2004009784A2

  公开（公告）日：2004-01-29

  The present invention provides compounds of formula (I), and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

  本发明提供了式（I）的化合物及其药学上可接受的盐。式（I）化合物抑制生长因子受体的酪氨酸激酶活性，如VEGFR-2和FGFR-1，因此使它们有用作抗癌剂。式（I）化合物还可用于治疗与通过生长因子受体进行信号转导途径相关的其他疾病。
• Novel inhibitors of kinases
  申请人：——

  公开号：US20040072832A1

  公开（公告）日：2004-04-15

  The present invention provides compounds of formula I, 1 and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

  本发明提供公式I的化合物及其药学上可接受的盐。公式I的化合物抑制生长因子受体的酪氨酸激酶活性，例如VEGFR-2和FGFR-1，因此使它们成为抗癌剂。公式I的化合物还可用于治疗与信号转导途径相关的其他疾病，这些途径通过生长因子受体运作。
• Process for preparing certain pyrrolotriazine compounds
  申请人：——

  公开号：US20040077858A1

  公开（公告）日：2004-04-22

  The present invention relates to a process for preparing certain pyrrolotriazine compounds of the formula 1 and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

  本发明涉及一种制备化合物式1及其药学上可接受的盐的吡咯并三嗪类化合物的方法。式I化合物抑制生长因子受体如VEGFR-2和FGFR-1的酪氨酸激酶活性，因此它们可作为抗癌剂使用。式I化合物还可用于治疗与通过生长因子受体进行信号转导途径相关的其他疾病。
• NOVEL INHIBITORS OF KINASES
  申请人：Bhide S. Rajeev

  公开号：US20070299075A1

  公开（公告）日：2007-12-27

  The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

  本发明提供了I式化合物及其药学上可接受的盐。I式化合物抑制生长因子受体如VEGFR-2和FGFR-1的酪氨酸激酶活性，因此可用作抗癌剂。I式化合物还可用于治疗通过生长因子受体操作的信号转导途径引起的其他疾病。